Nature

Microscopy articles from across Nature Portfolio

Microscopy refers to any method used to acquire images of nearby objects at resolutions that greatly exceed the resolving ability of the unaided human eye. Object visualization may be mediated by light or electron beams using optical or magnetic lenses respectively, or through the use of a physical scanning probe that measures one of a wide range of different sample characteristics.

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Locating dislocations in organic crystals

The formation of dislocations upon slip–slide events in organic crystals has been revealed by advanced electron microscopy and data-mining techniques.
- Oliver Lin
- Zhichu Tang
- Qian Chen
News & Views11 Apr 2025 Nature Materials
P: 1-3
A map of neural signals and circuits traces the logic of brain computation

A large consortium of scientists adds functional data to neuronal wiring maps, seeking to crack the computational circuitry of the mouse brain.
- Mariela D. Petkova
- Gregor F. P. Schuhknecht
News & Views09 Apr 2025 Nature
Volume: 640, P: 319-321

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Latest Research and Reviews

Mapping brain-wide activity networks: brainways as a tool for neurobiological discovery
- Ben Kantor
- Keren Ruzal
- Inbal Ben-Ami Bartal
ResearchOpen Access22 Apr 2025 Neuropsychopharmacology
P: 1-11
New imaging tools reveal live cellular collagen secretion, fibril dynamics and network organisation
- Olivia Kent
- Eleanor R. Casey
- Timothy J. Hawkins
ResearchOpen Access21 Apr 2025 Scientific Reports
Volume: 15, P: 13764
Sidelobe-free deterministic 3D nanoscopy with λ/33 axial resolution

A purely physical, single objective-lens strategy (UNEx-4Pi) for achieving sidelobe-free λ/33 axial resolution by fusion of ultrahighly nonlinear excitation of photon avalanches and mirror-assisted bifocal vector field modulation.
- Binxiong Pan
- Baoju Wang
- Qiuqiang Zhan
ResearchOpen Access21 Apr 2025 Light: Science & Applications
Volume: 14, P: 168
SPECTREPlex: an automated, fast, high-resolution enabled approach for multiplexed cyclic imaging and tissue spatial analysis

A fast, automated, high-resolution, low-cost multiplex immunofluorescence method to understand spatial organization of tissue.
- Michael D. Anderson
- Abigail Plone
- Jay R. Thiagarajah
ResearchOpen Access19 Apr 2025 Communications Biology
Volume: 8, P: 636
Anchor point based image registration for absolute scale topographic structure detection in microscopy
- Zhuo Diao
- Zijie Meng
- Akira Sakai
ResearchOpen Access18 Apr 2025 Scientific Reports
Volume: 15, P: 13486
Imaging 3D cell cultures with optical microscopy

This Review discusses current 2D and 3D microscopy methods for imaging three-dimensional cell cultures and emerging strategies to address key challenges.
- Huai-Ching Hsieh
- Qinghua Han
- Jonathan T. C. Liu
Reviews17 Apr 2025 Nature Methods
P: 1-24

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News and Comment

Locating dislocations in organic crystals

The formation of dislocations upon slip–slide events in organic crystals has been revealed by advanced electron microscopy and data-mining techniques.
- Oliver Lin
- Zhichu Tang
- Qian Chen
News & Views11 Apr 2025 Nature Materials
P: 1-3
A map of neural signals and circuits traces the logic of brain computation

A large consortium of scientists adds functional data to neuronal wiring maps, seeking to crack the computational circuitry of the mouse brain.
- Mariela D. Petkova
- Gregor F. P. Schuhknecht
News & Views09 Apr 2025 Nature
Volume: 640, P: 319-321
An organelle-agnostic image analysis tool
- Michelle Badri
Research Highlights24 Mar 2025 Nature Computational Science
Volume: 5, P: 191
Structural biology at the plasma membrane
- Rita Strack
Research Highlights12 Mar 2025 Nature Methods
Volume: 22, P: 453
A large field of view 2- and 3-photon microscope
- Jack Waters
News & ViewsOpen Access27 Feb 2025 Light: Science & Applications
Volume: 14, P: 106
Visualizing twisted 2D materials with electron channelling contrast imaging

Evan Tillotson describes how scanning electron microscopy imaging can be used to characterize twisted 2D materials.
- Evan Tillotson
Research Highlights07 Feb 2025 Nature Reviews Physics
Volume: 7, P: 134

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