Featured
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Brief Communication
| Open AccessAlternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active
- Luca Giordano
- , Manish K. Aneja
- & Marten Szibor
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Original Article
| Open AccessAdipose tissue: a new target for electroporation-enhanced DNA vaccines
- P D Fisher
- , C J Brambila
- & K E Broderick
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Original Article |
Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer
- T L Mao
- , K F Fan
- & C L Liu
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Original Article |
Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis
- A Tomaru
- , T Kobayashi
- & E C Gabazza
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Original Article
| Open AccessAAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease
- J Miniarikova
- , V Zimmer
- & P Konstantinova
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Review |
Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy
- L Jiang
- , P Vader
- & R M Schiffelers
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Original Article
| Open AccessTherapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
- F DeRosa
- , B Guild
- & M W Heartlein
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Original Article |
Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro
- J C Evans
- , J McCarthy
- & C M O’Driscoll
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Original Article |
Sustained inhibition of hepatitis B virus replication in vivo using RNAi-activating lentiviruses
- D Ivacik
- , A Ely
- & P Arbuthnot
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Original Article |
shRNA-induced saturation of the microRNA pathway in the rat brain
- M A van Gestel
- , S van Erp
- & R A H Adan
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Original Article |
Resistance of transgenic silkworm to BmNPV could be improved by silencing ie-1 and lef-1 genes
- P Zhang
- , J Wang
- & C Gong
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Original Article
| Open AccessTherapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver
- P Maczuga
- , J Verheij
- & P Konstantinova
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Original Article |
Pluronic–PEI copolymers enhance exon-skipping of 2′-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice
- M Wang
- , B Wu
- & Q L Lu
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Original Article
| Open AccessEfficient siRNA transfection to the inner ear through the intact round window by a novel proteidic delivery technology in the chinchilla
- W Qi
- , D Ding
- & Y Guo
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Original Article |
Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53
- A Reschner
- , S Bontems
- & P Delvenne
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Original Article |
Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
- B R Anderson
- , K Karikó
- & D Weissman
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Review |
Using non-coding small RNAs to develop therapies for Huntington's disease
- Y Zhang
- & R M Friedlander
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Original Article |
A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation
- J J M Eekels
- , A O Pasternak
- & B Berkhout
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Review |
Current progress in the development of RNAi-based therapeutics for HIV-1
- J Zhou
- & J J Rossi
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Original Article |
Artificial microRNA interference targeting AT1a receptors in paraventricular nucleus attenuates hypertension in rats
- Z-D Fan
- , L Zhang
- & G-Q Zhu
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Original Article |
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
- G Zhao
- , J Cui
- & C-Y Wang
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Original Article |
Preclinical development of siRNA therapeutics for AL amyloidosis
- B M Hovey
- , J E Ward
- & D C Seldin
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Original Article |
RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors
- T Schaser
- , C Wrede
- & C J Buchholz
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Original Article |
Intratumor RNA interference of cell cycle genes slows down tumor progression
- S Dharmapuri
- , D Peruzzi
- & L Aurisicchio
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Original Article |
Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
- J N Martin
- , N Wolken
- & P Gonzalez-Alegre
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Enabling Technologies
| Open AccessDown-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
- Y Zhang
- , Z Qu
- & I D Horak
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Original Article |
RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency
- S-T Wang
- , C-C Chang
- & C-C Lin
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Original Article |
Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi
- H Guo
- , J Zhang
- & C Inal
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Original Article |
Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models
- S Y Wu
- , A Singhania
- & N A J McMillan
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Original Article |
Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells
- T Kato
- , A Natsume
- & T Wakabayashi
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Original Article |
Lentiviral-mediated Foxp3 RNAi suppresses tumor growth of regulatory T cell-like leukemia in a murine tumor model
- B-Y Tsai
- , J-L Suen
- & B-L Chiang