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Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.
- Nicole Scholz
- , Anne-Kristin Dahse
- & Tobias Langenhan
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Article
| Open AccessSingle-cell epigenomics reveals mechanisms of human cortical development
Analysis of chromatin state at a single-cell level in samples of developing human forebrain demonstrate both cell-type-specific and region-specific changes during neurogenesis.
- Ryan S. Ziffra
- , Chang N. Kim
- & Tomasz J. Nowakowski
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Article |
A multi-scale brain map derived from whole-brain volumetric reconstructions
Two complete volumetric reconstructions of the Caenorhabditis elegans main neuropil (the nerve ring) reveal multi-scale spatial organization that supports both conserved and variable circuitry, and enables the derivation of a modular structure–function model of the neuropil.
- Christopher A. Brittin
- , Steven J. Cook
- & Netta Cohen
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Letter |
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
Single-cell RNA-sequencing analysis demonstrates that individual human brain organoids generate the cellular diversity of the cerebral cortex with organoid-to-organoid variability that is comparable to that of individual endogenous brains.
- Silvia Velasco
- , Amanda J. Kedaigle
- & Paola Arlotta
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Article |
Integration of temporal and spatial patterning generates neural diversity
Combinatorial inputs from temporal and spatial axes act together to promote medullary neural diversity in the optic lobes of Drosophila.
- Ted Erclik
- , Xin Li
- & Claude Desplan
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Article |
A comprehensive transcriptional map of primate brain development
A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.
- Trygve E. Bakken
- , Jeremy A. Miller
- & Ed S. Lein
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Transcriptional landscape of the prenatal human brain
A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.
- Jeremy A. Miller
- , Song-Lin Ding
- & Ed S. Lein
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Books & Arts |
Neuroscience: Patterns from the brain
Vincent A. Billock recommends an introduction to the mathematics of geometric hallucinations.
- Vincent A. Billock
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News |
Why some memories stick
Repetitive neural responses may enhance recall of faces and words.
- Janelle Weaver
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Authors |
Abstractions