Featured
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Brief Communication
| Open Access
Advancing rare disease treatment: EMA’s decade-long insights into engineered adoptive cell therapy for rare cancers and orphan designation
- Maria Elisabeth Kalland
- , Tomas Pose-Boirazian
- & Segundo Mariz
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Article
| Open Access
RapaCaspase-9-based suicide gene applied to the safety of IL-1RAP CAR-T cells
- Lucie Bouquet
- , Elodie Bôle-Richard
- & Marina Deschamps
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Brief Communication
| Open Access
Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
- Anna-Katharina Franke
- , Charlotte Wessolowski
- & Kerstin Cornils
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Article
| Open Access
Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation
- Emma Proics
- , Marion David
- & Céline Dumont
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Article |
Development of a cGMP-compliant process to manufacture donor-derived, CD45RA-depleted memory CD19-CAR T cells
- Young-In Kim-Hoehamer
- , Janice M. Riberdy
- & Sheng Zhou
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Article
| Open Access
Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients
- Lea Isabell Schwarze
- , Tanja Sonntag
- & Boris Fehse
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Article
| Open Access
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma
- Sabrina Prommersberger
- , Michael Reiser
- & Zoltán Ivics
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Review Article
| Open Access
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
- Nawid Albinger
- , Jessica Hartmann
- & Evelyn Ullrich
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Article
| Open Access
Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells
- Anna K. Dreismann
- , Michelle E. McClements
- & Robert E. MacLaren
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Comment
| Open Access
From macrophage biology to macrophage-based cellular immunotherapies
- Elvira Mass
- & Nico Lachmann
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Article
| Open Access
Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells
- Laura Mosti
- , Lukas M. Langner
- & Toni Cathomen
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Review Article |
Effects of oncolytic viruses and viral vectors on immunity in glioblastoma
- Penghao Liu
- , Yaning Wang
- & Yu Wang
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Brief Communication |
‘Mini’ U6 Pol III promoter exhibits nucleosome redundancy and supports multiplexed coupling of CRISPR/Cas9 effects
- Roland Preece
- , Christos Georgiadis
- & Waseem Qasim
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Article |
Transposon-mediated generation of CAR-T cells shows efficient anti B-cell leukemia response after ex vivo expansion
- Leonardo Chicaybam
- , Luiza Abdo
- & Martín Hernán Bonamino
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Article
| Open Access
Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy
- Anandaroop Mukhopadhyay
- , Jocelyn Wright
- & Robert H. Pierce
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Comment
| Open Access
Driving cars to the clinic for solid tumors
- Mauro Castellarin
- , Keisuke Watanabe
- & Avery D. Posey Jr.
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Comment
| Open AccessFludarabine and neurotoxicity in engineered T-cell therapy
- Kate L. Lowe
- , Crystal L. Mackall
- & Gwendolyn Binder
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Original Article
| Open Access
Adipose tissue: a new target for electroporation-enhanced DNA vaccines
- P D Fisher
- , C J Brambila
- & K E Broderick
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Original Article |
Primary T cells for mRNA-mediated immunotoxin delivery
- R Eggers
- , A Philippi
- & M J Schmitt
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Short Communication |
Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery
- C Goyvaerts
- , Y De Vlaeminck
- & K Breckpot
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Original Article |
Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation
- Y Sun
- , S Peng
- & C-F Hung
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Original Article
| Open Access
Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity
- K Mølgaard
- , M Compte
- & L Alvarez-Vallina
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Original Article
| Open Access
Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment
- E Eriksson
- , R Moreno
- & A Loskog
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Original Article |
Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction
- D Vavrincova-Yaghi
- , L E Deelman
- & M Sandovici
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Original Article |
A dual chain chimeric antigen receptor (CAR) in the native antibody format for targeting immune cells towards cancer cells without the need of an scFv
- E Faitschuk
- , V Nagy
- & H Abken
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Original Article |
Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies
- K Roellecke
- , E L Virts
- & H Hanenberg
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Original Article |
Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator
- M-C Chang
- , Y-L Chen
- & W-F Cheng
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Original Article |
Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression
- C Unzu
- , I Melero
- & A Fontanellas
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Original Article |
Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody
- G M Piperno
- , A López-Requena
- & M Cesco-Gaspere
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Original Article |
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules
- A B Rodriguez-Peña
- , J Gomez-Rodriguez
- & L Balagopalan
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Original Article
| Open Access
Lentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
- B S Sundarasetty
- , L Chan
- & R Stripecke
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Original Article |
B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity
- M-R Wu
- , T Zhang
- & C L Sentman
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Short Communication |
β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection
- M M El Khatib
- , T Sakuma
- & Y Ikeda
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Short Communication |
A new method to monitor antigen-specific CD8+ T cells, avoiding additional target cells and the restriction to human leukocyte antigen haplotype
- S Prommersberger
- , S Höfflin
- & J Dörrie
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Original Article |
γ134.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia
- G K Friedman
- , L Nan
- & G Y Gillespie
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Original Article |
Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: an in vitro proof-of-concept
- C Leboeuf
- , J Roser-Schilder
- & E Robinet
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Original Article |
DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
- T-Y Weng
- , M-C Yen
- & M-D Lai
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Original Article |
Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaque lower genital tract by AAV gene transfer
- U M Abdel-Motal
- , C Harbison
- & W A Marasco
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Original Article |
Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity
- K Watcharanurak
- , L Zang
- & Y Takakura
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Original Article |
Short noncoding DNA fragments improve the immune potency of electroporation-mediated HBV DNA vaccination
- J Peng
- , S Shi
- & Y Xu
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Original Article |
Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H
- Y Inaguma
- , Y Akahori
- & Y Akatsuka
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Original Article |
Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells
- J J Pen
- , B D Keersmaecker
- & K Breckpot
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Mini Review |
Immunotherapy with gene-modified T cells: limiting side effects provides new challenges
- H J Stauss
- & E C Morris
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Original Article |
Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma
- P C Schuberth
- , G Jakka
- & U Petrausch
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Original Article |
Therapeutic antitumor potential of endoglin-based DNA vaccine combined with immunomodulatory agents
- M Jarosz
- , J Jazowiecka-Rakus
- & S Szala
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Original Article
| Open Access
Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells
- C Goyvaerts
- , K De Groeve
- & K Breckpot
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Original Article |
Generating CTLs against the subdominant EBV LMP antigens by transient expression of an A20 inhibitor with EBV LMP proteins in human DCs
- B Hong
- , G Peng
- & X F Huang
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Original Article |
Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2
- M Zandian
- , K R Mott
- & H Ghiasi
Development of KoRV-pseudotyped lentiviral vectors for efficient gene transfer into freshly isolated immune cells