Neurulation articles within Nature

Featured

• Article
  25 August 2022 | Open Access

  Embryo model completes gastrulation to neurulation and organogenesis

  Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.

  • Gianluca Amadei
  • , Charlotte E. Handford
  •  & Magdalena Zernicka-Goetz

• Letter | 03 February 2010

  CHD7 cooperates with PBAF to control multipotent neural crest formation

  Heterozygous mutations in the gene encoding CHD7, an ATP-dependent chromatin-remodelling protein, result in CHARGE syndrome — a disorder characterized by malformations of the craniofacial structures, peripheral nervous system, ears, eyes and heart. In humans and Xenopus, CHD7 is now shown to be essential for the formation of multipotent migratory neural crest and for activating the transcriptional circuitry of the neural crest; shedding light on the pathoembryology of CHARGE syndrome.

  • Ruchi Bajpai
  • , Denise A. Chen
  •  & Joanna Wysocka