Featured
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Article
| Open AccessDissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
- Xuan Zhou
- , Qian Xiao
- & Xue Li
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Comment
| Open AccessTargeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie.
- Nicole D. Machado
- , Lisa C. Heather
- & Geoff S. Higgins
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The changing nature of HPV associated with high grade cervical lesions in vaccinated populations, a retrospective study of over 1700 cases in Scotland
- Kate Cuschieri
- , Tim Palmer
- & Kirsty Roy
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Article
| Open AccessClassification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
- Junseong Park
- , Jin-Kyoung Shim
- & Seok-Gu Kang
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A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer
- Taiki Hashimoto
- , Daisuke Takayanagi
- & Shigeki Sekine
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Review Article |
Interventional pharmacoeconomics for immune checkpoint inhibitors through alternative dosing strategies
- Austin Wesevich
- , Daniel A. Goldstein
- & Mark J. Ratain
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A clinically practical model for the preoperative prediction of lymph node metastasis in bladder cancer: a multicohort study
- Junlin Lu
- , Jiajian Lai
- & Tianxin Lin
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Article
| Open AccessImpact of BMI on patient outcome in acute myeloid leukaemia patients receiving intensive induction therapy: a real-world registry experience
- Julius C. Enßle
- , Sebastian Wolf
- & Björn Steffen
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Article
| Open AccessA Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma
- Juanita Lopez
- , Julia Lai-Kwon
- & Pablo V. Escribá
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Diagnostic yield of a risk model versus faecal immunochemical test only: a randomised controlled trial in a colorectal cancer screening programme
- Tim L. Kortlever
- , Manon van der Vlugt
- & Evelien Dekker
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Combination of pembrolizumab and pelareorep promotes anti-tumour immunity in advanced pancreatic adenocarcinoma (PDAC)
- Devalingam Mahalingam
- , Siqi Chen
- & Bin Zhang
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Article
| Open AccessThe underestimated impact of excess body weight on colorectal cancer risk: Evidence from the UK Biobank cohort
- Fatemeh Safizadeh
- , Marko Mandic
- & Hermann Brenner
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Review Article
| Open AccessPARP inhibitors: enhancing efficacy through rational combinations
- Deepak Bhamidipati
- , Jaime I. Haro-Silerio
- & Natalie Ngoi
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Article
| Open AccessA tailored phase I-specific patient-reported outcome (PRO) survey to capture the patient experience of symptomatic adverse events
- Helena J. Janse van Rensburg
- , Zhihui Liu
- & Aaron R. Hansen
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Diet quality and lung cancer incidence in a low-income population in the United States
- Heather M. Munro
- , Danxia Yu
- & Martha J. Shrubsole
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Review Article |
Quantitative multiplexed imaging technologies for single-cell analysis to assess predictive markers for immunotherapy in thoracic immuno-oncology: promises and challenges
- Edwin Roger Parra
- , Marius Ilié
- & Paul Hofman
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Article
| Open AccessEfficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer
- Xuhui Dong
- , Jiqiang Fan
- & Yuncheng Bei
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Cancer survivorship and risk of pregnancy complications, adverse obstetric outcomes, and maternal morbidities in female adolescents and young adults: a nationwide population-based study from Taiwan
- Wei-Heng Kao
- , Chang-Fu Kuo
- & Yi-Fang Chuang
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Review Article
| Open AccessRisk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines
- Rebecca L. McCarthy
- , Ellen Copson
- & Ramsey I. Cutress
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A randomised phase 2 study of continuous or intermittent dosing schedule of imatinib re-challenge in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumours
- Hyung-Don Kim
- , Changhoon Yoo
- & Yoon-Koo Kang
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Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
- Seohyuk Lee
- , Chao Ma
- & Jeffrey A. Meyerhardt
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Article
| Open AccessCost-effectiveness analysis of molecular testing in minimally invasive samples to detect endometrial cancer in women with postmenopausal bleeding
- Paula Peremiquel-Trillas
- , David Gómez
- & Mireia Díaz
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Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
- Sierra Cheng
- , John R. McLaughlin
- & Rayjean J. Hung
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‘Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting
- Dikshat Gopal Gupta
- , Neelam Varma
- & Subhash Varma
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Article
| Open AccessClinical biomarker-based biological aging and risk of cancer in the UK Biobank
- Jonathan K. L. Mak
- , Christopher E. McMurran
- & Sara Hägg
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Article
| Open AccessA Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
- Rebecca Kristeleit
- , Ruth Plummer
- & Udai Banerji
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Perspective
| Open AccessThe National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
- Matthew Fittall
- , Justin Liu
- & Lennard Y. W. Lee
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Article
| Open AccessTemporal trends in cardiovascular burden among patients with prostate cancer receiving androgen deprivation therapy: a population-based cohort study
- Jeffrey Shi Kai Chan
- , Danish Iltaf Satti
- & Chi Fai Ng
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Article
| Open AccessOvarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
- Denise G. O’Mahony
- , Susan J. Ramus
- & Elizabeth Santana dos Santos
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Article
| Open AccessTumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer
- Fabian Stögbauer
- , Susanne Beck
- & Jan Budczies
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Article
| Open AccessQuantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420)
- D. Gareth Evans
- , Lorna McWilliams
- & David P. French
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Cancer in Costello syndrome: a systematic review and meta-analysis
- Esteban Astiazaran-Symonds
- , Gina M. Ney
- & Douglas R. Stewart
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Perspective
| Open AccessRevitalising cancer trials post-pandemic: time for reform
- Cienne Morton
- , Richard Sullivan
- & James Spicer
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Article
| Open AccessLong-term risks of invasive cervical cancer following HPV infection: follow-up of two screening cohorts in Manchester
- Clare Gilham
- , Alexandra Sargent
- & Julian Peto
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Targeting unfolded protein response using albumin-encapsulated nanoparticles attenuates temozolomide resistance in glioblastoma
- Karrie Mei-Yee Kiang
- , Wanjun Tang
- & Gilberto Ka-Kit Leung
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Article
| Open AccessAlternative methods to measure breast density in younger women
- Rachel Lloyd
- , Sarah Pirikahu
- & Jennifer Stone
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Perspective
| Open AccessIs it still worth pursuing the repurposing of metformin as a cancer therapeutic?
- Simon R. Lord
- & Adrian L. Harris
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Article
| Open AccessThe HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination
- Lena Mühlenbruch
- , Tsima Abou-Kors
- & Simon Laban
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors and non-small cell lung cancer survival
- Juhua Luo
- , Michael Hendryx
- & Yi Dong
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Review Article
| Open AccessHead and neck cancer patient-derived tumouroid cultures: opportunities and challenges
- B. W. M. Thilini J. Basnayake
- , Paul Leo
- & Chamindie Punyadeera
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Article
| Open AccessImmortal-time bias in older vs younger age groups: a simulation study with application to a population-based cohort of patients with colon cancer
- Sophie Pilleron
- , Camille Maringe
- & Clémence Leyrat
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Article
| Open AccessUse of methotrexate and risk of skin cancer: a nationwide case–control study
- Sam Polesie
- , Martin Gillstedt
- & Kasper Kristensen
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Article
| Open AccessDietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study
- Carlota Castro-Espin
- , Catalina Bonet
- & Antonio Agudo
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Article
| Open AccessPrognostic impact of extracranial disease control in HER2+ breast cancer-related brain metastases
- Michele Bottosso
- , Gaia Griguolo
- & Maria Vittoria Dieci
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Article
| Open AccessConfirmatory prediction-driven RCTs in comparative effectiveness settings for cancer treatment
- Adam Brand
- , Michael C. Sachs
- & Erin E. Gabriel
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High-throughput precision MRI assessment with integrated stack-ensemble deep learning can enhance the preoperative prediction of prostate cancer Gleason grade
- Jie Bao
- , Ying Hou
- & Yu-Dong Zhang
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Comment
| Open AccessThe Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care
- Maria Antonietta Cerone
- , Tara C. Mills
- & Abdullah Alvi
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PI-RADSAI: introducing a new human-in-the-loop AI model for prostate cancer diagnosis based on MRI
- Ruiqi Yu
- , Ke-wen Jiang
- & Yu-Dong Zhang