Mechanism of action articles within Scientific Reports

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• Article
  20 April 2024 | Open Access

  Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia

  • Zachary C. Rosenthal
  • , Daniel M. Fass
  •  & Stephen J. Haggarty

• Article
  19 January 2024 | Open Access

  A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition

  • Lilia Falkenstern
  • , Victoria Georgi
  •  & Amaury Fernández-Montalván

• Article
  27 November 2023 | Open Access

  Citronella essential oil-based nanoemulsion as a post-emergence natural herbicide

  • Naphat Somala
  • , Chamroon Laosinwattana
  •  & Montinee Teerarak

• Article
  20 November 2023 | Open Access

  Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches

  • Apramita Devi
  • , Morris Levin
  •  & Andrew L. Waterhouse

• Article
  30 October 2023 | Open Access

  A novel approach for predicting upstream regulators (PURE) that affect gene expression

  • Tuan-Minh Nguyen
  • , Douglas B. Craig
  •  & Sorin Draghici

• Article
  04 August 2023 | Open Access

  Cuticular property affects the insecticidal synergy of major constituents in thyme oil against houseflies, Musca domestica

  • Junho Yoon
  •  & Jun-Hyung Tak

• Article
  05 June 2023 | Open Access

  Acute exposure to organophosphorus pesticide metabolites compromises buffalo sperm function and impairs fertility

  • Shivani Chhillar
  • , Vipul Batra
  •  & Tirtha Kumar Datta

• Article
  04 May 2023 | Open Access

  Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition

  • Laurent Le Corre
  •  & Dominique Padovani

• Article
  29 March 2023 | Open Access

  Synthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents

  • Sora Cho
  • , Byoungjae Kong
  •  & Dae-Hyuk Kweon

• Article
  20 February 2023 | Open Access

  Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A

  • Pensiri Buacheen
  • , Jirarat Karinchai
  •  & Pornsiri Pitchakarn

• Article
  26 January 2023 | Open Access

  Synergy of ruthenium metallo-intercalator, [Ru(dppz)₂(PIP)]²⁺, with PARP inhibitor Olaparib in non-small cell lung cancer cells

  • Nur Aininie Yusoh
  • , Suet Lin Chia
  •  & Martin R. Gill

• Article
  23 June 2022 | Open Access

  Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats

  • Franklyn Nonso Iheagwam
  • , Olawumi Toyin Iheagwam
  •  & Shalom Nwodo Chinedu

• Article
  20 June 2022 | Open Access

  Appraisal of growth inhibitory, biochemical and genotoxic effects of Allyl Isothiocyanate on different developmental stages of Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae)

  • Sumit Singh
  • , Diksha
  •  & Satwinder Kaur Sohal

• Article
  08 June 2022 | Open Access

  Substrate-dependent modulation of the leukotriene A₄ hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation

  • Kyung Hyeon Lee
  • , Nadia Fazal Ali
  •  & Mikell Paige

• Article
  03 May 2022 | Open Access

  Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan

  • Miae Oh
  • , Jiah Yeom
  •  & Young-Hee Lim

• Article
  15 April 2022 | Open Access

  Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells

  • Masashi Kuriyama
  • , Hisaaki Hirose
  •  & Shiroh Futaki

• Article
  07 April 2022 | Open Access

  Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway

  • Winda Ariyani
  • , Wataru Miyazaki
  •  & Noriyuki Koibuchi

• Article
  08 March 2022 | Open Access

  Discovery of antimicrobials by massively parallelized growth assays (Me^x)

  • Philipp Koch
  • , Steven Schmitt
  •  & Martin Held

• Article
  07 February 2022 | Open Access

  The ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment

  • Jung-Kai Hsu
  • , Chia-Wei Weng
  •  & Peichen Janet Chen

• Article
  21 December 2021 | Open Access

  Molecular characterization and overexpression of the difenoconazole resistance gene CYP51 in Lasiodiplodia theobromae field isolates

  • Chenguang Wang
  • , Luxi Xu
  •  & Ye Yang

• Article
  21 December 2021 | Open Access

  Impact of Cymbopogon flexuosus (Poaceae) essential oil and primary components on the eclosion and larval development of Aedes aegypti

  • Ruth Mariela Castillo-Morales
  • , Sugey Ortiz Serrano
  •  & Jonny E. Duque

• Article
  07 December 2021 | Open Access

  Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules

  • Patrick Stoiber
  • , Pietro Scribani Rossi
  •  & Ulla Hansen

• Article
  12 November 2021 | Open Access

  Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

  • Hung Caohuy
  • , Ofer Eidelman
  •  & Harvey B. Pollard

• Article
  14 October 2021 | Open Access

  Biological activity of chitosan inducing resistance efficiency of rice (Oryza sativa L.) after treatment with fungal based chitosan

  • Vethamonickam Stanley-Raja
  • , Sengottayan Senthil-Nathan
  •  & Kandaswamy Kalaivani

• Article
  03 September 2021 | Open Access

  Epigallocatechin gallate inhibits release of extracellular vesicles from platelets without inhibiting phosphatidylserine exposure

  • Sarah L. Millington-Burgess
  •  & Matthew T. Harper

• Article
  10 May 2021 | Open Access

  Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia

  • Takashi Toyama
  • , Takayuki Hoshi
  •  & Gi-Wook Hwang

• Article
  22 January 2021 | Open Access

  Transcriptomic responses of Microcystis aeruginosa under electromagnetic radiation exposure

  • Chao Tang
  • , Ziyan Zhang
  •  & Peng Cai

• Article
  15 January 2021 | Open Access

  Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells

  • Nobuki Matsumoto
  • , Miku Ebihara
  •  & Toru Imamura

• Article
  12 January 2021 | Open Access

  Collapsed mitochondrial cristae in goat spermatozoa due to mercury result in lethality and compromised motility along with altered kinematic patterns

  • Bhawna Kushawaha
  • , Rajkumar Singh Yadav
  •  & Satish Kumar Garg

• Article
  12 January 2021 | Open Access

  Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages

  • Haidy A. Saleh
  • , Eman Ramdan
  •  & Anwar Abdelnaser

• Article
  08 January 2021 | Open Access

  Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes

  • Jason K. Cullen
  • , Glen M. Boyle
  •  & Craig M. Williams

• Article
  17 December 2020 | Open Access

  Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

  • Suzanne G. Mays
  • , Józef Stec
  •  & Eric A. Ortlund

• Article
  24 November 2020 | Open Access

  Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase

  • Pijush Kanti Pramanik
  • , Sajal Chakraborti
  •  & Tapati Chakraborti

• Article
  23 November 2020 | Open Access

  Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

  • Tao Yang
  • , Kevin C. Tran
  •  & Frank M. Longo

• Article
  15 October 2020 | Open Access

  The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics

  • Enea Sancho-Vaello
  • , David Gil-Carton
  •  & Kornelius Zeth

• Article
  14 October 2020 | Open Access

  Unique dynamic mode between Artepillin C and human serum albumin implies the characteristics of Brazilian green propolis representative bioactive component

  • Fan Wu
  • , Xin-Mi Song
  •  & Hong-Liang Li

• Article
  05 October 2020 | Open Access

  Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding

  • Jenny L. Hall
  • , Azmat Sohail
  •  & Fraser MacMillan

• Article
  13 August 2020 | Open Access

  Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

  • Sergey A. Goncharuk
  • , Lilya E. Artemieva
  •  & Konstantin S. Mineev

• Article
  11 August 2020 | Open Access

  Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H₃ receptor for Prader–Willi Syndrome

  • David Reiner
  • , Ludwig Seifert
  •  & Holger Stark

• Article
  30 July 2020 | Open Access

  Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms

  • Christopher Selleck
  • , Marcelo Monteiro Pedroso
  •  & Gerhard Schenk

• Article
  21 July 2020 | Open Access

  The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells

  • Dong Kyu Choi
  • , Young Kyu Kim
  •  & Ji Hoon Yu

• Article
  14 July 2020 | Open Access

  Bioactivity studies of porphyrinoids against microsporidia isolated from honeybees

  • Katarzyna Buczek
  • , Mariusz Trytek
  •  & Marek Tchórzewski

• Article
  01 July 2020 | Open Access

  Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation

  • Michael E. Stokes
  • , Jonnell Candice Small
  •  & Brent R. Stockwell

• Article
  29 June 2020 | Open Access

  Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study

  • Enrico Baruffini
  • , Roberta Ruotolo
  •  & Tiziana Lodi

• Article
  23 June 2020 | Open Access

  β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593

  • Suresh Panthee
  • , Naoko Kito
  •  & Shunji Takahashi

• Article
  15 June 2020 | Open Access

  Gene-signature-derived IC₅₀s/EC₅₀s reflect the potency of causative upstream targets and downstream phenotypes

  • Steffen Renner
  • , Christian Bergsdorf
  •  & Pierre Farmer

• Article
  18 May 2020 | Open Access

  Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics

  • Venkateswarlu Yarlagadda
  • , Ricardo Medina
  •  & Gerard D. Wright

• Article
  28 April 2020 | Open Access

  Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

  • Cristina Medina-Trillo
  • , Daniel M. Sedgwick
  •  & José Gallego

• Article
  19 March 2020 | Open Access

  A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage

  • Hao Su
  • , Caijuan Hu
  •  & Xueshi Huang

• Article
  07 February 2020 | Open Access

  Fluopack screening platform for unbiased cellular phenotype profiling

  • Zhao B. Kang
  • , Ioannis Moutsatsos
  •  & Christophe Antczak