Microscopy articles within Nature

Featured

  • Letter |

    In situ infrared spectroscopy maps the occurrences of chemical bonds within tiny inclusions in 3,700-million-year-old metasedimentary rocks from West Greenland, finding greater evidence for organic life at this early date.

    • T. Hassenkam
    • , M. P. Andersson
    •  & M. T. Rosing

  • News & Views |

    G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

    • Ching-Ju Tsai
    • , Joerg Standfuss
    •  & Robert M. Glaeser

  • News & Views |

    Biological molecules are often imaged by attaching fluorescent labels — but only a few label types can be used at a time. A method that could smash the record for the number of labels that can be used together is now reported. See Letter p.465

    • Charles H. Camp Jr
    •  & Marcus T. Cicerone

  • Letter |

    Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.

    • Lu Wei
    • , Zhixing Chen
    •  & Wei Min

  • Technology Feature |

    Innovative tools are revealing the forces that guide cellular processes such as embryonic development and tumour growth.

    • Michael Eisenstein

  • Technology Feature |

    Neurobiologists are coming up with innovative ways to get high-resolution pictures of the whole brain at work.

    • Amber Dance

  • Technology Feature |

    A suite of tools now enables scientists to see proteins at work in living cells at the single-molecule level.

    • Marissa Fessenden

  • Letter |

    Luminescence induced by highly localized excitations that are produced by electrons tunnelling from the tip of a scanning tunnelling microscope is used to map the spatial distribution of the excitonic coupling in well-defined arrangements of a few zinc-phthalocyanine molecules and the dependence of this spatial distribution on the relative orientation and phase of the transition dipoles of the individual molecules.

    • Yang Zhang
    • , Yang Luo
    •  & J. G. Hou

  • Letter |

    Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find that transcriptionally active, inactive and Polycomb-repressed chromatin states each have a distinct spatial organisation.

    • Alistair N. Boettiger
    • , Bogdan Bintu
    •  & Xiaowei Zhuang

  • News & Views |

    By infusing blood vessels with gas-filled microbubbles and using rapid ultrasound imaging to detect the bubbles, super-resolution imaging of an entire vessel system has been achieved in a rat brain. See Letter p.499

    • Ben Cox
    •  & Paul Beard

  • Letter |

    Conventional clinical ultrasound imaging has, at best, sub-millimetre-scale resolution, but now a new ultrasound technique is demonstrated that is based on fast tracking of transient signals from a sub-wavelength contrast agent and has sufficiently high resolution to map the microvasculature deep into organs.

    • Claudia Errico
    • , Juliette Pierre
    •  & Mickael Tanter

  • News & Views |

    In plant cells, the pigment anthocyanin is transported to a membrane-bounded organelle called the vacuole for storage. A previously unidentified transport pathway involving vacuolar-membrane extensions mediates this process.

    • Diane C. Bassham

  • Outlook |

    Powerful super-resolution microscopes that allow researchers to explore the world at the nanoscale are set to transform our understanding of the cell.

    • Katherine Bourzac

  • News & Views |

    Artificial neural networks have been combined with microscopy to visualize the 3D structure of biological cells. This could lead to solutions for difficult imaging problems, such as the multiple scattering of light.

    • Laura Waller
    •  & Lei Tian

  • Letter |

    The coherent manipulation of electron quantum states using light, commonly employed in atoms and molecules, is extended to the case of free electron beams using ultrafast transmission electron microscopy; this approach may enable a range of applications in ultrafast electron imaging and spectroscopy down to attosecond precision.

    • Armin Feist
    • , Katharina E. Echternkamp
    •  & Claus Ropers

  • Letter |

    Recent advances in electron microscopy are shown to allow vibrational spectroscopy at high spatial resolution in a scanning transmission electron microscope, and also to enable the direct detection of hydrogen.

    • Ondrej L. Krivanek
    • , Tracy C. Lovejoy
    •  & Peter A. Crozier

  • Outlook |

    Using a variety of creative imaging techniques, researchers are tracking the dynamic interactions of immune and cancer cells. Their results will guide drug development.

    • Katherine Bourzac

  • Letter |

    An innovative technique based on scanning tunnelling probes with integrated thermocouples is developed and used to measure heat dissipation in the electrodes of atomic and molecular junctions.

    • Woochul Lee
    • , Kyeongtae Kim
    •  & Pramod Reddy

  • Article |

    The long-awaited structure of a telomerase holoenzyme, from Tetrahymena, has been obtained by electron microscopy; affinity labelling of subunits and modelling with NMR and crystal structures of various components allowed the identification of the catalytic core and subunit interactions, and the functional role of the subunits in telomerase processivity was enabled by performing the first reconstitution of the holoenzyme in vitro.

    • Jiansen Jiang
    • , Edward J. Miracco
    •  & Juli Feigon

  • Technology Feature |

    Using two different kinds of imaging can give scientists a powerful combination of high specificity and detailed structural information.

    • Caitlin Smith

  • Letter |

    The image of a fluorescent object hidden behind an opaque layer can be retrieved non-invasively by exploiting the correlation properties of the speckle pattern produced by illuminating the object through the layer using laser light.

    • Jacopo Bertolotti
    • , Elbert G. van Putten
    •  & Allard P. Mosk

  • News |

    Photo competition highlights the complexity of microscopic natural specimens.

    • Daniel Cressey

  • Letter |

    A simple and accessible method of probing the nature of bonding on the very surface of a material is reported, using transmission electron microscopy: the technologically important compound strontium titanate is examined as an example.

    • Guo-zhen Zhu
    • , Guillaume Radtke
    •  & Gianluigi A. Botton

  • News & Views |

    An approach to microscopy has been developed that can be used to determine, from a single imaging angle, both the position of a specimen's individual atoms in the plane of observation and the atoms' vertical position. See Letter p.243

    • Dilano Saldin

  • Letter |

    An electron tomography method is demonstrated that can determine the three-dimensional structure of a gold nanoparticle at 2.4 Å resolution, including the locations of some of the individual atoms within the sample.

    • M. C. Scott
    • , Chien-Chun Chen
    •  & Jianwei Miao

  • Technology Feature |

    The tiniest structures in cells can be seen only using sophisticated instrumentation and informatics, but what biologists really need are improved fluorescent probes.

    • Monya Baker

  • News & Views |

    The presence of magnetic moments in materials known as Kondo lattices can lead to an exotic transformation in their properties. The first successful endeavour into imaging such a transformation has now been made. See Letter p.362

    • Piers Coleman

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