Development of the nervous system articles within Nature

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  • Article
    | Open Access

    A study describes chromatin accessibility and paired gene expression across the entire developing human brain during the first trimester in the context of gene regulation and neurodevelopmental disease.

    • Camiel C. A. Mannens
    • , Lijuan Hu
    •  & Sten Linnarsson

  • Article
    | Open Access

    Antisense oligonucleotides effectively decrease the inclusion of exon  8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons.

    • Xiaoyu Chen
    • , Fikri Birey
    •  & Sergiu P. Pașca

  • Article
    | Open Access

    BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.

    • Xiaoyin Chen
    • , Stephan Fischer
    •  & Anthony M. Zador

  • Article |

    Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.

    • Xufeng Xue
    • , Yung Su Kim
    •  & Jianping Fu

  • Article
    | Open Access

    Latrophilin-3 organizes synapses through a convergent dual-pathway mechanism in which Gαs signalling is activated and phase-separated postsynaptic protein scaffolds are recruited.

    • Shuai Wang
    • , Chelsea DeLeon
    •  & Thomas C. Südhof

  • Article
    | Open Access

    A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.

    • Marcos Assis Nascimento
    • , Sean Biagiotti
    •  & Shawn F. Sorrells

  • Article
    | Open Access

    Single-nucleus RNA-sequencing data from the cerebellum of human, mouse and opossum is used to analyse the developmental dynamics of cell types and states in mammalian cerebellum and provide evolutionary insights.

    • Mari Sepp
    • , Kevin Leiss
    •  & Henrik Kaessmann

  • Article
    | Open Access

    Assembloids are integrated with CRISPR screening to investigate the involvement of 425 neurodevelopmental disorder genes in human interneuron development, showing endoplasmic reticulum displacement before nuclear translocation and interference from LNPK deletion, resulting in abnormal migration.

    • Xiangling Meng
    • , David Yao
    •  & Sergiu P. Pașca

  • Article
    | Open Access

    We develop a high-throughput CRISPR screening system in cerebral organoids and identify vulnerable cell types and gene regulatory networks associated with autism spectrum disorder from single-cell transcriptomes and chromatin modalities.

    • Chong Li
    • , Jonas Simon Fleck
    •  & Juergen A. Knoblich

  • Article |

    Experiments in zebrafish and human tissues show that, during retinal morphogenesis, emerging photoreceptor cells migrate in a bidirectional manner, which lessens competition for space and helps to ensure that the retina is formed correctly.

    • Mauricio Rocha-Martins
    • , Elisa Nerli
    •  & Caren Norden

  • Article |

    Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive function, indicating that the ENS is governed by a dedicated population of resident macrophages that adapt to the timely needs of the ENS.

    • Maria Francesca Viola
    • , Marta Chavero-Pieres
    •  & Guy Boeckxstaens

  • Article |

    A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.

    • Nicole Scholz
    • , Anne-Kristin Dahse
    •  & Tobias Langenhan

  • Article
    | Open Access

    A study maps neuronal genomic targets of oestrogen receptor-α and shows how they coordinate brain sexual differentiation, concluding that the genome remains responsive to hormonal changes after structural dimorphisms have been established.

    • B. Gegenhuber
    • , M. V. Wu
    •  & J. Tollkuhn

  • Article
    | Open Access

    MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

    • R. A. I. Bethlehem
    • , J. Seidlitz
    •  & A. F. Alexander-Bloch

  • Article
    | Open Access

    Evolutionary modelling shows that an initial set of inhibitory neurons serving olfactory bulbs may have been repurposed to diversify the taxonomy of interneurons found in the expanded striata and cortices in primates.

    • Matthew T. Schmitz
    • , Kadellyn Sandoval
    •  & Alex A. Pollen

  • Article |

    Studies in mice, humans and macaques show that retinoic acid signalling has an important role in the development of the prefrontal cortex (PFC) in primates and may also underlie the evolutionary diversification of the PFC.

    • Mikihito Shibata
    • , Kartik Pattabiraman
    •  & Nenad Sestan

  • Article |

    The transcriptional programs and chromatin accessibility changes that cause two related interneuronal subtypes to diverge from common developmental origins and acquire specialized properties are elucidated.

    • Kathryn C. Allaway
    • , Mariano I. Gabitto
    •  & Gord Fishell

  • Article |

    Serial-section electron microscopy is used to reconstruct the full brain connectome of eight individual Caenorhabditis elegans at various stages of development, providing insight into the principles underlying brain maturation.

    • Daniel Witvliet
    • , Ben Mulcahy
    •  & Mei Zhen

  • Article |

    A comprehensive single-cell transcriptomic atlas of the mouse brain between gastrulation and birth identifies hundreds of cellular states and reveals the spatiotemporal organization of brain development.

    • Gioele La Manno
    • , Kimberly Siletti
    •  & Sten Linnarsson

  • Article |

    The duration of a critical period of plasticity in the developing Drosophila motor circuit, during which motor neurons display activity-dependent refinement of neurite structure and connectivity, is dependent on astrocyte to motor neuron Neuroligin–Neurexin signalling.

    • Sarah D. Ackerman
    • , Nelson A. Perez-Catalan
    •  & Chris Q. Doe

  • Article |

    Two complete volumetric reconstructions of the Caenorhabditis elegans main neuropil (the nerve ring) reveal multi-scale spatial organization that supports both conserved and variable circuitry, and enables the derivation of a modular structure–function model of the neuropil.

    • Christopher A. Brittin
    • , Steven J. Cook
    •  & Netta Cohen

  • Article |

    A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

    • Tetsuya Takano
    • , John T. Wallace
    •  & Scott H. Soderling

  • Article |

    The neuronal diversity of the Drosophila optic lobe is described throughout pupal development by single-cell sequencing, leading to the discovery of transient extrinsic neurons and a dorsoventral asymmetry of the visual circuits.

    • Mehmet Neset Özel
    • , Félix Simon
    •  & Claude Desplan

  • Article |

    Analysis of cis-regulatory chromatin interactions, open chromatin and transcriptomes for different cell types isolated from mid-gestational human cortex samples provides insights into gene regulation during development.

    • Michael Song
    • , Mark-Phillip Pebworth
    •  & Yin Shen

  • Article |

    Single-cell RNA sequencing reveals molecular determinants of the developmental programs that orchestrate the intermingling of neuronal subtypes in the hypothalamus.

    • Roman A. Romanov
    • , Evgenii O. Tretiakov
    •  & Tibor Harkany

  • Article |

    Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.

    • Suijuan Zhong
    • , Wenyu Ding
    •  & Xiaoqun Wang

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