Brief Communication
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Open Access
Featured
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Patents |
Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials
Although the clinical application of induced pluripotent stem cells is still in its infancy, the development of iPSC technologies reflected by an increasing number of patents provides hope that they will realize their therapeutic potential.
- Liyang Lyu
- , Ye Feng
- & Yuanjia Hu
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Article |
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
AAV vectors form difficult-to-detect concatemers at Cas9 target sites.
- Fabian P. Suchy
- , Daiki Karigane
- & Hiromitsu Nakauchi
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Patents |
Biologic patent challenges under the America Invents Act
Administrative patent review procedures are an effective way of correcting erroneously granted biologic patents and may help promote timely drug competition for the benefit of patients and the US healthcare system.
- Victor L. Van de Wiele
- , Aaron S. Kesselheim
- & S. Sean Tu
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Article
| Open Access
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.
- Feng Ren
- , Alex Aliper
- & Alex Zhavoronkov
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Article
| Open Access
Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy
Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.
- C. L. Tan
- , K. Lindner
- & E. W. Green
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Career Feature |
SPARKing academic technologies across the valley of death
Stanford’s SPARK program has established a process that advances academic discoveries to industry partnerships or investigator-initiated clinical trials and provides training that enhances career opportunities for its graduates.
- Jeewon Sylvia Kim
- , Stephen Kargotich
- & Daria Mochly-Rosen
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Article |
An oncolytic virus–T cell chimera for cancer immunotherapy
Oncolytic adenovirus is delivered on T cells and engineered to express a checkpoint inhibitor.
- Yuxuan Chen
- , Xiaohong Chen
- & Yuan Ping
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Article
| Open Access
Activation of recombinases at specific DNA loci by zinc-finger domain insertions
Recombinases fused with zinc-finger domains are active only when bound to their DNA targets.
- Liliya Mukhametzyanova
- , Lukas Theo Schmitt
- & Frank Buchholz
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News & Views |
Wearable ultrasound for continuous deep-tissue monitoring
An integrated wearable and wireless ultrasound device enables the continuous monitoring of physiological information from tissues in moving individuals.
- Jon-Emile S. Kenny
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Perspective |
The challenges and promise of sweat sensing
A comprehensive look at wearable sweat sensors defines their capabilities.
- Noelle Davis
- , Jason Heikenfeld
- & Ali Javey
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Correspondence |
Cell and gene therapy approvals in Japan and the need for international harmonization
- Teruyo Arato
- & Kaori Nomura
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Research Briefing |
Metabolically enhanced CAR T cells efficiently clear solid tumors in mice
Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.
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Article |
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
CAR T cells engineered to express IL-10 eradicate solid tumors and metastases.
- Yang Zhao
- , Jiangqing Chen
- & Li Tang
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Patents |
The global patent landscape of artificial intelligence applications for cancer
A review of the emerging patent landscape can assist key actors in making informed strategic decisions about AI applications in oncology.
- Luiza Braga
- , Renato Lopes
- & Fabio Mota
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Article
| Open Access
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
β cells derived from stem cells improve blood glucose control in patients with diabetes.
- Bart Keymeulen
- , Kaat De Groot
- & Daniel Pipeleers
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News & Views |
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity.
- Kai Han
- , Young Seok Cho
- & James J. Moon
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Patents |
Do patent applications and Cooperative Research and Development Agreements between the National Cancer Institute and industry serve the public interest?
Policy changes are needed to ensure that Cooperative Research and Development Agreements and patent applications filed by the US National Institutes of Health are aligned with the interests of the American public.
- Austin Wesevich
- & Mark J. Ratain
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Career Feature |
ChatGPT and medicine: how AI language models are shaping the future and health related careers
ChatGPT holds transformative potential for medicine across clinical, research and educational domains.
- Michael Yan
- , Giovanni G. Cerri
- & Fabio Y. Moraes
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Article
| Open Access
Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration
Long-term expression of AAV transgenes in macaque liver is traced to integrated vectors.
- Jenny A. Greig
- , Kelly M. Martins
- & James M. Wilson
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Career Feature |
A strategy to incentivize innovation in the health care system: the innovation RVU
Encouraging innovation will allow physicians and their academic medical centers to pursue the development of technologies and healthcare practices that will improve patient care.
- Nathan V. Mallipeddi
- , Jay Chandra
- & Marc D. Succi
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News & Views |
A mucin degrader for cancer therapy
A new approach to targeting mucins via protein degradation shows promise against cancer.
- Richard Beatson
- & Joy M. Burchell
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Review Article |
Precision RNA base editing with engineered and endogenous effectors
Pfeiffer and Stafforst review and discuss the state-of-the-art tools for precision editing of RNA bases.
- Laura S. Pfeiffer
- & Thorsten Stafforst
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Article
| Open Access
Supervised discovery of interpretable gene programs from single-cell data
Spectra decomposes gene expression data into interpretable programs using prior knowledge.
- Russell Z. Kunes
- , Thomas Walle
- & Dana Pe’er
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Correspondence |
Scalable genomic data exchange and analytics with sBeacon
- Anuradha Wickramarachchi
- , Brendan Hosking
- & Denis C. Bauer
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Patents |
The global patent landscape of mRNA for diagnosis and therapy
The COVID-19 pandemic brought mRNA vaccines to market in a short period, pointing the entire drug development field in the direction of mRNA treatment.
- Mengru Lyu
- , Jiyuan Chen
- & Yuan Gao
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Patents |
The prevalence of drug patent term extensions in the United States, 2000–2018
Drug patents that are given patent term extension are important bellwether indicators for generic drug market entry.
- Victor L. Van de Wiele
- , Aaron S. Kesselheim
- & S. Sean Tu
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Career Feature |
The need for need-finding in medical education
The paradigm of developing a novel technology and applying it to a clinically relevant problem may be dominant in academic medicine, but more emphasis is needed in identifying important clinical problems before looking for solutions.
- Sainiteesh Maddineni
- & Wasan Kumar
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Research Briefing |
Detecting somatic mutations in single-cell data sets
We present an algorithm, SComatic, that can be used to directly detect somatic mutations in single-cell data sets without using a reference sample. This method opens the possibility of studying clonal relationships among cells, mutational processes at single-cell resolution, and the impact of somatic mutations on cell function in development and disease.
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Article
| Open Access
De novo detection of somatic mutations in high-throughput single-cell profiling data sets
SComatic identifies somatic mutations from scRNA-seq and scATAC data without a matched reference sample.
- Francesc Muyas
- , Carolin M. Sauer
- & Isidro Cortés-Ciriano
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Correspondence |
Defining a longevity biotechnology company
- Nicola Boekstein
- , Nir Barzilai
- & James Peyer
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Correspondence |
Democratizing knowledge representation with BioCypher
- Sebastian Lobentanzer
- , Patrick Aloy
- & Julio Saez-Rodriguez
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Career Feature |
What is hindering the drug development industry from achieving diversity, equity and inclusion in its workforce?
Establishing accountability by implementing measurable metrics to track and monitor DEI dynamics can ensure that it becomes central to an organization’s strategy.
- Jennifer Y. Kim
- & Emily Botto
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Patents |
The global patent landscape of HER2-targeted biologics
Global patents on HER2-targeted biologics show rapid growth and a diversified technology pattern.
- Qingjian Li
- , Jiaqi Xu
- & Herui Yao
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Article |
A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects
A wearable ultrasound patch monitors subjects in motion using machine learning and wireless electronics.
- Muyang Lin
- , Ziyang Zhang
- & Sheng Xu
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Research Briefing |
Selection by essential-gene exon knock-in for the generation of efficient cell therapies
By linking transgene expression with that of a housekeeping gene, SLEEK (selection by essential-gene exon knock-in) enables efficient knock-in of complex cargos in a variety of clinically relevant cell types. Using SLEEK, we were able to substantially improve the tumor suppression ability and in vivo persistence of a cell therapy.
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Article
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Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques
A genetic method to block immune rejection of allogeneic cells is validated in monkeys.
- Xiaomeng Hu
- , Kathy White
- & Sonja Schrepfer
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Research Briefing |
Sampling techniques and microbial concentration measurements influence the results of microbiome studies
Most microbiome studies measure relative abundance of the various microorganisms in a sample. This study demonstrates the feasibility of large-scale measurements of absolute microbial concentrations. Moreover, it demonstrates how sample handling and storage methods can alter microbial measurements, potentially introducing bias in conclusions drawn about microbiome–host relationships.
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Article
| Open Access
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice
Phage engineered with tail fibers and CRISPR–Cas reduce Escherichia coli load in animals.
- Yilmaz Emre Gencay
- , Džiuginta Jasinskytė
- & Morten Otto Alexander Sommer
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Article
| Open Access
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
An atlas of noncoding RNA in aging and rejuvenated mice identifies a set of deregulated miRNAs.
- Viktoria Wagner
- , Fabian Kern
- & Andreas Keller
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Article |
A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines
Automated fabrication of microneedle patch mRNA vaccines for COVID-19 may improve vaccine access.
- Aurélien vander Straeten
- , Morteza Sarmadi
- & Ana Jaklenec
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Career Feature |
Integrating a healthcare innovation bootcamp into an international medical conference to democratize innovation learning
Integration of an intensive innovation education bootcamp into a large international conference demonstrates statistically significant increases in participant understanding and knowledge of healthcare innovation.
- Marc D. Succi
- , Debby Cheng
- & James A. Brink
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Correspondence |
Challenges and solutions to advancing health equity with medical devices
- Kushal T. Kadakia
- , Vinay K. Rathi
- & Sanket S. Dhruva
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News & Views |
CRISPR editing in the lung with novel lipids
CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.
- Uri Elia
- , Edo Kon
- & Dan Peer
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Patents |
Distinguishing and predicting drug patents
Drug patents are different. To improve their quality ex ante, regulators can use predictive models.
- Colleen V. Chien
- , Nicholas Halkowski
- & Jeffrey Kuhn
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Article |
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
A single-cell screening approach identifies targets for CAR-T cells in acute myeloid leukemia.
- Adrian Gottschlich
- , Moritz Thomas
- & Sebastian Kobold
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Article
| Open Access
Deconvolution of clinical variance in CAR-T cell pharmacology and response
A model of T cell differentiation control deconvolutes biological mechanisms underlying clinical variance.
- Daniel C. Kirouac
- , Cole Zmurchok
- & Peter W. Zandstra
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Career Feature |
Retaining postdocs by recognizing their worth
Data from a postdoc salary and benefits survey may assist in retaining PhD holders interested in academia but considering alternate options owing to financial considerations.
- Esra Yalcin
- , Rosa Martinez-Corral
- & Mayank Chugh
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Article |
gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota
Taxon-specific primary metabolic pathways are identified using profile hidden Markov models.
- Victòria Pascal Andreu
- , Hannah E. Augustijn
- & Marnix H. Medema
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms