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References
Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1006–1010.
Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1001–1005.
Wellcome Trust Case Control C. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661–678.
Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C et al. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst 2013; 105: 733–742.
Ward LD, Kellis M . HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 2012; 40: D930–D934.
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012; 22: 1790–1797.
Consortium GT . The Genotype-Tissue Expression (GTEx) project. Nat Genet 2013; 45: 580–585.
Pique-Regi R, Degner JF, Pai AA, Gaffney DJ, Gilad Y, Pritchard JK . Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data. Genome Res 2011; 21: 447–455.
Xiao J, Lee ST, Xiao Y, Ma X, Andres Houseman E, Hsu LI et al. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135: 1101–1109.
Yamanaka R, Barlow C, Lekstrom-Himes J, Castilla LH, Liu PP, Eckhaus M et al. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc Natl Acad Sci USA 1997; 94: 13187–13192.
Starnes LM, Sorrentino A . Regulatory circuitries coordinated by transcription factors and microRNAs at the cornerstone of hematopoietic stem cell self-renewal and differentiation. Curr Stem Cell Res Ther 2011; 6: 142–161.
Schwickert TA, Tagoh H, Gultekin S, Dakic A, Axelsson E, Minnich M et al. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol 2014; 15: 283–293.
Schmidt CA, Przybylski GK . What can we learn from leukemia as for the process of lineage commitment in hematopoiesis? Int Rev Immunol 2001; 20: 107–115.
Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D et al. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet 2013; 45: 1494–1498.
Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL et al. Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Blood 2013; 122: 3298–3307.
Acknowledgements
This work was financially supported by NCI R01CA155461 (JLW, KMW), NCI R25CA112355 (KMW), NIEHS and EPA P01ES018172 (CM, JLW), NIEHS R01ES09137 (CM, JLW), and the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health P01DK088760 (MOM and MEF). A full list of acknowledgements can be found in the online supplement.
Author contributions
JLW and KMW designed experiments, analyzed the data, and wrote the manuscript. AJdS and JQ designed and performed experiments and helped write the manuscript. S-TL helped analyze the data. MOM and MEF supplied key reagents and helped perform experiments. MZ and HH performed experiments. AT and CM secured clinical and population samples. All authors read and finalized the manuscript.
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Wiemels, J., de Smith, A., Xiao, J. et al. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia 30, 1194–1197 (2016). https://doi.org/10.1038/leu.2015.251
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DOI: https://doi.org/10.1038/leu.2015.251
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