Drug discovery

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

Featured

News and Views | 27 August 2020

Neurological soft signs predict outcomes in schizophrenia
- Johannes Schröder
- & Pablo Toro
Nature Reviews Neurology, 1-2
News and Views | 17 August 2020

Linking volume and intensity of physical activity to mortality
- Jason M. R. Gill
Nature Medicine 26, 1332-1334
News and Views | 17 August 2020

Overcoming epigenetic roadblocks
- Maximilian W. D. Raas
- , Dick W. Zijlmans
- & Hendrik Marks
Nature Chemical Biology, 1-2

Latest Research and Reviews

Reviews
10 September 2020 | Open Access

Live biotherapeutic products: the importance of a defined regulatory framework
- Magali Cordaillat-Simmons
- , Alice Rouanet
- & Bruno Pot
Experimental & Molecular Medicine, 1-10
Research
09 September 2020 | Open Access

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers
- Heloisa Westphalen
- , Shaghayegh Saadati
- , Ubong Eduok
- , Amira Abdelrasoul
- , Ahmed Shoker
- , Phillip Choi
- , Huu Doan
- & Farhad Ein-Mozaffari
Scientific Reports 10, 14808
Research | 09 September 2020

Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer
- Nuwan Dharmawardana
- , Thomas Goddard
- , Charmaine Woods
- , David I. Watson
- , Eng H. Ooi
- & Roger Yazbeck
British Journal of Cancer, 1-7
Research
09 September 2020 | Open Access

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance functional recovery.
- Kun Xi
- , Yong Gu
- , Jincheng Tang
- , Hao Chen
- , Yun Xu
- , Liang Wu
- , Feng Cai
- , Lianfu Deng
- , Huilin Yang
- , Qin Shi
- , Wenguo Cui
- & Liang Chen
Nature Communications 11, 4504
Reviews
09 September 2020 | Open Access

Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review
- Aisha Islam
- , Lisa Alcock
- , Kianoush Nazarpour
- , Lynn Rochester
- & Annette Pantall
npj Parkinson's Disease 6, 22
Research
09 September 2020 | Open Access

An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability
- Atsushi Irie
- , Kazuki Sato
- , Rintaro Iwata Hara
- , Takeshi Wada
- & Futoshi Shibasaki
Scientific Reports 10, 14845