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Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience
Dendritic protein synthesis is implicated in synaptic plasticity and memory storage. Ainsley et al., develop a method for collecting ribosome-bound mRNAs from mouse brain dendrites, and use RNA sequencing to characterize dendritic mRNAs that bind to ribosomes after mice experience a novel environment.
- Joshua A. Ainsley
- , Laurel Drane
- & Leon G. Reijmers
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| Open AccessLight and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans
Cold tolerance in Caenorhabditis elegansis regulated by signalling pathways and neuronal circuits, but the exact mechanisms are unclear. Here the authors show that cold tolerance requires activity from specific light and pheromone-sensing neurons that release insulin to regulate gene expression in the intestine.
- Akane Ohta
- , Tomoyo Ujisawa
- & Atsushi Kuhara
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Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing
The microtubule-associated protein stathmin is implicated in cognitive processing but it is unclear how. Here, the authors show that stathmin regulates microtubule stability and dendritic transport of specific AMPA receptor subunits, and that this regulation is impaired in aged mice.
- Shusaku Uchida
- , Guillaume Martel
- & Gleb P. Shumyatsky
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The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections
The intracellular redox protein MICAL plays an important role during Drosophilanervous system development but the function of its vertebrate homologue remains unknown. Here the authors show that MICAL-1 regulates targeting of secretory vesicles containing IgCAMs to the neuronal growth cone in mice and plays a role in hippocampal connectivity.
- Eljo Y. Van Battum
- , Rou-Afza F. Gunput
- & R. Jeroen Pasterkamp
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| Open AccessThe correlation between reading and mathematics ability at age twelve has a substantial genetic component
Understanding the genetic basis of cognitive traits could aid the development of numeracy and literacy skills in children. Here the authors show that reading and mathematics have a large overlapping genetic component and suggest that a child's learning environment has a key role in creating differences between them.
- Oliver S. P. Davis
- , Gavin Band
- & Chris C. A. Spencer
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pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning
The protein kinase CaMKII modulates synaptic plasticity and learning in both vertebrate and invertebrate organisms. In this study, the authors demonstrate a role for autophosphorylated CaMKII (pT305-CaMKII) in maintaining memory consolidation after classical conditioning in the invertebrate species Lymnaea.
- Souvik Naskar
- , Huimin Wan
- & György Kemenes
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Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons
Striatal cholinergic interneurons are implicated in various behaviours and cognitive processes. Here, Okada et al. selectively ablate these interneurons in rats and show that cholinergic interneurons inhibit place reversal learning through M4, but not M1 muscarinic receptors.
- Kana Okada
- , Kayo Nishizawa
- & Kazuto Kobayashi
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Consistent individual differences in human social learning strategies
Social learning is crucial to the evolutionary success of humans. Here, the authors evaluate social learning strategies in a sample of human subjects and find that some individuals imitate the behaviours of their most successful peers, while others conform to the behaviour of the majority.
- Lucas Molleman
- , Pieter van den Berg
- & Franz J. Weissing
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Practice and sleep form different aspects of skill
Sleep is implicated in consolidating procedural skills. Here, Song and Cohen train subjects on a repeating sequence of key-presses and show that practice contributes to transitional information-based aspects of skill whereas sleep contributes to ordinal information-based aspects of skill.
- Sunbin Song
- & Leonardo G. Cohen
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| Open AccessTemporally selective contextual encoding in the dentate gyrus of the hippocampus
The dentate gyrus of the hippocampus is required for processing the temporal context of memories. Here, Rangel et al.identify neurons in the rat dentate gyrus that also process the temporal separation between multiple experiences.
- L.M. Rangel
- , A.S. Alexander
- & L.K. Quinn
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A molecular brake controls the magnitude of long-term potentiation
Suprachiasmatic nucleus circadian oscillatory protein (SCOP) is implicated in long-term potentiation. Here, the authors show that μ-calpain-mediated SCOP degradation contributes to long-term potentiation induction, whereas m-calpain-mediated stimulation of SCOP synthesis restricts long-term potentiation.
- Yubin Wang
- , Guoqi Zhu
- & Michel Baudry
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Predictive codes of familiarity and context during the perceptual learning of facial identities
Predictive coding by neural circuits is implicated in visual perception and recognition. Apps and Tsakiris show that contextual familiarity is processed by the superior temporal sulcus and that prediction errors that update facial familiarity are processed by the fusiform face area.
- Matthew A. J. Apps
- & Manos Tsakiris
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| Open AccessA cholinergic trigger drives learning-induced plasticity at hippocampal synapses
Cholinergic signalling modulates learning and memory; however, its influence on learning-induced synaptic plasticity is less clear. Mitsushima et al.show that acetylcholine simultaneously strengthens both excitatory and inhibitory synapses onto CA1 pyramidal neurons following an inhibitory avoidance task.
- Dai Mitsushima
- , Akane Sano
- & Takuya Takahashi
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Circuit reactivation dynamically regulates synaptic plasticity in neocortex
Slow-wave neural activity, which comprises up and down states, regulates long-term potentiation. Kruskal et al. show that endogenous neural circuit activity corresponding to up states acts as a potent and dynamic promoter of long-term potentiation.
- Peter B. Kruskal
- , Lucy Li
- & Jason N MacLean
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| Open AccessRole of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice
Motor cortex NMDA receptors have a key role in the acquisition of associative memories. Hasan et al. generate mice lacking NMDA receptor activity in the motor cortex and find that this impairs LTP, strengthening of synapses between somatosensory and motor cortices, and associative learning.
- Mazahir T. Hasan
- , Samuel Hernández-González
- & José M. Delgado-García
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Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans
Salt chemotaxis behaviour inCaenorhabditis elegansis partly dependent on previous experiences of starvation. In this study, the authors show that this learned behaviour is due to experience-dependent plasticity in a subset of gustatory neurons.
- Hirofumi Kunitomo
- , Hirofumi Sato
- & Yuichi Iino
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Rudimentary substrates for vocal learning in a suboscine
Vocal learning is a feature that is specific to some species of mammals and birds, including oscine songbirds. Liu et alstudy the vocal, non-learning, eastern phoebe suboscine, and find that it uses the forebrain to control the vocal-motor system, similar to vocal learning oscines.
- Wan-chun Liu
- , Kazuhiro Wada
- & Fernando Nottebohm
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| Open AccessExperience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus
Gamma oscillations act to synchronize neuronal activity and are implicated in cognitive processing. Using in vivo electrophysiology, Shinohara et al. find that gamma oscillations and associated structural changes are greater in right-sided hippocampi of enriched environment-reared rats.
- Yoshiaki Shinohara
- , Aki Hosoya
- & Hajime Hirase
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| Open AccessSusceptibility of memory consolidation during lapses in recall
Memory lapses during memory consolidation are periods when the memory becomes briefly inaccessible after its formation. Marra and colleagues study memory lapses in the mollusc Lymnaea, and find that only during these lapses is consolidation of memories susceptible to interruption by external disturbances.
- Vincenzo Marra
- , Michael O’Shea
- & Ildikó Kemenes
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Dimensionality of brain networks linked to life-long individual differences in self-control
The ability to delay gratification in childhood correlates with the ability to exert self-control in adulthood. Berman and colleagues re-examine individuals that were studied 40 years ago and find that the individuals who are able to exert a high level of self-control have more efficient neural networks.
- Marc G. Berman
- , Grigori Yourganov
- & John Jonides
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| Open AccessPioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus
The heterogeneity of cortical interneurons results from spatio-temporal differences in embryonic origin. Marissal et al. show that early-generated glutamatergic neurons display distinct morpho-functional features, suggesting that temporal factors are also important in determining glutamatergic function.
- Thomas Marissal
- , Paolo Bonifazi
- & Rosa Cossart
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Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region
The dentate gyrus and CA3 of the hippocampus are involved in pattern separation. Niibori and colleagues investigate the role of adult hippocampal neurogenesis in pattern separation and find that suppressing adult neurogenesis in the dentate gyrus impairs coding of similar, but not dissimilar contexts.
- Yosuke Niibori
- , Tzong-Shiue Yu
- & Paul W. Frankland
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Variability in the quality of visual working memory
Working memory is vital for individuals to carry out everyday activities. Fougnie and colleagues ask subjects to perform memory tasks and find that the precision of working memory varies independently across trials and items, which is inconsistent with the assumptions of standard models of memory.
- Daryl Fougnie
- , Jordan W. Suchow
- & George A. Alvarez
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| Open AccessThyroid hormone determines the start of the sensitive period of imprinting and primes later learning
Filial imprinting allows precocial birds to form social attachment to other animals or objects soon after hatching. Yamaguchi and colleagues investigate the mechanisms responsible for this, and find that thyroid hormones circulating in the plasma regulate the sensitive period during which imprinting occurs.
- Shinji Yamaguchi
- , Naoya Aoki
- & Koichi J. Homma
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Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
Changes in gene expression in the hippocampus and the cortex are pivotal for memory consolidation. Gräff and colleagues use a recognition task in mice to show that epigenetic post-translational modifications are rapidly activated in the hippocampus after learning, but induced with a delay in the cortex.
- Johannes Gräff
- , Bisrat T. Woldemichael
- & Isabelle M. Mansuy
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| Open AccessExtrasynaptic vesicle recycling in mature hippocampal neurons
In the classical model, fast neuronal signalling occurs at specialized presynaptic terminals. Now, Ratnayakaet al. show that stimulus-driven fusion and recycling of synaptic vesicles can occur at axonal sites remote from conventional synapses. These findings have implications for dynamic forms of neuron–neuron communication.
- Arjuna Ratnayaka
- , Vincenzo Marra
- & Kevin Staras
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Behavioural memory reconsolidation of food and fear memories
Memory retrieval followed by extinction training has been shown to erase fear memories. Flavellet al. show that this approach also erases appetitive memories in rats and results from a modification of memory reconsolidation, which could be useful for the treatment of drug addiction.
- Charlotte R. Flavell
- , David J. Barber
- & Jonathan L.C. Lee
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| Open AccessIh-mediated depolarization enhances the temporal precision of neuronal integration
In neurons, GABAA receptors mediate feed-forward inhibition by shunting excitatory currents and hyperpolarizing neurons. Here, the authors show that the hyperpolarization-activated mixed cation current is critical for determining the resting membrane potential and reversal potential for GABAA-mediated currents.
- Ivan Pavlov
- , Annalisa Scimemi
- & Matthew C. Walker
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| Open AccessInnate recognition of water bodies in echolocating bats
Little is known about the way bats recognize large objects, such as trees, buildings or a lake. Greif and Siemers show that bodies of water are recognized solely by echolocation, and that this ability is innate, thus smooth surfaces are recognized as water by naive juvenile bats.
- Stefan Greif
- & Björn M. Siemers