Genetics

Definition

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

Featured

Latest Research and Reviews

  • Research |

    Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

    • Nathan D. Grubaugh
    • , Jason T. Ladner
    • , Moritz U. G. Kraemer
    • , Gytis Dudas
    • , Amanda L. Tan
    • , Karthik Gangavarapu
    • , Michael R. Wiley
    • , Stephen White
    • , Julien Thézé
    • , Diogo M. Magnani
    • , Karla Prieto
    • , Daniel Reyes
    • , Andrea M. Bingham
    • , Lauren M. Paul
    • , Refugio Robles-Sikisaka
    • , Glenn Oliveira
    • , Darryl Pronty
    • , Carolyn M. Barcellona
    • , Hayden C. Metsky
    • , Mary Lynn Baniecki
    • , Kayla G. Barnes
    • , Bridget Chak
    • , Catherine A. Freije
    • , Adrianne Gladden-Young
    • , Andreas Gnirke
    • , Cynthia Luo
    • , Bronwyn MacInnis
    • , Christian B. Matranga
    • , Daniel J. Park
    • , James Qu
    • , Stephen F. Schaffner
    • , Christopher Tomkins-Tinch
    • , Kendra L. West
    • , Sarah M. Winnicki
    • , Shirlee Wohl
    • , Nathan L. Yozwiak
    • , Joshua Quick
    • , Joseph R. Fauver
    • , Kamran Khan
    • , Shannon E. Brent
    • , Robert C. Reiner Jr
    • , Paola N. Lichtenberger
    • , Michael J. Ricciardi
    • , Varian K. Bailey
    • , David I. Watkins
    • , Marshall R. Cone
    • , Edgar W. Kopp IV
    • , Kelly N. Hogan
    • , Andrew C. Cannons
    • , Reynald Jean
    • , Andrew J. Monaghan
    • , Robert F. Garry
    • , Nicholas J. Loman
    • , Nuno R. Faria
    • , Mario C. Porcelli
    • , Chalmers Vasquez
    • , Elyse R. Nagle
    • , Derek A. T. Cummings
    • , Danielle Stanek
    • , Andrew Rambaut
    • , Mariano Sanchez-Lockhart
    • , Pardis C. Sabeti
    • , Leah D. Gillis
    • , Scott F. Michael
    • , Trevor Bedford
    • , Oliver G. Pybus
    • , Sharon Isern
    • , Gustavo Palacios
    •  & Kristian G. Andersen
  • Research |

    One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.

    • Hayden C. Metsky
    • , Christian B. Matranga
    • , Shirlee Wohl
    • , Stephen F. Schaffner
    • , Catherine A. Freije
    • , Sarah M. Winnicki
    • , Kendra West
    • , James Qu
    • , Mary Lynn Baniecki
    • , Adrianne Gladden-Young
    • , Aaron E. Lin
    • , Christopher H. Tomkins-Tinch
    • , Simon H. Ye
    • , Daniel J. Park
    • , Cynthia Y. Luo
    • , Kayla G. Barnes
    • , Rickey R. Shah
    • , Bridget Chak
    • , Giselle Barbosa-Lima
    • , Edson Delatorre
    • , Yasmine R. Vieira
    • , Lauren M. Paul
    • , Amanda L. Tan
    • , Carolyn M. Barcellona
    • , Mario C. Porcelli
    • , Chalmers Vasquez
    • , Andrew C. Cannons
    • , Marshall R. Cone
    • , Kelly N. Hogan
    • , Edgar W. Kopp
    • , Joshua J. Anzinger
    • , Kimberly F. Garcia
    • , Leda A. Parham
    • , Rosa M. Gélvez Ramírez
    • , Maria C. Miranda Montoya
    • , Diana P. Rojas
    • , Catherine M. Brown
    • , Scott Hennigan
    • , Brandon Sabina
    • , Sarah Scotland
    • , Karthik Gangavarapu
    • , Nathan D. Grubaugh
    • , Glenn Oliveira
    • , Refugio Robles-Sikisaka
    • , Andrew Rambaut
    • , Lee Gehrke
    • , Sandra Smole
    • , M. Elizabeth Halloran
    • , Luis Villar
    • , Salim Mattar
    • , Ivette Lorenzana
    • , Jose Cerbino-Neto
    • , Clarissa Valim
    • , Wim Degrave
    • , Patricia T. Bozza
    • , Andreas Gnirke
    • , Kristian G. Andersen
    • , Sharon Isern
    • , Scott F. Michael
    • , Fernando A. Bozza
    • , Thiago M. L. Souza
    • , Irene Bosch
    • , Nathan L. Yozwiak
    • , Bronwyn L. MacInnis
    •  & Pardis C. Sabeti
  • Reviews |

    Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.

    • Michael Potente
    •  & Taija Mäkinen
  • Protocols |

    This multiplex PCR enrichment protocol enables sequencing of Zika and other viral genomes of low abundance from clinical samples using the Illumina platform, or the portable MinION sequencer, facilitating direct application in field situations.

    • Joshua Quick
    • , Nathan D Grubaugh
    • , Steven T Pullan
    • , Ingra M Claro
    • , Andrew D Smith
    • , Karthik Gangavarapu
    • , Glenn Oliveira
    • , Refugio Robles-Sikisaka
    • , Thomas F Rogers
    • , Nathan A Beutler
    • , Dennis R Burton
    • , Lia Laura Lewis-Ximenez
    • , Jaqueline Goes de Jesus
    • , Marta Giovanetti
    • , Sarah C Hill
    • , Allison Black
    • , Trevor Bedford
    • , Miles W Carroll
    • , Marcio Nunes
    • , Luiz Carlos Alcantara Jr.
    • , Ester C Sabino
    • , Sally A Baylis
    • , Nuno R Faria
    • , Matthew Loose
    • , Jared T Simpson
    • , Oliver G Pybus
    • , Kristian G Andersen
    •  & Nicholas J Loman
    Nature Protocols 12, 1261–1276

News and Comment