Featured
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Article |
Molecular architecture of the developing mouse brain
A comprehensive single-cell transcriptomic atlas of the mouse brain between gastrulation and birth identifies hundreds of cellular states and reveals the spatiotemporal organization of brain development.
- Gioele La Manno
- , Kimberly Siletti
- & Sten Linnarsson
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Article |
Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis
Astrocyte morphogenesis depends on interactions between astrocytic neuroligins and neuronal neurexins.
- Jeff A. Stogsdill
- , Juan Ramirez
- & Cagla Eroglu
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Article |
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity
Populations of astrocytes in the spinal cord are shown to express region-specific genes, with ventral astrocyte-encoded Sema3a necessary for proper motor neuron circuit organization and typical sensory afferent projection patterns; these findings suggest that astrocytes provide a positional cue for maintaining proper circuit formation and refinement.
- Anna V. Molofsky
- , Kevin W. Kelley
- & David H. Rowitch
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Research Highlights |
Glia for fast motor control
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Letter |
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
After myelination, oligodendrocytes are able to survive without mitochondrial respiration, suggesting that they can switch to aerobic glycolysis and release lactate.
- Ursula Fünfschilling
- , Lotti M. Supplie
- & Klaus-Armin Nave
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Letter |
A role for glia in the progression of Rett’s syndrome
- Daniel T. Lioy
- , Saurabh K. Garg
- & Gail Mandel
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News Feature |
Neuroscience: Settling the great glia debate
Do the billions of non-neuronal cells in the brain send messages of their own?
- Kerri Smith
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Article |
Neurogenic radial glia in the outer subventricular zone of human neocortex
In the mammalian brain, the subventricular zone (SVZ) produces neural progenitor cells that migrate into the cortex to populate the upper layers. In humans this region is massively expanded, producing an outer SVZ (OSVZ). Here, live-cell imaging of developing human tissue was used to show that the OSVZ has similar characteristics to the SVZ, with progenitor cells proliferating in a way that depends on the Notch protein. The findings have implications for our understanding of how the complex human brain evolved.
- David V. Hansen
- , Jan H. Lui
- & Arnold R. Kriegstein
Pyramidal neuron subtype diversity governs microglia states in the neocortex
Myelination and support of axonal integrity by glia