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A comprehensive transcriptional map of primate brain development
A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.
- Trygve E. Bakken
- , Jeremy A. Miller
- & Ed S. Lein
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Transcriptional landscape of the prenatal human brain
A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.
- Jeremy A. Miller
- , Song-Lin Ding
- & Ed S. Lein