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| Open AccessA high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
- Anthony D. Verderosa
- , Rabeb Dhouib
- & Makrina Totsika
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| Open AccessPotential repurposing of four FDA approved compounds with antiplasmodial activity identified through proteome scale computational drug discovery and in vitro assay
- Bakary N’tji Diallo
- , Tarryn Swart
- & Kevin Lobb
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| Open AccessHigh-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
- Maxwell A. Stefan
- , Glory M. Velazquez
- & George A. Garcia
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| Open AccessSynthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents
- Lucas N. Solano
- , Grady L. Nelson
- & Venkatram R. Mereddy
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| Open AccessExploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway
- Xiaoyi Zhang
- , Jinhuan Zhang
- & Shiqi Peng
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| Open AccessA membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent
- Xiyuan Yao
- , Noah H. Watkins
- & Ulrich Bierbach
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| Open AccessHighly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
- M.Ángeles Bonache
- , Cristina Martín-Escura
- & Rosario González-Muñiz
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| Open AccessEpigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome
- David Reiner
- , Ludwig Seifert
- & Holger Stark
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| Open AccessPolyethylene glycol (5,000) succinate conjugate of lopinavir and its associated toxicity using Danio rerio as a model organism
- Oluwole Samuel Aremu
- , Lebogang Katata-Seru
- & Victor Wepener
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| Open AccessA strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies
- Tomasz Laskowski
- , Witold Andrałojć
- & Zofia Gdaniec
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| Open AccessHAPPENN is a novel tool for hemolytic activity prediction for therapeutic peptides which employs neural networks
- Patrick Brendan Timmons
- & Chandralal M. Hewage
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| Open AccessOptimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2
- Brandon Baer
- , Edwin J. A. Veldhuizen
- & Ruud Veldhuizen
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| Open AccessCaffeoyl–Pro–His amide relieve DNCB-Induced Atopic Dermatitis-Like phenotypes in BALB/c mice
- Sunhyae Jang
- , Jungyoon Ohn
- & Kyu Han Kim
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| Open AccessComputer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae
- Shasank S. Swain
- , Sudhir K. Paidesetty
- & Rabindra N. Padhy
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| Open AccessSynthesis, cytotoxicity, pharmacokinetic profile, binding with DNA and BSA of new imidazo[1,2-a]pyrazine-benzo[d]imidazol-5-yl hybrids
- Iqubal Singh
- , Vijay Luxami
- & Kamaldeep Paul
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| Open AccessSynthesis, biological activity and molecular modeling study of novel 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazines and 1,2,4-triazolo[4,3-b][1,2,4]triazines
- Ahmed A. M. El-Reedy
- & N. K. Soliman
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| Open AccessIsolation of two rare N-glycosides from Ginkgo biloba and their anti-inflammatory activities
- Jin-Tang Cheng
- , Cong Guo
- & An Liu
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| Open AccessAryl-alkyl-lysines: Novel agents for treatment of C. difficile infection
- Chandradhish Ghosh
- , Ahmed AbdelKhalek
- & Jayanta Haldar
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| Open AccessImproving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A
- Thiago R. Morais
- , Geanne A. Alves Conserva
- & João Henrique G. Lago
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| Open AccessDevelopment of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines
- Kyu Kwang Kim
- , Rakesh K. Singh
- & Richard G. Moore
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| Open AccessT-13 and T-26, the novel taxanes with improved oral bioavailability in rats
- Yun-Rong Jing
- , Wei Zhou
- & Xiang-Yang Wang
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| Open AccessRational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
- Julien Lalut
- , Hugo Payan
- & Christophe Rochais
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| Open AccessDesign and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins
- Fatema Hersi
- , Hany A. Omar
- & Taleb H. Al-Tel
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| Open AccessNovel and selective inactivators of Triosephosphate isomerase with anti-trematode activity
- Florencia Ferraro
- , Ileana Corvo
- & Guzmán Álvarez
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| Open AccessCellular apoptosis and necrosis as therapeutic targets for novel Eugenol Tosylate Congeners against Candida albicans
- Shabir Ahmad Lone
- , Mohmmad Younus Wani
- & Aijaz Ahmad
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| Open AccessA facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water
- Hong-Ju Byeon
- , Kyung-Hwan Jung
- & Hyang-Yeol Lee
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| Open AccessSynthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas
- Rajendran Senthilkumar
- , Yury Brusentsev
- & John Elias Eriksson
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| Open Access4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth
- Subhankar Panda
- , Nirmalya Pradhan
- & Debasis Manna
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| Open AccessA new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase
- Gilda Giancotti
- , Ilaria Rigo
- & Marcella Bassetto
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| Open AccessCharacterization and evaluation of mycosterol secreted from endophytic strain of Gymnema sylvestre for inhibition of α-glucosidase activity
- Amit Ranjan
- , Rajesh Kumar Singh
- & Santosh Kumar Singh
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| Open AccessExploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential
- Joanna Stalinska
- , Lisa Houser
- & Branko S. Jursic
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| Open AccessD-sorbitol can keep the viscosity of dispersive ophthalmic viscosurgical device at room temperature for long term
- Eiji Nogami
- , Ippei Watanabe
- & Kiyoshi Suzuki
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| Open AccessNew diphenylphosphane derivatives of ketoconazole are promising antifungal agents
- Rodrigo F. M. de Almeida
- , Filipa C. Santos
- & Radosław Starosta
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| Open AccessGram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles
- Jordan Chamberlin
- , Sandra Story
- & Dev P. Arya
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| Open AccessDesign, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes
- Myeong A Choi
- , Sun You Park
- & Young Ho Seo
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| Open Access18F-labelled triazolyl-linked argininamides targeting the neuropeptide Y Y1R for PET imaging of mammary carcinoma
- Simone Maschauer
- , Julian J. Ott
- & Olaf Prante
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| Open AccessSystemically Administered Plant Recombinant Holo-Intrinsic Factor Targets the Liver and is not Affected by Endogenous B12 levels
- Jayme L. Workinger
- , Akhila N. W. Kuda-Wedagedara
- & Robert P. Doyle
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| Open AccessAntiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
- Jang-Gi Choi
- , Young Soo Kim
- & Hwan-Suck Chung
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| Open AccessStudies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers
- Fazila Rizvi
- , Majid Khan
- & M. Iqbal Choudhary
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| Open AccessA semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division
- Maiara Amaral
- , Fernanda S. de Sousa
- & Andre G. Tempone
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| Open AccessChiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists
- Lina Sabatino
- , Pamela Ziccardi
- & Antonio Lavecchia
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| Open AccessDifferent substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
- Frank J. P. Kühn
- , Joanna M. Watt
- & Andreas Lückhoff
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| Open AccessAnti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation
- Quentin Spillier
- , Didier Vertommen
- & Raphaël Frédérick
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| Open AccessDiscovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1
- Francesco Saverio Di Leva
- , Carmen Festa
- & Vittorio Limongelli
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| Open AccessAplysinopsin-type and Bromotyrosine-derived Alkaloids from the South China Sea Sponge Fascaplysinopsis reticulata
- Qi Wang
- , Xu-Li Tang
- & Guo-Qiang Li
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| Open AccessMD001, a Novel Peroxisome Proliferator-activated Receptor α/γ Agonist, Improves Glucose and Lipid Metabolism
- Seok-Ho Kim
- , Shin Hee Hong
- & Sang Gyu Park
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| Open AccessCytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis
- Nursyamirah Abd Razak
- , Nadiah Abu
- & Swee Keong Yeap
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| Open AccessCationic Amphipathic Triazines with Potent Anti-bacterial, Anti-inflammatory and Anti-atopic Dermatitis Properties
- Pethaiah Gunasekaran
- , Ganesan Rajasekaran
- & Jeong Kyu Bang
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| Open AccessNovel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
- Florent Cochet
- , Fabio A. Facchini
- & Francesco Peri