p53 is usually referred to as a commonly altered tumour suppressor gene. A new study supports a decade of accumulating evidence that mutated p53 protein can gain new functions and also behave as an oncogene. This study specifically suggests that certain p53 mutants gain the ability to inhibit the MRN–ATM signalling pathway.
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Kastan, M., Berkovich, E. p53: a two-faced cancer gene. Nat Cell Biol 9, 489–491 (2007). https://doi.org/10.1038/ncb0507-489
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DOI: https://doi.org/10.1038/ncb0507-489
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