Embryogenesis articles within Nature

Featured

  • Article |

    Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.

    • Xufeng Xue
    • , Yung Su Kim
    •  & Jianping Fu

  • Article
    | Open Access

    A genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis captures the codevelopment of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early haematopoiesis, with potential for drug testing and disease modelling.

    • Joshua Hislop
    • , Qi Song
    •  & Mo R. Ebrahimkhani

  • Article
    | Open Access

    Authentic hypoblast cells created from naive human pluripotent stem cells (hPSCs) spontaneously assemble with naive hPSCs to form a three-dimensional bilaminar structure (bilaminoids) with a pro-amniotic-like cavity.

    • Takumi Okubo
    • , Nicolas Rivron
    •  & Yasuhiro Takashima

  • Article
    | Open Access

    We present the ‘zebrafish single-cell atlas of perturbed embryos’, single-cell trancriptomic data of developing zebrafish embryos across various timepoints and with genetic perturbations.

    • Lauren M. Saunders
    • , Sanjay R. Srivatsan
    •  & Cole Trapnell

  • Article
    | Open Access

    The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up to 13–14 days after fertilization.

    • Bernardo Oldak
    • , Emilie Wildschutz
    •  & Jacob H. Hanna

  • Article
    | Open Access

    Co-culture of wild-type human embryonic stem cells with two types of extraembryonic-like cell engineered to overexpress specific transcription factors results in an embryoid model that recapitulates multiple features of the post-implantation human embryo.

    • Bailey A. T. Weatherbee
    • , Carlos W. Gantner
    •  & Magdalena Zernicka-Goetz

  • Article |

    Mass spectrometry and structural studies demonstrate the specific changes in protein composition that accompany the transition of ribosomes in zebrafish and Xenopus eggs from a dormant to an active state during early embryogenesis.

    • Friederike Leesch
    • , Laura Lorenzo-Orts
    •  & Andrea Pauli

  • Article |

    An in vitro system that recapitulates temporal characteristics of embryonic development demonstrates that the different rates of mouse and human embryonic development stem from differences in metabolic rates and—further downstream—the global rate of protein synthesis.

    • Margarete Diaz-Cuadros
    • , Teemu P. Miettinen
    •  & Olivier Pourquié

  • Article |

    A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.

    • Yoshihiro Yamanaka
    • , Sofiane Hamidi
    •  & Cantas Alev

  • Article
    | Open Access

    In-depth transcriptomic analyses of 56,636 single cells from monkey embryos revealed transcriptional features of major perigastrulation cell types, and comparative analyses with mouse embryos and human embryoids uncovered conserved and divergent features of perigastrulation development across species.

    • Jinglei Zhai
    • , Jing Guo
    •  & Hongmei Wang

  • Article
    | Open Access

    Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.

    • Gianluca Amadei
    • , Charlotte E. Handford
    •  & Magdalena Zernicka-Goetz

  • Article |

    3D transcriptomes reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.

    • Sophie Bergmann
    • , Christopher A. Penfold
    •  & Thorsten E. Boroviak

  • Article
    | Open Access

    Blastoids derived from naive PXGL-cultured human pluripotent stem cells in which Hippo, TGF-β and ERK pathways are inhibited closely recapitulate aspects of blastocyst development, form cells resembling blastocyst-stage cells and thus provide a model system for implantation and development studies.

    • Harunobu Kagawa
    • , Alok Javali
    •  & Nicolas Rivron

  • Article |

    The single-cell transcriptional profile of a human embryo between 16 and 19 days after fertilization reveals parallels and differences in gastrulation in humans as compared with mouse and non-human primate models.

    • Richard C. V. Tyser
    • , Elmir Mahammadov
    •  & Shankar Srinivas

  • Article |

    Fossiomanus sinensis and Jueconodon cheni, a newly described Early Cretaceous tritylodontid and eutriconodotan, respectively, show convergence on a fossorial body plan and provide insights into the evolution of the axial skeleton in mammaliamorphs.

    • Fangyuan Mao
    • , Chi Zhang
    •  & Jin Meng

  • Article |

    Phylogenies of human placental cells based on whole-genome sequencing of bulk samples and microdissections reveal extensive mutagenesis in placental tissue, and suggest that mosaicism is a typical part of normal placental development.

    • Tim H. H. Coorens
    • , Thomas R. W. Oliver
    •  & Sam Behjati

  • Article |

    Mechanical load-sharing enables the long-range cooperative uptake of apoptotic cells by multiple epithelial cells; and clearance of these apoptotic cells facilitates error correction, which is necessary for developmental robustness and survival of the embryo.

    • Esteban Hoijman
    • , Hanna-Maria Häkkinen
    •  & Verena Ruprecht

  • Article |

    Single-cell RNA-sequencing analysis of embryogenesis and X chromosome inactivation in the opossum (Monodelphis domestica) resolves the developmental trajectory of a marsupial, and sheds light on the evolution of embryogenesis in mammals.

    • Shantha K. Mahadevaiah
    • , Mahesh N. Sangrithi
    •  & James M. A. Turner

  • Article |

    Single-cell allelic HiC analysis, combined with allelic gene expression and chromatin states, reveals parent-of-origin-specific dynamics of chromosome organization and gene expression during mouse preimplantation development.

    • Samuel Collombet
    • , Noémie Ranisavljevic
    •  & Edith Heard

  • Article |

    Human presomitic mesoderm cells derived in vitro demonstrate oscillations of the segmentation clock, thus providing a window into an otherwise inaccessible stage of human development.

    • Margarete Diaz-Cuadros
    • , Daniel E. Wagner
    •  & Olivier Pourquié

  • Article |

    Single-cell mapping of chromatin accessibility, DNA methylation and RNA expression during gastrulation in mouse embryos shows characteristic epigenetic changes that accompany formation of the primary germ layers.

    • Ricard Argelaguet
    • , Stephen J. Clark
    •  & Wolf Reik

  • Article |

    Tissue shape changes in the posterior endoderm of the early Drosophila embryo are driven by actomyosin contractions emerging from a transcriptional induction followed by a mechanically-driven propagation of RhoI–myosin II activation.

    • Anaïs Bailles
    • , Claudio Collinet
    •  & Thomas Lecuit

  • Article |

    A multi-channel molecular recording technique is applied as a lineage tracer to assemble cell-fate maps from fertilization through gastrulation in the mouse, providing insights into ontogeny in a complex multicellular organism.

    • Michelle M. Chan
    • , Zachary D. Smith
    •  & Jonathan S. Weissman

  • Article |

    The developing mouse gut endoderm, mapped at single-cell resolution, reveals trajectories of cell differentiation before and during gastrulation and the emergence of regionalized cell identities along the anterior–posterior axis of the gut tube.

    • Sonja Nowotschin
    • , Manu Setty
    •  & Dana Pe’er

  • Letter |

    In the red flour beetle (Tribolium castaneum) and fruit fly (Drosophila melanogaster), spatiotemporally coordinated integrin-dependent attachments between the blastoderm and vitelline envelope counteract tissue-intrinsic contractile forces to create asymmetric movements of embryonic tissue.

    • Stefan Münster
    • , Akanksha Jain
    •  & Pavel Tomancak

  • Article |

    Data from single-cell combinatorial-indexing RNA-sequencing analysis of 2 million cells from mouse embryos between embryonic days 9.5 and 13.5 are compiled in a cell atlas of mouse organogenesis, which provides a global view of developmental processes occurring during this critical period.

    • Junyue Cao
    • , Malte Spielmann
    •  & Jay Shendure

  • Letter |

    Cell-labelling experiments are used to demonstrate that the hindgut in the chick embryo is formed by cells moving through the stationary caudal intestinal portal as a result of a contractile force gradient directed by fibroblast growth factor signalling.

    • Nandan L. Nerurkar
    • , ChangHee Lee
    •  & Clifford J. Tabin

  • Letter |

    Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.

    • Nicolas C. Rivron
    • , Javier Frias-Aldeguer
    •  & Niels Geijsen

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