tn7: smarter than we thought. Peters, J. E. & Craig, N. L. Nature Reviews Molecular Cell Biology November (2001) A review on the bacterial transposon Tn7, which has developed several ways to promote its propagation in host genomes.

Islands of linkage disequilibrium. Goldstein, D. B. Nature Genetics October (2001) A News and Views article on new data indicating that linkage disequilibrium is highly structured into discrete blocks of sequence that are separated by hot spots of recombination.

Cancer gene therapy: fringe or cutting edge? McCormick, F. Nature Reviews Cancer November (2001)

Pharmacogenetics and cancer therapy. Relling, M. V. & Dervieux, T. Nature Reviews Cancer November (2001)

Knockout drug screens. Prendergast, G. C. Nature Biotechnology October (2001) A News and Views article on isogenic cell lines that differ by a single genetic change, which show promise in drug screens for identifying compounds with gene-selective properties.

Special focus on development. Nature Reviews Neuroscience November (2001) Articles in this issue include:

Cutting, pasting and painting: experimental embryology and neural development. Schoenwolf, G. C.

Neurons from stem cells: preventing an identity crisis. Svendsen, C. N., Bhattacharyya, A. & Tai, Y. T.

Markers in neurogenesis: lessons from the vertebrate embryo. Diez del Corral, R. & Storey, K.

To clot or not. Fosang, A. J. & Smith, P. J. Nature 4 October (2001). A News and Views article on the cloning of the gene that causes the human blood-clotting disorder, thrombotic thrombocytopenic purpura. The affected gene, ADAMTS13 , encodes a proteinase that is required for proper cleavage of the Von Willebrand clotting factor.