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| Open AccessStriatum-projecting prefrontal cortex neurons support working memory maintenance
Lesions of dorsomedial, but not dorsolateral, striatum are associated with working memory impairments. Here, the authors investigate the role of a projection from medial prefrontal cortex to dorsomedial striatum in the maintenance of information during a working memory task in mice.
- Maria Wilhelm
- , Yaroslav Sych
- & Fritjof Helmchen
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| Open AccessOligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice
How and to what extent oligodendrocytes (OLs) contribute to learning and cognition is not well understood. Here, the authors show that the performance of mice in working memory-dependent cognitive tasks depends on OL genesis and is proportional to the number of OL precursors and OLs generated during training.
- Takahiro Shimizu
- , Stuart G. Nayar
- & William D. Richardson
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| Open AccessCycles of goal silencing and reactivation underlie complex problem-solving in primate frontal and parietal cortex
Simple working memory tasks show sustained neural firing in frontal and parietal cortex. Here, the authors show cycles of target silencing and reactivation that are more restricted to single targets in parietal than frontal cortex.
- Kei Watanabe
- , Mikiko Kadohisa
- & John Duncan
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| Open AccessFunctional specialization and interaction in the amygdala-hippocampus circuit during working memory processing
The function of the hippocampus and the amygdala in working memory are still not well understood. Here, the authors identified a functional specialization within the amygdala-hippocampal circuit and stage-dependent information flow during working memory.
- Jin Li
- , Dan Cao
- & Tianzi Jiang
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| Open AccessA rapid theta network mechanism for flexible information encoding
Filtering or gating relevant information into working memory has been attributed to the striatum. Here, the authors reveal neocortical filtering mechanisms, namely, rapid changes in oscillatory theta networks, that predict fast and flexible human behavior.
- Elizabeth L. Johnson
- , Jack J. Lin
- & David Badre
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| Open AccessWorking memory control dynamics follow principles of spatial computing
It is unclear how cognitive computations are performed on sensory information. Here, neural evidence from working memory tasks suggests that the physical dimensions of cortical networks are used to update the status of sensory representations.
- Mikael Lundqvist
- , Scott L. Brincat
- & Pawel Herman
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| Open AccessLow-dimensional encoding of decisions in parietal cortex reflects long-term training history
Posterior parietal cortex supports visual categorization in macaque monkeys. Here, the authors quantify low-dimensional neural population activity using tensor regression to find that long term training history impacts encoding of categorization.
- Kenneth W. Latimer
- & David J. Freedman
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| Open AccessStriatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning
The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity.
- Ruben van den Bosch
- , Britt Lambregts
- & Roshan Cools
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| Open AccessFixational drift is driven by diffusive dynamics in central neural circuitry
Between saccades, our eyes undergo random movements called fixational drift, but what drives this motion has remained elusive. In this paper, the authors demonstrate that a central neural circuit within the oculomotor system drives fixational drift.
- Nadav Ben-Shushan
- , Nimrod Shaham
- & Yoram Burak
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| Open AccessPrefrontal cortical plasticity during learning of cognitive tasks
It remains unclear whether improvements in one cognitive task transfer to other tasks. Here, the authors show that changes in prefrontal neuronal activation, firing rate, and local field potentials induced during active learning of a working memory task are also evident in a control task.
- Hua Tang
- , Mitchell R. Riley
- & Christos Constantinidis
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| Open AccessConcept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts
It is unclear how distinct concepts are processed in the brain. Here, the authors recorded from concept cells in human subjects with epilepsy and found that a subset of concept cells responded to non-preferred concepts if those non-preferred concepts required comparison to a preferred concept.
- Marcel Bausch
- , Johannes Niediek
- & Florian Mormann
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| Open AccessWorking memory representations in visual cortex mediate distraction effects
The relative roles of visual, parietal, and frontal cortex in working memory have been actively debated. Here, the authors show that distraction impacts visual working memory representations in primary visual areas, indicating that these regions play a key role in the maintenance of working memory.
- Grace E. Hallenbeck
- , Thomas C. Sprague
- & Clayton E. Curtis
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| Open AccessParallel processing of working memory and temporal information by distinct types of cortical projection neurons
Intratelencephalic and pyramidal tract neurons are two major types of cortical excitatory neurons that project to cortical and subcortical structures. The authors show that in the prefrontal cortex the two populations have different roles for the maintenance of working memory and for tracking the passage of time.
- Jung Won Bae
- , Huijeong Jeong
- & Min Whan Jung
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| Open AccessFrontotemporal coordination predicts working memory performance and its local neural signatures
Here, the authors show that beta-band coordination between prefrontal and temporal cortex predicts working memory performance. Moreover, inferior temporal neurons exhibits greater memory activity when coordination between these areas is high, suggesting that this interaction supports object memory maintenance.
- Ehsan Rezayat
- , Mohammad-Reza A. Dehaqani
- & Behrad Noudoost
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| Open AccessReduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.
- Heike Stein
- , Joao Barbosa
- & Albert Compte
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| Open AccessMultimodal network dynamics underpinning working memory
Working memory is a critical component of executive function that allows people to complete complex tasks in the moment. Here, the authors show that this ability is underpinned by two newly defined brain networks.
- Andrew C. Murphy
- , Maxwell A. Bertolero
- & Danielle S. Bassett
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| Open AccessThe lateralization of left hippocampal CA3 during the retrieval of spatial working memory
The CA3 region of the hippocampus is involved in spatial working memory. Here, the authors show that neurons in the left CA3 are more active in the choice phase of correct trials of spatial working memory than neurons in the right CA3, revealing lateralization of spatial working memory.
- Da Song
- , Deheng Wang
- & Hong Qing
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| Open AccessDynamic reconfiguration of functional brain networks during working memory training
Working memory training reshapes the brain functional network reorganization. Here, the authors demonstrate an increase of the whole-brain network segregation during the n-back task, accompanied by alterations in dynamic communication between the default mode system and task-positive systems.
- Karolina Finc
- , Kamil Bonna
- & Danielle S. Bassett
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| Open AccessTrajectory-modulated hippocampal neurons persist throughout memory-guided navigation
Trajectory-coding neurons in the hippocampus convey important information for performing memory tasks. Here, Kinsky et al. track long-term neural activity in the hippocampus to find that trajectory-coding emerges rapidly and remains stable across long time-scales.
- Nathaniel R. Kinsky
- , William Mau
- & Michael E. Hasselmo
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| Open AccessPhase-dependent amplification of working memory content and performance
Neuronal patterns during working memory show low-frequency oscillatory activity. Here, the authors demonstrate a rhythmic retention of working memory information in theta and alpha frequency ranges. Moreover, phase-locked amplification of the retained information improves working memory performance.
- Sanne ten Oever
- , Peter De Weerd
- & Alexander T. Sack
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| Open AccessEnsemble representations reveal distinct neural coding of visual working memory
People can easily extract task-relevant gist features from visual scenes and hold those features in working memory. Here, the authors show that this gist information is gradually abstracted from posterior to anterior regions of the brain and stably represented at the anterior region.
- Byung-Il Oh
- , Yee-Joon Kim
- & Min-Suk Kang
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| Open AccessDynamic regulation of interregional cortical communication by slow brain oscillations during working memory
Working memory involves a fronto-parietal brain network, but how the parts of this network are coordinated is unclear. Here, the authors show that fast brain activity at posterior sites is nested into prefrontal slow brain waves, with cognitive demand determining the slow wave phase involved.
- B. Berger
- , B. Griesmayr
- & P. Sauseng
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| Open AccessMemory-guided microsaccades
Microsaccades are small-amplitude, fixational eye movements that are largely thought to be involuntary. Here, the authors demonstrate that monkeys (and humans) can be easily trained to respond to a remembered target location with a volitional microsaccade, and that a population of superior colliculus neurons is selectively associated with them.
- Konstantin F. Willeke
- , Xiaoguang Tian
- & Ziad M. Hafed
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| Open AccessError-correcting dynamics in visual working memory
Neural representations in working memory are susceptible to internal noise, which scales with memory load. Here, the authors show that attractor dynamics mitigate the influence of internal noise by pulling memories towards a few stable representations.
- Matthew F. Panichello
- , Brian DePasquale
- & Timothy J. Buschman
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| Open AccessCerebellar disruption impairs working memory during evidence accumulation
Disruption of cerebellar activity impairs working memory during evidence accumulation in mice. Here, the authors show that optogenetic perturbation of Purkinje cell activity disrupts the accurate accumulation of somatosensory information in working memory during perceptual decision-making.
- Ben Deverett
- , Mikhail Kislin
- & Samuel S.-H. Wang
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| Open AccessDynamic network coding of working-memory domains and working-memory processes
Early neuropsychological studies suggested that different aspects of working memory (WM) are exclusively associated with specific brain areas. Here, the authors show, using machine-learning analysis of fMRI, how WM processes are dynamically coded by large-scale overlapping networks in the human brain.
- Eyal Soreq
- , Robert Leech
- & Adam Hampshire
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| Open AccessAnterior-posterior gradient of plasticity in primate prefrontal cortex
Studies of the functional organization of the prefrontal cortex have produced contradicting results depending on the task used. Here, Riley and colleagues demonstrate that prefrontal areas are specialized across the anterior posterior axis and that the effects of the task themselves impact more the anterior areas.
- Mitchell R. Riley
- , Xue-Lian Qi
- & Christos Constantinidis
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| Open AccessReconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex
Working memory (WM) is represented in persistent activity of single neurons as well as a dynamic population code. Here, the authors find that neurons flexibly switch their coding according to current attention while those with stable resting activity maintain WM representations through dynamic activity patterns.
- Sean E. Cavanagh
- , John P. Towers
- & Steven W. Kennerley
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| Open AccessIntrinsic neuronal dynamics predict distinct functional roles during working memory
Prefrontal neurons exhibit both transient and persistent firing in working memory tasks. Here the authors report that the intrinsic timescale of neuronal firing outside the task is predictive of the temporal dynamics of coding during working memory in three frontoparietal brain areas.
- D. F. Wasmuht
- , E. Spaak
- & M. G. Stokes
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| Open AccessImpaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression
Disrupted dopamine neuron firing is thought to contribute to cognitive dysfunction in psychiatric disorders. Here the authors show that mice overexpressing D2R in the striatum, commonly seen in schizophrenia, are also impaired in recruitment of dopamine neurons during working memory performance.
- Sevil Duvarci
- , Eleanor H. Simpson
- & Torfi Sigurdsson
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| Open AccessGamma and beta bursts during working memory readout suggest roles in its volitional control
Previously, the authors have shown that working memory can be maintained by brief gamma oscillation bursts. Here, the authors use a new task to further demonstrate the dynamics of gamma and beta oscillations in working memory readout, independent of behavioral response.
- Mikael Lundqvist
- , Pawel Herman
- & Earl K. Miller
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| Open AccessReactivation of associative structure specific outcome responses during prospective evaluation in reward-based choices
How the brain evaluates options to make a reward-based choice is unclear. Here, authors show that, prior to choice, neural activity patterns to the potential outcomes are reactivated in macaque orbitofrontal cortex, in a way that reflects the unique event sequences leading up to the outcomes.
- Maya Zhe Wang
- & Benjamin Y. Hayden
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| Open AccessNeuronal population coding of perceived and memorized visual features in the lateral prefrontal cortex
Neurons in the lateral prefrontal cortex are known to encode visual features as well as maintain them in working memory. Here the authors report that LPFC neurons encode both perceived and memorized visual features in diverse combinations and the population activity reliably decodes as well as differentiates between these two representations.
- Diego Mendoza-Halliday
- & Julio C. Martinez-Trujillo
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| Open AccessNeural correlates of working memory development in adolescent primates
Working memory is known to improve through adolescence into adulthood, yet the associated changes in neuronal activity are not well understood. Zhou and colleagues report increased delay period activity correlated with changes in performance on working memory tasks in monkeys as they transition into adulthood.
- Xin Zhou
- , Dantong Zhu
- & Christos Constantinidis
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| Open AccessIntegration and segregation of large-scale brain networks during short-term task automatization
Humans can quickly learn to efficiently execute tasks yet how the brain activity is dynamically reconfigured during this process remains unknown. Here the authors demonstrate that large-scale functional brain networks are reorganized flexibly to support rapid task automation.
- Holger Mohr
- , Uta Wolfensteller
- & Hannes Ruge
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| Open AccessSurprise disrupts cognition via a fronto-basal ganglia suppressive mechanism
Surprising events affect ongoing behaviour and cognitive processing, yet the underlying neural mechanisms remain unclear. Wessel and colleagues show that surprise recruits a motor suppression mechanism which may be implemented via the sub-thalamic nucleus and interrupts working memory performance.
- Jan R. Wessel
- , Ned Jenkinson
- & Adam R. Aron
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The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion
Persistent neural activity underlies working memories and behaviors that require short-term information retention; the mechanisms enabling this, however, are unclear. Here the authors show that the NCA Na+ leak channel is required for the persistent motor circuit activity that sustains locomotion in C. elegans.
- Shangbang Gao
- , Lin Xie
- & Mei Zhen
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| Open AccessCompetition between items in working memory leads to forgetting
Rapidly switching the focus of attention is believed to impair memory, but it is unclear how. Lewis-Peacock and Norman use brain imaging and multivariate analysis to show that when two memories briefly and closely compete in the brain, there is a lasting impairment in the ability to remember these thoughts.
- Jarrod A. Lewis-Peacock
- & Kenneth A. Norman
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Dynamic encoding of face information in the human fusiform gyrus
The human fusiform face area (FFA) plays a major role in face recognition. Ghuman et al.study the temporal dynamics of face information processing in the FFA and establish the timecourse of information processing as well as the processing stages that FFA contributes to when a face is first viewed.
- Avniel Singh Ghuman
- , Nicolas M. Brunet
- & R. Mark Richardson
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Dimensionality of brain networks linked to life-long individual differences in self-control
The ability to delay gratification in childhood correlates with the ability to exert self-control in adulthood. Berman and colleagues re-examine individuals that were studied 40 years ago and find that the individuals who are able to exert a high level of self-control have more efficient neural networks.
- Marc G. Berman
- , Grigori Yourganov
- & John Jonides
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Variability in the quality of visual working memory
Working memory is vital for individuals to carry out everyday activities. Fougnie and colleagues ask subjects to perform memory tasks and find that the precision of working memory varies independently across trials and items, which is inconsistent with the assumptions of standard models of memory.
- Daryl Fougnie
- , Jordan W. Suchow
- & George A. Alvarez