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| Open AccessConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase
- Maria Agnese Morando
- , Giorgio Saladino
- & Francesco Luigi Gervasio
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| Open AccessDiscovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
- Marwa A. Aziz
- , Rabah A. T. Serya
- & Khaled A. M. Abouzid
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| Open AccessMechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa
- Jianming Zeng
- , Ni Zhang
- & Cha Chen
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| Open Accessp53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation
- Huan Jin
- , Shutao Yin
- & Hongbo Hu
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| Open AccessAn Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase
- Encarna Pucheta-Martínez
- , Giorgio Saladino
- & Francesco Luigi Gervasio
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Article
| Open AccessMitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis
- Santosh Karnewar
- , Sathish Babu Vasamsetti
- & Srigiridhar Kotamraju
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| Open AccessA Tricholoma matsutake Peptide with Angiotensin Converting Enzyme Inhibitory and Antioxidative Activities and Antihypertensive Effects in Spontaneously Hypertensive Rats
- Xueran Geng
- , Guoting Tian
- & Tzi Bun Ng
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| Open AccessAllosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin
- Stephen Verespy III
- , Akul Y. Mehta
- & Umesh R. Desai
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Article
| Open AccessIntegrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows
- He Tian
- , Nan Zheng
- & Jiaqi Wang
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| Open AccessSurface energetics and protein-protein interactions: analysis and mechanistic implications
- Claudio Peri
- , Giulia Morra
- & Giorgio Colombo
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Article
| Open AccessDiscovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
- Anasuya Chattopadhyay
- , Cornelius J. O’Connor
- & Laura S. Itzhaki
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Article
| Open AccessRevealing a new activity of the human Dicer DUF283 domain in vitro
- Anna Kurzynska-Kokorniak
- , Maria Pokornowska
- & Marek Figlerowicz
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Article
| Open AccessA novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis
- Wei Xu
- , Yangli Xie
- & Lin Chen
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Article
| Open AccessMolecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands
- Gerolamo Vettoretti
- , Elisabetta Moroni
- & Giorgio Colombo
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| Open AccessImbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors
- Mélaine A. Kuenemann
- , Céline M. Labbé
- & Olivier Sperandio
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Article
| Open AccessStructure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs
- Thommas M. Musyoka
- , Aquillah M. Kanzi
- & Özlem Tastan Bishop
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Article
| Open AccessDesign, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
- Santiago Schiaffino-Ortega
- , Eleonora Baglioni
- & Luisa Carlota López-Cara
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Article
| Open AccessA chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines
- Hui-Peng Song
- , Si-Qi Wu
- & Hua Yang
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Article
| Open AccessSubstrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition
- Prashant Kumar
- , Viktoria Reithofer
- & Karl Gruber
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Article
| Open AccessApplicability of the Rayleigh equation for enantioselective metabolism of chiral xenobiotics by microsomes, hepatocytes and in-vivo retention in rabbit tissues
- Shifra Jammer
- , Faina Gelman
- & Ovadia Lev
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Article
| Open AccessThe Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation
- Manish Dwivedi
- , Shahar Sukenik
- & Etana Padan
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Article
| Open AccessCoupling a DNA-Based Machine with Glucometer Readouts for Amplified Detection of Telomerase Activity in Cancer Cells
- Wenjing Wang
- , Shan Huang
- & Jun-Jie Zhu
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Article
| Open AccessAmyloid-like ribbons of amelogenins in enamel mineralization
- Karina M. M. Carneiro
- , Halei Zhai
- & Stefan Habelitz
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Article
| Open AccessSmall molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury
- Se-Yeon Lee
- , Seahyoung Lee
- & Ki-Chul Hwang
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Article
| Open AccessExtract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse
- Elizabeth Thomas
- , Vidya Gopalakrishnan
- & Sathees C. Raghavan
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Article
| Open AccessThe antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes
- Kantaraja Chindera
- , Manohar Mahato
- & Liam Good
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Article
| Open AccessThe conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria
- Maria Sofia Costa
- , Adriana Rego
- & Pedro N. Leão
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Article
| Open AccessThe fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development
- Nan Zhang
- , Francesca E. Duncan
- & Teresa K. Woodruff
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Article
| Open AccessThe nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome
- Philippa H. Harlow
- , Simon J. Perry
- & Anthony J. Flemming
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Article
| Open AccessFar-red/near-infrared fluorescence light-up probes for specific in vitro and in vivo imaging of a tumour-related protein
- Chao Chen
- , Yongquan Hua
- & Dan Ding
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Article
| Open AccessRepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles
- Cristina Fernández
- , Rafael Núñez-Ramírez
- & Rafael Giraldo
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Article
| Open AccessIdentification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA
- Thomas P. Schmidt
- , Anna M. Perna
- & Silja Wessler
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Article
| Open AccessImproved Production of Active Streptomyces griseus Trypsin with a Novel Auto-Catalyzed Strategy
- Yunfeng Zhang
- , Zhenmin Ling
- & Zhen Kang
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Article
| Open AccessLooking at the carcinogenicity of human insulin analogues via the intrinsic disorder prism
- Elrashdy M. Redwan
- , Moustafa H. Linjawi
- & Vladimir N. Uversky
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Article
| Open AccessA novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase
- Jung Hee Joo
- , Jeong-Eun Huh
- & Yun Soo Bae
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Article
| Open AccessA cationic tetrapyrrole inhibits toxic activities of the cellular prion protein
- Tania Massignan
- , Sara Cimini
- & Emiliano Biasini
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Article
| Open AccessMitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State
- Alessandra Folda
- , Anna Citta
- & Maria Pia Rigobello
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Article
| Open AccessIsoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice
- Yasuharu Watanabe
- , Yoshinori Nagai
- & Kiyoshi Takatsu
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Article
| Open AccessImpact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats
- Hongxing Han
- , Hailong Xiao
- & Zhenmei Lu
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Article
| Open AccessInsights into Adaptations to a Near-Obligate Nematode Endoparasitic Lifestyle from the Finished Genome of Drechmeria coniospora
- Liwen Zhang
- , Zhengfu Zhou
- & Min Lin
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Article
| Open AccessOlfactory perception and behavioral effects of sex pheromone gland components in Helicoverpa armigera and Helicoverpa assulta
- Meng Xu
- , Hao Guo
- & Chen-Zhu Wang
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Article
| Open AccessOvercoming doxorubicin resistance of cancer cells by Cas9-mediated gene disruption
- Jong Seong Ha
- , Juyoung Byun
- & Dae-Ro Ahn
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Article
| Open AccessTestis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76
- Xiaoli Wang
- , Han Li
- & Shi Chen
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Article
| Open AccessAntioxidant Lignans and Neolignans from Acorus tatarinowii
- Yuanyuan Lu
- , Yongbo Xue
- & Yonghui Zhang
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Article
| Open AccessThe three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition
- Deshuai Lou
- , Bochu Wang
- & Yue Wang
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Article
| Open AccessA critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus
- Yasuhiko Matsumoto
- , Jyunichiro Yasukawa
- & Kazuhisa Sekimizu
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Article
| Open AccessPEGylated substrates of NSP4 protease: A tool to study protease specificity
- Magdalena Wysocka
- , Natalia Gruba
- & Adam Lesner
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Article
| Open AccessA “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities
- Dongguo Lin
- , Fangfang Li
- & Jian He
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Article
| Open AccessMitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis
- Rahima Chennoufi
- , Houcine Bougherara
- & Eric Deprez
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