Gastrulation articles within Nature

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  • Article
    | Open Access

    In zebrafish embryos, active complexes of Wnt5b and its membrane-bound receptor Ror2 are transported between cells via cellular protrusions called cytonemes to initiate paracrine Wnt5b signalling in cells that do not endogenously express the receptor.

    • Chengting Zhang
    • , Lucy Brunt
    •  & Steffen Scholpp

  • Article
    | Open Access

    Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.

    • Gianluca Amadei
    • , Charlotte E. Handford
    •  & Magdalena Zernicka-Goetz

  • Article |

    3D transcriptomes reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.

    • Sophie Bergmann
    • , Christopher A. Penfold
    •  & Thorsten E. Boroviak

  • Article |

    The single-cell transcriptional profile of a human embryo between 16 and 19 days after fertilization reveals parallels and differences in gastrulation in humans as compared with mouse and non-human primate models.

    • Richard C. V. Tyser
    • , Elmir Mahammadov
    •  & Shankar Srinivas

  • Article |

    Mechanical load-sharing enables the long-range cooperative uptake of apoptotic cells by multiple epithelial cells; and clearance of these apoptotic cells facilitates error correction, which is necessary for developmental robustness and survival of the embryo.

    • Esteban Hoijman
    • , Hanna-Maria Häkkinen
    •  & Verena Ruprecht

  • Article |

    Single-cell mapping of chromatin accessibility, DNA methylation and RNA expression during gastrulation in mouse embryos shows characteristic epigenetic changes that accompany formation of the primary germ layers.

    • Ricard Argelaguet
    • , Stephen J. Clark
    •  & Wolf Reik

  • Article |

    Tissue shape changes in the posterior endoderm of the early Drosophila embryo are driven by actomyosin contractions emerging from a transcriptional induction followed by a mechanically-driven propagation of RhoI–myosin II activation.

    • Anaïs Bailles
    • , Claudio Collinet
    •  & Thomas Lecuit

  • Letter |

    In the red flour beetle (Tribolium castaneum) and fruit fly (Drosophila melanogaster), spatiotemporally coordinated integrin-dependent attachments between the blastoderm and vitelline envelope counteract tissue-intrinsic contractile forces to create asymmetric movements of embryonic tissue.

    • Stefan Münster
    • , Akanksha Jain
    •  & Pavel Tomancak

  • Letter |

    Stimulation of Wnt and Nodal pathways in micropatterned human embryonic stem cell colonies induce these colonies to exhibit characteristic spatial expression patterns of the organizer and reproduce organizer function when grafted into a host embryo.

    • I. Martyn
    • , T. Y. Kanno
    •  & A. H. Brivanlou

  • Letter |

    Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynamic DNA methylation and demethylation is crucial to regulate key signalling pathways in early body plan formation.

    • Hai-Qiang Dai
    • , Bang-An Wang
    •  & Guo-Liang Xu

  • Article |

    Body axis elongation from head to tail is essential for animal development, however, the spatial cues that direct cell rearrangements relative to the anterior–posterior axis were unknown; this Drosophila study of convergent extension reveals that three Toll family receptors, expressed in overlapping stripes, modulate the contractile properties of cells to generate the polarized cell rearrangements that lead to body axis elongation.

    • Adam C. Paré
    • , Athea Vichas
    •  & Jennifer A. Zallen

  • Article |

    This study investigates how zygotic transcription is initiated and the maternal transcripts cleared in the zebrafish embryo: using loss-of-function analyses, high-throughput transcriptome sequencing and ribosome footprinting, the important roles of pluripotency factors Nanog, Pou5f1 and SoxB1 during these processes are identified.

    • Miler T. Lee
    • , Ashley R. Bonneau
    •  & Antonio J. Giraldez

  • Letter |

    Opaque tissues provide a challenge for live imaging of Xenopus laevis development; a problem solved by in vivo time-lapse X-ray microtomography that is shown to provide a high-resolution three-dimensional view of structural changes and dynamics of gastrulation, and that is applied to identify and analyse new aspects of gastrulation in frog embryos.

    • Julian Moosmann
    • , Alexey Ershov
    •  & Ralf Hofmann

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