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| Open AccessTargeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
- Sarah Klinnert
- , Corinne D. Schenkel
- & Karin J. Metzner
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Article |
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep
- Amira D. Rghei
- , Laura P. van Lieshout
- & Sarah K. Wootton
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Perspective
| Open AccessInsidious Insights: Implications of viral vector engineering for pathogen enhancement
- Jonas B. Sandbrink
- , Ethan C. Alley
- & Kevin M. Esvelt
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Article
| Open AccessA short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity
- Winston Colon-Moran
- , Alan Baer
- & Nirjal Bhattarai
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Brief Communication
| Open AccessNovel tool to quantify with single-cell resolution the number of incoming AAV genomes co-expressed in the mouse nervous system
- Carola J. Maturana
- , Jessica L. Verpeut
- & Esteban A. Engel
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Review Article |
Intracellular trafficking of adeno-associated virus (AAV) vectors: challenges and future directions
- Jalish M. Riyad
- & Thomas Weber
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Brief Communication |
AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge
- Matthew M. Guilleman
- , Brenna A. Y. Stevens
- & Sarah K. Wootton
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Article |
Neutralisation of adeno-associated virus transduction by human vitreous humour
- Sławomir Andrzejewski
- , Peter M. Moyle
- & Christopher J. Layton
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Article |
Bat adeno-associated viruses as gene therapy vectors with the potential to evade human neutralizing antibodies
- Ya Li
- , Jialu Li
- & Lin Yang
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Article |
Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus
- Slawomir Andrzejewski
- , Aparna Murali
- & Christopher J. Layton
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Article |
Measles vector as a multigene delivery platform facilitating iPSC reprogramming
- Qi Wang
- , Alanna Vossen
- & Patricia Devaux
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Article |
Characterization of a replicating expanded tropism oncolytic reovirus carrying the adenovirus E4orf4 gene
- Vera Kemp
- , Iris J. C. Dautzenberg
- & Diana J. M. van den Wollenberg
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Original Article
| Open AccessTropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina
- D G Hickey
- , T L Edwards
- & R E MacLaren
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Original Article |
Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1α in a rat cystitis model induced by hydrogen peroxide
- S Takai
- , T Majima
- & N Yoshimura
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Original Article |
Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I
- L Bočkor
- , G Bortolussi
- & A F Muro
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Short Communication |
Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys
- G F Bischof
- , Y C Shin
- & R C Desrosiers
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Original Article |
Synergistic effects of deleting multiple nonessential elements in nonreplicative HSV-1 BAC genomic vectors play a critical role in their viability
- M Ventosa
- , A Ortiz-Temprano
- & F Lim
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Original Article |
Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle
- J P Gomez
- , C Gonçalves
- & P Midoux
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Original Article
| Open AccessCharacterization of retroviral infectivity and superinfection resistance during retrovirus-mediated transduction of mammalian cells
- J Liao
- , Q Wei
- & J Wang
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Original Article - Enabling Technologies |
Improved gene delivery to adult mouse spinal cord through the use of engineered hybrid adeno-associated viral serotypes
- J J Siu
- , N J Queen
- & L Cao
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Original Article |
T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates
- C S Rollier
- , E J Verschoor
- & J L Heeney
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Original Article
| Open AccessThe relevance of coagulation factor X protection of adenoviruses in human sera
- M R Duffy
- , A Doszpoly
- & A H Baker
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Original Article |
Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread
- T Shibata
- , H Uchida
- & H Tahara
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Original Article |
Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models
- H Yang
- , T Peng
- & B Liu
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Original Article |
Neuroblastomas vary widely in their sensitivities to herpes simplex virotherapy unrelated to virus receptors and susceptibility
- P-Y Wang
- , H M Swain
- & T P Cripe
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Original Article |
Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs
- B Grubor-Bauk
- , W Yu
- & E J Gowans
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Original Article |
Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice
- R Lakhan
- , D J Baylink
- & X Qin
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Original Article - Enabling Technologies |
Replicating reoviruses with a transgene replacing the codons for the head domain of the viral spike
- D J M van den Wollenberg
- , I J C Dautzenberg
- & R C Hoeben
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Original Article |
Impact of adenovirus life cycle progression on the generation of canine helper-dependent vectors
- P Fernandes
- , D Simão
- & P M Alves
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Short Communication |
Assessment of oncolytic HSV efficacy following increased entry-receptor expression in malignant peripheral nerve sheath tumor cell lines
- J D Jackson
- , A M McMorris
- & K A Cassady
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Short Communication |
Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials
- A L Minella
- , F M Mowat
- & S M Petersen-Jones
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Original Article |
Retinal transduction profiles by high-capacity viral vectors
- A Puppo
- , G Cesi
- & A Auricchio
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Original Article |
Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector
- J Ohtsuka
- , M Fukumura
- & T Nosaka
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Original Article
| Open AccessLong-term functional duration of immune responses to HCV NS3/4A induced by DNA vaccination
- G Ahlén
- , F Holmström
- & L Frelin
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Original Article |
Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A
- I J C Dautzenberg
- , D J M van den Wollenberg
- & R C Hoeben
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Original Article |
Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve
- S A Hoyng
- , S Gnavi
- & J Verhaagen
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Short Communication |
Activity of a group B oncolytic adenovirus (ColoAd1) in whole human blood
- Y Di
- , L Seymour
- & K Fisher
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Original Article |
In vivo safety, biodistribution and antitumor effects of uPAR retargeted oncolytic measles virus in syngeneic cancer models
- Y Jing
- , J Zaias
- & J R Merchan
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Enabling Technologies |
Quantitative morphological comparison of axon-targeting strategies for gene therapies directed to the nigro-striatal projection
- S Padmanabhan
- , T Kareva
- & R E Burke
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Original Article |
Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model
- C Weber
- , I Neacsu
- & S T Pleger
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Original Article |
A compact dual promoter adeno-associated viral vector for efficient delivery of two genes to dorsal root ganglion neurons
- N D Fagoe
- , R Eggers
- & M R J Mason
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Original Article |
In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV
- P S Montenegro-Miranda
- , V Pichard
- & P J Bosma
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Original Article |
Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair
- F Alaee
- , O Sugiyama
- & J R Lieberman
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Original Article |
A novel gene delivery method transduces porcine pancreatic duct epithelial cells
- M A Griffin
- , M S Restrepo
- & A Uc
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Original Article |
Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice
- Q Yu
- , Y Wang
- & X Lin
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Original Article |
Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures
- E-K Kim
- , H-S Seo
- & C-Y Kang
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Original Article |
Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach
- F M Mowat
- , K R Gornik
- & J T Bartoe
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Original Article
| Open AccessAdeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain
- G P Swain
- , M Prociuk
- & C H Vite
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Original Article |
Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain
- W San Sebastian
- , L Samaranch
- & K S Bankiewicz
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