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| Open Access
Mathematical topology and geometry-based classification of tauopathies
- Masumi Sugiyama
- , Kenneth S. Kosik
- & Eleni Panagiotou
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| Open Access
Binding and dimerization of PGLa peptides in anionic lipid bilayer studied by replica exchange molecular dynamics
- Steven R. Bowers
- , Christopher Lockhart
- & Dmitri K. Klimov
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| Open Access
Alternative conformations of a group 4 Late Embryogenesis Abundant protein associated to its in vitro protective activity
- David F. Rendón-Luna
- , Inti A. Arroyo-Mosso
- & Alejandra A. Covarrubias
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Article
| Open Access
Significant influence of four highly conserved amino-acids in lipochaperon-active sHsps on the structure and functions of the Lo18 protein
- Tiffany Bellanger
- , David da Silva Barreira
- & Stéphanie Weidmann
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Article
| Open Access
Amyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects
- Norihiro Namba
- , Takashi Ohgita
- & Hiroyuki Saito
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| Open Access
Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus
- Carl Johan Hagströmer
- , Jonas Hyld Steffen
- & Susanna Törnroth-Horsefield
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Article
| Open Access
Stress-mediated aggregation of disease-associated proteins in amyloid bodies
- Sahil Chandhok
- , Lionel Pereira
- & Timothy E. Audas
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| Open Access
Biochemical analysis of Komagataella phaffii oxidative folding proposes novel regulatory mechanisms of disulfide bond formation in yeast
- Arianna Palma
- , Lukas A. Rettenbacher
- & Lloyd Ruddock
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| Open Access
Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region
- Maud Chan-Yao-Chong
- , Justin Chan
- & Hidetoshi Kono
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| Open Access
The unusual properties of lactoferrin during its nascent phase
- Sara Notari
- , Giorgia Gambardella
- & Giorgio Ricci
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| Open Access
Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
- Chaitanya A. Patwardhan
- , Vamsi Krishna Kommalapati
- & Ahmed Chadli
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| Open Access
Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
- Donghee Lee
- , Ji Eun Ryoo
- & YoungSoo Kim
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| Open Access
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
- Takashi Ohgita
- , Hiroki Kono
- & Hiroyuki Saito
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| Open Access
The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae
- Rebecca Josefson
- , Navinder Kumar
- & Thomas Nyström
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| Open Access
A tile model of circuit topology for self-entangled biopolymers
- Erica Flapan
- , Alireza Mashaghi
- & Helen Wong
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| Open Access
DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin
- Lukas Becker
- & Andreas Plückthun
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| Open Access
Label-free autofluorescence lifetime reveals the structural dynamics of ataxin-3 inside droplets formed via liquid–liquid phase separation
- Uchu Matsuura
- , Shinya Tahara
- & Takakazu Nakabayashi
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| Open Access
Rational peptide design for inhibition of the KIX–MLL interaction
- Nao Sato
- , Shunji Suetaka
- & Munehito Arai
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| Open Access
Water stabilizes an alternate turn conformation in horse heart myoglobin
- Alex Bronstein
- & Ailie Marx
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| Open Access
Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins
- Ayaka Tomihari
- , Mako Kiyota
- & Eisuke Itakura
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| Open Access
Heat shock protein A2 is a novel extracellular vesicle-associated protein
- Damian Robert Sojka
- , Agata Abramowicz
- & Dorota Scieglinska
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| Open Access
Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase and implications for PFAS (per- and polyfluoroalkyl substance) biodegradation
- Hao-Bo Guo
- , Vanessa A. Varaljay
- & Rajiv Berry
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| Open Access
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death
- Sofia Pavlou
- , Stefanie Foskolou
- & Emmanouil Metzakopian
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| Open Access
Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides
- Elina Berntsson
- , Faraz Vosough
- & Sebastian K. T. S. Wärmländer
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| Open Access
Food protein-derived amyloids do not accelerate amyloid β aggregation
- M. Mahafuzur Rahman
- , Rodrigo Sanches Pires
- & Christofer Lendel
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| Open Access
Machine learning approaches demonstrate that protein structures carry information about their genetic coding
- Linor Ackerman-Schraier
- , Aviv A. Rosenberg
- & Alex M. Bronstein
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Editorial
| Open AccessAmyloids in synthetic applications
More than a century after the first description of amyloids by Alois Alzheimer, and despite the enormous research efforts since then, the field is still full of surprises. While searching for answers to questions for example on the driving force, mechanism, and regulation of amyloidogenesis, or on the structure, physiological and pathological roles of different amyloid aggregates, unexpected properties are regularly revealed, broadening their application possibilities. This Collection aims to focus on the beneficial sides of amyloid formation, primarily exploring the potential use of amyloids in material science, bioengineering, and synthetic chemistry.
- Marianna Török
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Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage
- Alkmini A. Papadopoulou
- , Walter Stelzer
- & Regina Fluhrer
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| Open Access
Structural informatic study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water-soluble QTY variants
- Eva Smorodina
- , Igor Diankin
- & Shuguang Zhang
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| Open Access
Hereditary spastic paraplegia SPG13 mutation increases structural stability and ATPase activity of human mitochondrial chaperonin
- Lingling Chen
- , Aiza Syed
- & Adhitya Balaji
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| Open Access
Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms
- Kyle Kim
- , Lance A. Safarta
- & Jonathan H. Lin
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| Open Access
Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
- Juan Luis Pacheco-García
- , Dmitry S. Loginov
- & Angel L. Pey
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| Open Access
Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules
- Daisuke Fujinami
- , Seiichiro Hayashi
- & Daisuke Kohda
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| Open Access
Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates
- Ryota Hikiami
- , Toshifumi Morimura
- & Makoto Urushitani
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| Open Access
Twin-arginine translocase component TatB performs folding quality control via a chaperone-like activity
- May N. Taw
- , Jason T. Boock
- & Matthew P. DeLisa
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| Open Access
Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption
- Marc-Antoine Campeau
- & Richard L. Leask
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| Open Access
A field-deployable diagnostic assay for the visual detection of misfolded prions
- Peter R. Christenson
- , Manci Li
- & Peter A. Larsen
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| Open Access
Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis
- Hamza Mameri
- , Jean-Charles Gaudin
- & Sandra Denery-Papini
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| Open Access
Spatial organization of hydrophobic and charged residues affects protein thermal stability and binding affinity
- Fausta Desantis
- , Mattia Miotto
- & Giancarlo Ruocco
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| Open Access
Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
- Takumi Taketomi
- , Takunori Yasuda
- & Fuminori Tsuruta
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Article
| Open Access
Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans
- Silvestar Beljan
- , Kristina Dominko
- & Helena Ćetković
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| Open Access
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
- Hao-Bo Guo
- , Alexander Perminov
- & Rajiv Berry
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| Open Access
A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody
- Madeleine Reilly
- , Iryna Benilova
- & John Collinge
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Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
- Raju Dash
- , Yeasmin Akter Munni
- & Il Soo Moon
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A comparative study of unpasteurized and pasteurized frozen whole hen eggs using size-exclusion chromatography and small-angle X-ray scattering
- Yoshiki Oka
- , Hiroko Yukawa
- & Munehito Arai
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| Open Access
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells
- Hiroki Tanemura
- , Kenji Masuda
- & Ryo Ushioda
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| Open Access
Differences in interaction lead to the formation of different types of insulin amyloid
- Wakako Mori
- , Ryosuke Kawakami
- & Tamotsu Zako
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Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
- Takashi Ohgita
- , Norihiro Namba
- & Hiroyuki Saito
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Proteome-wide landscape of solubility limits in a bacterial cell
- Ádám Györkei
- , Lejla Daruka
- & Balázs Papp
An aberrant fused in sarcoma liquid droplet of amyotrophic lateral sclerosis pathological variant, R495X, accelerates liquid–solid phase transition