Super-resolution microscopy articles within Nature

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  • Article
    | Open Access

    The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off-the-shelf fluorescence microscopy hardware and reagents.

    • Susanne C. M. Reinhardt
    • , Luciano A. Masullo
    •  & Ralf Jungmann

  • Article |

    Functional mutations identified in patients with androgen insensitivity syndrome, in the formin and actin nucleator DAAM2, uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.

    • Julian Knerr
    • , Ralf Werner
    •  & Nadine C. Hornig

  • Article |

    A combination of multiview imaging, structured illumination, reconstruction algorithms and deep-learning predictions realizes spatial- and temporal-resolution improvements in fluorescence microscopy to produce super-resolution images from diffraction-limited input images.

    • Yicong Wu
    • , Xiaofei Han
    •  & Hari Shroff

  • Article
    | Open Access

    Observations of rapid repair of double-stranded DNA breaks in sister choromosomes in Escherichia coli are consistent with a reduced-dimensionality-search model of RecA-mediated repair.

    • Jakub Wiktor
    • , Arvid H. Gynnå
    •  & Johan Elf

  • Article |

    Optical imaging of single-molecule electrochemical reactions in aqueous solution enables super-resolution electrochemiluminescence microscopy, which can be used to monitor the adhesion dynamics of live cells with high spatiotemporal resolution.

    • Jinrun Dong
    • , Yuxian Lu
    •  & Jiandong Feng

  • Letter |

    seqFISH+, an evolution of sequential fluorescence in situ hybridization with super-resolution imaging capabilities, is used to image mRNAs of 10,000 genes in cultured cells and mouse brain slices, demonstrating the ability to generate spatial atlases and to perform discovery-driven studies in situ.

    • Chee-Huat Linus Eng
    • , Michael Lawson
    •  & Long Cai

  • Letter |

    Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.

    • Ai-Hui Tang
    • , Haiwen Chen
    •  & Thomas A. Blanpied

  • Letter |

    Super-resolution imaging provides direct evidence in live cells that membrane fusion and fission are mediated through an intermediate hemi-fused structure, where fusion and calcium/dynamin-dependent fission mechanisms compete to determine the transition of the intermediate to fusion or fission.

    • Wei-Dong Zhao
    • , Edaeni Hamid
    •  & Ling-Gang Wu

  • Letter |

    Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find that transcriptionally active, inactive and Polycomb-repressed chromatin states each have a distinct spatial organisation.

    • Alistair N. Boettiger
    • , Bogdan Bintu
    •  & Xiaowei Zhuang

  • Letter |

    Conventional clinical ultrasound imaging has, at best, sub-millimetre-scale resolution, but now a new ultrasound technique is demonstrated that is based on fast tracking of transient signals from a sub-wavelength contrast agent and has sufficiently high resolution to map the microvasculature deep into organs.

    • Claudia Errico
    • , Juliette Pierre
    •  & Mickael Tanter

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