Health sciences

Definition

The health sciences study all aspects of health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

Latest Research and Reviews

  • Reviews |

    Recent microbiome genome-wide association studies have identified numerous associations between human genetic variants and the gut microbiome. Here, the authors review how genetic variation in the host can alter the composition of the gut microbiome towards a disease state, with a focus on disorders of immunity and metabolism.

    • Andrew Brantley Hall
    • , Andrew C. Tolonen
    •  & Ramnik J. Xavier
  • Research | | open

    The lectin receptor CLEC5A is a pattern recognition receptor that has been shown to detect dengue and Japanese encephalitis virus. Here the authors show that CLEC5A is needed for optimal ROS production, NET formation and other immune responses to Listeria monocytogenes in mice.

    • Szu-Ting Chen
    • , Fei-Ju Li
    • , Tzy-yun Hsu
    • , Shu-Mei Liang
    • , Yi-Chen Yeh
    • , Wen-Yu Liao
    • , Teh-Ying Chou
    • , Nien-Jun Chen
    • , Michael Hsiao
    • , Wen-Bin Yang
    •  & Shie-Liang Hsieh
  • Research | | open

    AP-1 family transcription factors regulate CD4+ T helper cell differentiation. Here the authors show that the AP-1 member JunB is a nonredundant regulator of transcriptional programs that support Th17 cell identity and restrain alternative Th1 and Treg cell fates in inflammatory contexts of acute fungal infection and chronic autoimmunity.

    • Tiffany M. Carr
    • , Joshua D. Wheaton
    • , Geoffrey M. Houtz
    •  & Maria Ciofani
  • Research | | open

    Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

    • Monika Haemmerle
    • , Morgan L. Taylor
    • , Tony Gutschner
    • , Sunila Pradeep
    • , Min Soon Cho
    • , Jianting Sheng
    • , Yasmin M. Lyons
    • , Archana S. Nagaraja
    • , Robert L. Dood
    • , Yunfei Wen
    • , Lingegowda S. Mangala
    • , Jean M. Hansen
    • , Rajesha Rupaimoole
    • , Kshipra M. Gharpure
    • , Cristian Rodriguez-Aguayo
    • , Sun Young Yim
    • , Ju-Seog Lee
    • , Cristina Ivan
    • , Wei Hu
    • , Gabriel Lopez-Berestein
    • , Stephen T. Wong
    • , Beth Y. Karlan
    • , Douglas A. Levine
    • , Jinsong Liu
    • , Vahid Afshar-Kharghan
    •  & Anil K. Sood
  • Research | | open

    Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.

    • Satish Ranjan
    • , Alexander Goihl
    • , Shrey Kohli
    • , Ihsan Gadi
    • , Mandy Pierau
    • , Khurrum Shahzad
    • , Dheerendra Gupta
    • , Fabian Bock
    • , Hongjie Wang
    • , Haroon Shaikh
    • , Thilo Kähne
    • , Dirk Reinhold
    • , Ute Bank
    • , Ana C. Zenclussen
    • , Jana Niemz
    • , Tina M. Schnöder
    • , Monika Brunner-Weinzierl
    • , Thomas Fischer
    • , Thomas Kalinski
    • , Burkhart Schraven
    • , Thomas Luft
    • , Jochen Huehn
    • , Michael Naumann
    • , Florian H. Heidel
    •  & Berend Isermann
  • Research | | open

    Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation in vivo.

    • Zaniar Ghazizadeh
    • , Der-I Kao
    • , Sadaf Amin
    • , Brandoch Cook
    • , Sahana Rao
    • , Ting Zhou
    • , Tuo Zhang
    • , Zhaoying Xiang
    • , Reyn Kenyon
    • , Omer Kaymakcalan
    • , Chengyang Liu
    • , Todd Evans
    •  & Shuibing Chen

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