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Article
| Open Access
Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
- Sarah Klinnert
- , Corinne D. Schenkel
- & Karin J. Metzner
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Perspective |
Adeno-associated virus vectors and neurotoxicity—lessons from preclinical and human studies
- Daniel Stone
- , Martine Aubert
- & Keith R. Jerome
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Article |
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep
- Amira D. Rghei
- , Laura P. van Lieshout
- & Sarah K. Wootton
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Review Article |
Prospects of viral vector-mediated delivery of sequences encoding anti-HBV designer endonucleases
- Ridhwaanah Jacobs
- , Prashika Singh
- & Mohube Betty Maepa
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Article
| Open Access
Optimisation of a TALE nuclease targeting the HIV co-receptor CCR5 for clinical application
- Lea Isabell Schwarze
- , Dawid Głów
- & Boris Fehse
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Article
| Open Access
Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients
- Lea Isabell Schwarze
- , Tanja Sonntag
- & Boris Fehse
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Brief Communication |
Host antibacterial defense of 6–10 Gy γ-irradiated mice subjected to lentiviral vector-based Gas5 gene therapy
- Ichiaki Ito
- , Bradford D. Loucas
- & Fujio Suzuki
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Brief Communication |
Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility
- G. Ian Gallicano
- , John L. Casey
- & Samiksha Mahapatra
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Review Article |
Self-amplifying RNA vaccines for infectious diseases
- Kristie Bloom
- , Fiona van den Berg
- & Patrick Arbuthnot
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Brief Communication |
Nanosphere-mediated co-delivery of VEGF-A and PDGF-B genes for accelerating diabetic foot ulcers healing in rats
- Rongfeng Shi
- , Weishuai Lian
- & Maoquan Li
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Brief Communication |
Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia
- Vladislav Dolgachev
- , Sreehari Panicker
- & David Machado-Aranda
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Short Communication
| Open Access
Time-series oligonucleotide count to assign antiviral siRNAs with long utility fit in the big data era
- K Wada
- , Y Wada
- & T Ikemura
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Review |
The state of gene therapy research in Africa, its significance and implications for the future
- P Arbuthnot
- , M B Maepa
- & M S Pepper
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Original Article |
Silencing of HIV-1 by AgoshRNA molecules
- E Herrera-Carrillo
- , A Harwig
- & B Berkhout
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Review |
Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
- S Guan
- & J Rosenecker
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Original Article |
Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia
- V A Dolgachev
- , R Goldberg
- & D Machado-Aranda
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Original Article |
T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates
- C S Rollier
- , E J Verschoor
- & J L Heeney
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Short Communication |
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
- R Kaminski
- , R Bella
- & K Khalili
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Original Article |
Gene transfer of two entry inhibitors protects CD4+ T cell from HIV-1 infection in humanized mice
- N Y Petit
- , C Baillou
- & G Marodon
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Original Article |
Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs
- B Grubor-Bauk
- , W Yu
- & E J Gowans
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Short Communication |
Combinatorial hematopoietic stem cell transplantation and vaccination reduces viral pathogenesis following SHIV89.6P-challenge
- P M Younan
- , P Polacino
- & H-P Kiem
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Original Article |
Inhalation of recombinant adenovirus expressing granulysin protects mice infected with Mycobacterium tuberculosis
- J Ma
- , J Lu
- & X Fan
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Original Article |
Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge
- H Zhang
- , X Tang
- & D Zhou
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Original Article |
The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy
- E Herrera-Carrillo
- & B Berkhout
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Original Article |
Sustained inhibition of hepatitis B virus replication in vivo using RNAi-activating lentiviruses
- D Ivacik
- , A Ely
- & P Arbuthnot
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Original Article |
Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection
- A Wagemakers
- , L M K Mason
- & J W R Hovius
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Original Article |
Neutralizing antibodies against AAV2, AAV5 and AAV8 in healthy and HIV-1-infected subjects in China: implications for gene therapy using AAV vectors
- Q Liu
- , W Huang
- & Y Wang
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Original Article |
Short noncoding DNA fragments improve the immune potency of electroporation-mediated HBV DNA vaccination
- J Peng
- , S Shi
- & Y Xu
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Original Article |
Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines
- A A Walters
- , E Kinnear
- & J S Tregoning
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Original Article |
Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter
- P Wang
- , X Qu
- & H Zhu
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Short Communication |
Efficient delivery of lentiviral vectors into resting human CD4 T cells
- X Geng
- , G Doitsh
- & W C Greene
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Original Article |
HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity
- W Huang
- , W Zheng
- & S Hao
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Original Article |
Gene transfer of integration defective anti-HSV-1 meganuclease to human corneas ex vivo
- H M Elbadawy
- , M Gailledrat
- & S Ferrari
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Mini Review |
Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART
- C W Peterson
- , P Younan
- & H-P Kiem
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Original Article |
Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination
- P Fagone
- , D J Shedlock
- & D B Weiner
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Original Article |
Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2
- M Zandian
- , K R Mott
- & H Ghiasi
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Enabling Technologies |
Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection
- C-S Hong
- , W Fellows
- & P Grandi
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Original Article |
Development of a nonintegrating Rev-dependent lentiviral vector carrying diphtheria toxin A chain and human TRAF6 to target HIV reservoirs
- Z Wang
- , Z Tang
- & Y Wu
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Original Article |
Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge
- T J Van Blarcom
- , C Sofer-Podesta
- & G Georgiou
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Original Article |
Generation of human TRIM5α mutants with high HIV-1 restriction activity
- Q T Pham
- , A Bouchard
- & L Berthoux
AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia
Cell-based gene therapy against HIV