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| Open AccessComparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
- Verena Aumiller
- , Benjamin Strobel
- & Sebastian Kreuz
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| Open AccessAntimicrobial peptide cWFW kills by combining lipid phase separation with autolysis
- Kathi Scheinpflug
- , Michaela Wenzel
- & Henrik Strahl
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| Open Access(+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors
- Gui-yang Xia
- , De-juan Sun
- & Feng Qiu
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| Open AccessDesign and Functional Characterization of a Novel Abscisic Acid Analog
- Xiaoqiang Han
- , Lun Jiang
- & Zhaohai Qin
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| Open AccessA network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases
- Hai-Yang Fang
- , Hua-Wu Zeng
- & Jing Zhao
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| Open AccessENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes
- Haaglim Cho
- , JungIn Um
- & Darren R. Williams
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| Open AccessBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides
- Cyrille Mathieu
- , Marcelo T. Augusto
- & Anne Moscona
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| Open AccessNeoagaro-oligosaccharide monomers inhibit inflammation in LPS-stimulated macrophages through suppression of MAPK and NF-κB pathways
- Wei Wang
- , Pei Liu
- & Xiangzhao Mao
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Article
| Open AccessAnordrin Eliminates Tamoxifen Side Effects without Changing Its Antitumor Activity
- Wenwen Gu
- , Wenping Xu
- & Jun Yang
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| Open AccessScreening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons
- Yousuf O. Ali
- , Gillian Bradley
- & Hui-Chen Lu
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| Open AccessProtectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype
- Haifa Xia
- , Lin Chen
- & Shanglong Yao
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| Open AccessA Bayesian Target Predictor Method based on Molecular Pairing Energies estimation
- Antoni Oliver
- , Vincent Canals
- & Josep L. Rosselló
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| Open AccessA selective and label-free strategy for rapid screening of telomere-binding Ligands via fluorescence regulation of DNA/silver nanocluster
- Rui Cheng
- , Jing Xu
- & Yan Jin
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| Open AccessAndrogen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11
- Yunfei Liao
- , Slim Sassi
- & Zhenfeng Duan
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| Open AccessTheranostic 3-Dimensional nano brain-implant for prolonged and localized treatment of recurrent glioma
- Ranjith Ramachandran
- , Vijayabhaskar Reddy Junnuthula
- & Manzoor Koyakutty
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| Open AccessGlucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential
- Ebony R. Fietz
- , Christine R. Keenan
- & Alastair G. Stewart
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| Open AccessChemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways
- Xin-Hua Liao
- , Arina Li Zhang
- & Kun Ping Lu
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| Open AccessSwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
- Antoine Daina
- , Olivier Michielin
- & Vincent Zoete
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| Open AccessTranscriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells
- Daniel F. Hicks
- , Nicolas Goossens
- & Scott L. Friedman
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| Open AccessProtein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding
- Renjie Huang
- , Arnaud Bonnichon
- & Ivanhoe K. H. Leung
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Article
| Open AccessGrape seed proanthocyanidins prevent irradiation-induced differentiation of human lung fibroblasts by ameliorating mitochondrial dysfunction
- XiaoHong Yang
- , Tao Liu
- & XiaoHong Chen
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| Open AccessMagnetic nanoparticles: a strategy to target the choroidal layer in the posterior segment of the eye
- Martina Giannaccini
- , Lucia Pedicini
- & Vittoria Raffa
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| Open AccessRescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs
- Conor M. Ramsden
- , Britta Nommiste
- & Peter J. Coffey
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| Open AccessA novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
- Ilze Bot
- , Natalia V. Ortiz Zacarías
- & Laura H. Heitman
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| Open AccessSalvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin
- Yunxia Liu
- , Yingying Hu
- & Wen Liu
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| Open AccessInsights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C
- Dibya Ghimire
- , Uddhav Timilsina
- & Ritu Gaur
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| Open AccessA pharmacological approach in newly established retinal vein occlusion model
- Shinichiro Fuma
- , Anri Nishinaka
- & Hideaki Hara
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| Open AccessTRPA1 mediated aggravation of allergic contact dermatitis induced by DINP and regulated by NF-κB activation
- Jun Kang
- , Yong Ding
- & Mingqing Chen
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| Open AccessDiscovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site
- Xin Zhai
- , Xiaoqiang Wang
- & Ping Gong
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| Open AccessHyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists
- Simona De Marino
- , Adriana Carino
- & Angela Zampella
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Article
| Open AccessPentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis
- Chun-Lin Chen
- , Pei-Hua Yang
- & Shih-Wei Wang
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| Open AccessCombination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity
- Robert H. Berndsen
- , Andrea Weiss
- & Patrycja Nowak-Sliwinska
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| Open AccessAnticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction
- Chao Yang
- , Wanhe Wang
- & Chung-Hang Leung
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| Open AccessNovel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations
- Liying Zhang
- , Chengjun Song
- & Youde Wang
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| Open AccessIntracellular drug bioavailability: a new predictor of system dependent drug disposition
- André Mateus
- , Andrea Treyer
- & Per Artursson
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| Open AccessScale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats
- Mozhgan Raigani
- , Mohammad-Reza Rouini
- & Fereidoun Mahboudi
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| Open AccessStellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities
- Myungsuk Kim
- , Hee Ju Lee
- & Chu Won Nho
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| Open AccessHuman enterovirus 71 protein interaction network prompts antiviral drug repositioning
- Lu Han
- , Kang Li
- & Shengqi Wang
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| Open AccessFlucrypyrim, a novel uterine relaxant, has antinociceptive and anti-inflammatory effects in vivo
- Zhongtang Li
- , Limei Wang
- & Yuwen Cong
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| Open AccessHyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment
- Makoto Ohtake
- , Masanari Umemura
- & Yoshihiro Ishikawa
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| Open AccessMangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome
- Ramakrishna K. Bulugonda
- , Kotha Anil kumar
- & Syed M. Faisal
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| Open AccessSuramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A
- Peijun Ren
- , Yimei Zheng
- & Ralf Altmeyer
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| Open AccessTransient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice
- Emmanuel Dotsey
- , Irina Ushach
- & Philip L. Felgner
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| Open AccessIdentification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells
- David Estoppey
- , Jeffrey W. Hewett
- & Dominic Hoepfner
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| Open AccessThe small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms
- Tibor Kovács
- , Viktor Billes
- & Tibor Vellai
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| Open AccessA screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties
- Mohamad A. Zaini
- , Christine Müller
- & Cornelis F. Calkhoven
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| Open AccessJerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)
- Felicia Fei-Lei Chung
- , Perry Faith Tze Ming Tan
- & Chee-Onn Leong
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| Open AccesspH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance
- Wei Hong
- , Hong Shi
- & Li Kang
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| Open AccessPeptoids successfully inhibit the growth of gram negative E. coli causing substantial membrane damage
- Biljana Mojsoska
- , Gustavo Carretero
- & Håvard Jenssen