Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.
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Clarke, P. Anchoring RCC1 by the tail. Nat Cell Biol 9, 485–487 (2007). https://doi.org/10.1038/ncb0507-485
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DOI: https://doi.org/10.1038/ncb0507-485
