Article
|
Open Access
Featured
-
-
Article |
Generation of specialized blood vessels via lymphatic transdifferentiation
A study of zebrafish identifies an innate mechanism of blood vessel formation through the transdifferentiation of lymphatic endothelial cells, and provides in vivo evidence for a link between cell ontogeny and functionality in endothelial cells.
- Rudra N. Das
- , Yaara Tevet
- & Karina Yaniv
-
Article |
Extensive phylogenies of human development inferred from somatic mutations
Somatic mutations obtained from laser microdissected biopsies of human tissues are used to reconstruct the developmental phylogenies of these tissues back to the zygote.
- Tim H. H. Coorens
- , Luiza Moore
- & Michael R. Stratton
-
Article |
Inherent mosaicism and extensive mutation of human placentas
Phylogenies of human placental cells based on whole-genome sequencing of bulk samples and microdissections reveal extensive mutagenesis in placental tissue, and suggest that mosaicism is a typical part of normal placental development.
- Tim H. H. Coorens
- , Thomas R. W. Oliver
- & Sam Behjati
-
Article |
Initiation of a conserved trophectoderm program in human, cow and mouse embryos
Comparative analysis of human, cow and mouse embryos shows that a mechanism involving atypical protein kinase C initiates the trophectoderm program during the morula stage in these three species.
- Claudia Gerri
- , Afshan McCarthy
- & Kathy K. Niakan
-
Article |
Keratins are asymmetrically inherited fate determinants in the mammalian embryo
Keratins are determinants of cell fate during mammalian embryogenesis, and are distributed asymmetrically between daughter cells during cell division.
- Hui Yi Grace Lim
- , Yanina D. Alvarez
- & Nicolas Plachta
-
Article |
A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation
Single-cell RNA-sequencing analysis of embryogenesis and X chromosome inactivation in the opossum (Monodelphis domestica) resolves the developmental trajectory of a marsupial, and sheds light on the evolution of embryogenesis in mammals.
- Shantha K. Mahadevaiah
- , Mahesh N. Sangrithi
- & James M. A. Turner
-
Article |
In vitro characterization of the human segmentation clock
Human presomitic mesoderm cells derived in vitro demonstrate oscillations of the segmentation clock, thus providing a window into an otherwise inaccessible stage of human development.
- Margarete Diaz-Cuadros
- , Daniel E. Wagner
- & Olivier Pourquié
-
Letter |
Reconstituting the transcriptome and DNA methylome landscapes of human implantation
Transcriptomics and DNA methylomics are used to study the implantation process of human embryos at single-cell resolution.
- Fan Zhou
- , Rui Wang
- & Fuchou Tang
-
Article |
Molecular recording of mammalian embryogenesis
A multi-channel molecular recording technique is applied as a lineage tracer to assemble cell-fate maps from fertilization through gastrulation in the mouse, providing insights into ontogeny in a complex multicellular organism.
- Michelle M. Chan
- , Zachary D. Smith
- & Jonathan S. Weissman
-
Article |
The emergent landscape of the mouse gut endoderm at single-cell resolution
The developing mouse gut endoderm, mapped at single-cell resolution, reveals trajectories of cell differentiation before and during gastrulation and the emergence of regionalized cell identities along the anterior–posterior axis of the gut tube.
- Sonja Nowotschin
- , Manu Setty
- & Dana Pe’er
-
Article |
The single-cell transcriptional landscape of mammalian organogenesis
Data from single-cell combinatorial-indexing RNA-sequencing analysis of 2 million cells from mouse embryos between embryonic days 9.5 and 13.5 are compiled in a cell atlas of mouse organogenesis, which provides a global view of developmental processes occurring during this critical period.
- Junyue Cao
- , Malte Spielmann
- & Jay Shendure
-
Article |
Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration
Reversion of adult skeletal stem cells to a developmental state underlies the growth of new bone during jaw regeneration, in a process that relies on mechanotransduction via the focal adhesion kinase protein.
- Ryan C. Ransom
- , Ava C. Carter
- & Michael T. Longaker
-
Article |
Erythro-myeloid progenitors contribute endothelial cells to blood vessels
New blood vessel endothelial cells arise from differentiation of erythro-myeloid progenitor cells to complement the proliferation of pre-existing endothelial cells.
- Alice Plein
- , Alessandro Fantin
- & Christiana Ruhrberg
-
Letter |
Blastocyst-like structures generated solely from stem cells
Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.
- Nicolas C. Rivron
- , Javier Frias-Aldeguer
- & Niels Geijsen
-
Letter |
The cis-regulatory dynamics of embryonic development at single-cell resolution
An improved assay for chromatin accessibility at single-cell resolution in Drosophila melanogaster embryos enables identification of developmental-stage- and cell-lineage-specific patterns of chromatin-level transcriptional regulation.
- Darren A. Cusanovich
- , James P. Reddington
- & Eileen E. M. Furlong
-
Letter |
Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus
Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.
- Ming Jiang
- , Haiyan Li
- & Jianwen Que
-
Article |
Genome editing reveals a role for OCT4 in human embryogenesis
Genome editing in human zygotes shows that OCT4 is required for normal development at an earlier stage in humans than in mice.
- Norah M. E. Fogarty
- , Afshan McCarthy
- & Kathy K. Niakan
-
Article |
Tracing haematopoietic stem cell formation at single-cell resolution
Successful identification of mouse embryonic pre-haematopoietic stem cells at single-cell resolution.
- Fan Zhou
- , Xianlong Li
- & Bing Liu
-
Letter |
A relative shift in cloacal location repositions external genitalia in amniote evolution
It has been known for some time that limbs share at least some of their molecular patterning mechanism with external genitalia; here, this connection is examined in a variety of species, revealing that once-shared developmental trajectories could help to explain the observed patterning similarities.
- Patrick Tschopp
- , Emma Sherratt
- & Clifford J. Tabin
-
Letter |
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
A population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart expresses Wnt2, Gli1 and Isl1; these CPPs arise from cardiac progenitors before lung development, generate the mesoderm lineages within the cardiac inflow tract and lung, and are regulated by hedgehog expression from the foregut endoderm.
- Tien Peng
- , Ying Tian
- & Edward E. Morrisey
-
-
Brief Communications Arising |
Location of corneal epithelial stem cells
- Tung-Tien Sun
- , Scheffer C. Tseng
- & Robert M. Lavker
A median fin derived from the lateral plate mesoderm and the origin of paired fins