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| Open AccessThe behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain
How animals learn that reward is predicted by multi-event sequences consisting of sensory stimuli and actions remains poorly understood. Here, the authors show that such learning starts from the event closest to the reward and sequentially incorporates earlier events.
- Hachi E. Manzur
- , Ksenia Vlasov
- & Shih-Chieh Lin
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| Open AccessNucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice
Lateral hypothalamus (LH) plays an role in drug addiction. Here, authors present evidence for disinhibited LH glutamatergic neurons by neural circuits from nucleus accumbens to contribute to context-induced expression of morphine withdrawal memory.
- Huan Sheng
- , Chao Lei
- & Ping Zheng
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| Open AccessBrainstem networks construct threat probability and prediction error from neuronal building blocks
The prevailing view of threat computation is a division of labor in which the forebrain signals threat and the brainstem organizes behavior. Using neuropixels, the authors show that brainstem neurons organize into a functional network to signal threat.
- Jasmin A. Strickland
- & Michael A. McDannald
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| Open AccessContext value updating and multidimensional neuronal encoding in the retrosplenial cortex
Goal-directed behaviors require the brain to integrate information across many task-related dimensions. Here, the authors use a virtual context discrimination paradigm in mice to demonstrate the capacity for neurons in the retrosplenial cortex to exhibit multidimensional encoding across learning.
- Weilun Sun
- , Ilseob Choi
- & Alexander Dityatev
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| Open AccessLearning with reinforcement prediction errors in a model of the Drosophila mushroom body
Dopamine neurons in the mushroom body help Drosophila learn to approach rewards and avoid punishments. Here, the authors propose a model in which dopaminergic learning signals encode reinforcement prediction errors by utilising feedback reinforcement predictions from mushroom body output neurons.
- James E. M. Bennett
- , Andrew Philippides
- & Thomas Nowotny
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| Open AccessSex differences in fear memory consolidation via Tac2 signaling in mice
The Tachykinin 2 (Tac2) pathway in the central amygdala is sufficient and necessary for modulating fear memory consolidation. The authors show that silencing Tac2 neurons in the amygdala of male mice reduces fear expression, while fear expression in female mice is increased when manipulations are made during proestrus.
- A. Florido
- , E. R. Velasco
- & R. Andero
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| Open AccessSingle-neuron representation of learned complex sounds in the auditory cortex
Using a combination of two-photon imaging and single-cell electrophysiology, the authors discover that associative learning induces the emergence of a unique subset of neurons in the auditory cortex, exhibiting high-rate bursting responses to the learned complex sounds but not to any of the constituents.
- Meng Wang
- , Xiang Liao
- & Xiaowei Chen
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| Open AccessPhasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction
It is not entirely understood how network plasticity produces the coding of predicted value during stimulus-outcome learning. Here, the authors reveal a reinforcing loop in distributed limbic circuits, transforming sensory stimuli into reward prediction coding broadcasted by dopamine neurons to the brain.
- Lars-Lennart Oettl
- , Max Scheller
- & Wolfgang Kelsch
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| Open AccessDopamine transients do not act as model-free prediction errors during associative learning
Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. Here, the authors show that when given during an associative learning task, optogenetic activation of dopamine neurons causes associative, rather than value, learning.
- Melissa J. Sharpe
- , Hannah M. Batchelor
- & Geoffrey Schoenbaum
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| Open AccessAnti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues
Drug addiction is a chronic disorder and many sufferers experience relapses even after a period of successful abstinence. Here, the authors reveal a subset of neurons in the rat infralimbic cortex that suppresses relapse into cocaine or alcohol use by responding to drug-omission cues.
- Amanda Laque
- , Genna L. De Ness
- & Nobuyoshi Suto
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| Open AccessEngram-specific transcriptome profiling of contextual memory consolidation
The molecular mechanisms underlying contextual fear memory consolidation by sparse dentate gyrus (DG) neuronal populations remain unclear. Here using unbiased RNA sequencing of DG engram neurons the authors identify persistent transcriptome modifications during memory consolidation, in which CREB-dependent transcription features prominently
- Priyanka Rao-Ruiz
- , Jonathan J. Couey
- & Steven A. Kushner
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| Open AccessCortical recruitment determines learning dynamics and strategy
Sounds vary in the strength of behavioural conditioning they can evoke, a property attributed to stimulus salience. Here, the authors show that stimulus salience the overall level of neuronal activity recruited in the auditory cortex is strongly related with its reinforcing strength.
- Sebastian Ceballo
- , Jacques Bourg
- & Brice Bathellier
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Article
| Open AccessEvidence for model-based encoding of Pavlovian contingencies in the human brain
Pavlovian conditioning involves model-free learning that associates predictive stimuli with their outcome value. Here, the authors present evidence for activation of OFC and striatum that is consistent with model based information during a pavlovian task with multiple stimuli that predict rewards.
- Wolfgang M. Pauli
- , Giovanni Gentile
- & John P. O’Doherty
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| Open AccessPopulation coding of valence in the basolateral amygdala
It is unclear how the basolateral amygdala (BLA) contributes to behaviors driven by aversive or appetitive stimuli. Here, authors simultaneously record the activities of ensembles of BLA neurons in behaving mice to show that distinct but spatially intermingled BLA populations respond to either reward or punishment and that associative learning transforms BLA population activities to represent specific valences
- Xian Zhang
- & Bo Li
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| Open AccessNeural correlates of two different types of extinction learning in the amygdala central nucleus
There are two forms of extinction learning, which are vital for adaptive behaviour: simple extinction, when an expected outcome fails to occur, and overexpectation, when an exaggerated expectation is in conflict with the actual outcome. Iordanova et al.show that both forms of extinction learning have a common neural substrate in the amygdala.
- Mihaela D. Iordanova
- , Mickael L. D. Deroche
- & Geoffrey Schoenbaum
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Article |
pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning
The protein kinase CaMKII modulates synaptic plasticity and learning in both vertebrate and invertebrate organisms. In this study, the authors demonstrate a role for autophosphorylated CaMKII (pT305-CaMKII) in maintaining memory consolidation after classical conditioning in the invertebrate species Lymnaea.
- Souvik Naskar
- , Huimin Wan
- & György Kemenes