Featured
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Article |
Hydration solids
A study shows that water can control macroscopic properties of biological materials through the hydration force, giving rise to a distinct class of solid matter with unusual properties.
- Steven G. Harrellson
- , Michael S. DeLay
- & Ozgur Sahin
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Article
| Open Access
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Using a combination of methods, the mechanism of the antibiotic teixobactin is revealed.
- Rhythm Shukla
- , Francesca Lavore
- & Markus Weingarth
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Article |
Localization atomic force microscopy
A localization algorithm is applied to datasets obtained with conventional and high-speed atomic force microscopy to increase image resolution beyond the limits set by the radius of the tip used.
- George R. Heath
- , Ekaterina Kots
- & Simon Scheuring
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Article |
Imaging single glycans
An imaging method combining soft-landing electrospray ion beam deposition and low-temperature scanning tunnelling microscopy resolves the structures of glycans at sub-nanometre resolution, revealing the connectivity of glycan chains and the types of linkages.
- X. Wu
- , M. Delbianco
- & K. Kern
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Article |
Force-induced conformational changes in PIEZO1
Cryo-electron microscopy and high-speed atomic force microscopy reveal that PIEZO1 can reversibly deform its shape towards a planar structure, which may explain how the PIEZO1 channel is gated in response to mechanical stimulation.
- Yi-Chih Lin
- , Yusong R. Guo
- & Simon Scheuring
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Letter |
Controlling protein assembly on inorganic crystals through designed protein interfaces
The controlled design of arrays of carboxylates geometrically matched to a potassium ion sublattice leads to the formation of extended self-assembled protein structures on mica.
- Harley Pyles
- , Shuai Zhang
- & David Baker
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Letter |
Inertial picobalance reveals fast mass fluctuations in mammalian cells
A picobalance consisting of an optically excited microcantilever has been developed and used to measure the masses of individual healthy and virus-infected cells at high temporal and mass resolutions in culture conditions.
- David Martínez-Martín
- , Gotthold Fläschner
- & Daniel J. Müller
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Letter |
Elements of Eoarchean life trapped in mineral inclusions
In situ infrared spectroscopy maps the occurrences of chemical bonds within tiny inclusions in 3,700-million-year-old metasedimentary rocks from West Greenland, finding greater evidence for organic life at this early date.
- T. Hassenkam
- , M. P. Andersson
- & M. T. Rosing
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Research Highlights |
Achieving spin control
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News |
Feeling the shapes of molecules
The atomic structure of a small organic molecule can be revealed by atomic force microscopy.
- Philip Ball
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Research Highlights |
Imaging: Cell-wall secrets
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News & Views |
When mica and water meet
A neat mode of operation of the atomic force microscope has been used to probe the interface between mica and water. The results help to settle a long-standing debate about the nature of this interface.
- Joost W. M. Frenken
- & Tjerk H. Oosterkamp
A pentameric TRPV3 channel with a dilated pore