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Identification and structural characterization of small molecule inhibitors of PINK1
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Effects of psychological stress on the emission of volatile organic compounds from the skin
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A kinetic-based stopped-flow DPPH• method
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Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition
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Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
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Synthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents
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Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi
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A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
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Development of a novel light-up probe for detection of G-quadruplexes in stress granules
- Keisuke Iida
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Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine
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Substrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation
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Comprehensive metabolomics unveil the discriminatory metabolites of some Mediterranean Sea marine algae in relation to their cytotoxic activities
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A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
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Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons
- Alessandro Soloperto
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Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
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Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
- Giacomo G. Rossetti
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Targeted isolation of photoactive pigments from mushrooms yielded a highly potent new photosensitizer: 7,7′-biphyscion
- Fabian Hammerle
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Breath biomarkers of insulin resistance in pre-diabetic Hispanic adolescents with obesity
- Mohammad S. Khan
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DNA binding by the antimalarial compound artemisinin
- Sladjana Slavkovic
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Chemical strategies for triggering the immune response to the mycotoxin patulin
- Hadyn Duncan
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Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids
- Meng Cui
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Comparison of bacteria disintegration methods and their influence on data analysis in metabolomics
- Karolina Anna Mielko
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The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages
- Wenyun Zeng
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Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy
- Samantha T. Reyes
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Substituted 1,2,3-triazoles: a new class of nitrification inhibitors
- Bethany I. Taggert
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Development and validation of HPLC-MS2 methodology for the accurate determination of C4–C8 B-type flavanols and procyanidins
- Ugo Bussy
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Isolation and structure elucidation of pyridine alkaloids from the aerial parts of the Mongolian medicinal plant Caryopteris mongolica Bunge
- Dumaa Mishig
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Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro
- Eva Doleželová
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In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin
- Sakshi Piplani
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Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
- Sohui Park
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A novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
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Zinc oxide nanoparticles improve testicular steroidogenesis machinery dysfunction in benzo[α]pyrene-challenged rats
- Niveen M. Daoud
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Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers
- Martina Meßner
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A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
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In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer
- Z. Ping Lin
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Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
- Ewelina Weglarz-Tomczak
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Terroir and vintage discrimination of Malbec wines based on phenolic composition across multiple sites in Mendoza, Argentina
- Roy Urvieta
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Breath can discriminate tuberculosis from other lower respiratory illness in children
- Carly A. Bobak
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Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations
- Karsten Burkert
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Enzyme and lateral flow monoclonal antibody-based immunoassays to simultaneously determine spirotetramat and spirotetramat-enol in foodstuffs
- Ramón E. Cevallos-Cedeño
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Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models
- Vishal B. Siramshetty
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Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives
- Dicky Annas
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Diversity of secoiridoid glycosides in leaves of UK and Danish ash provide new insight for ash dieback management
- John D. Sidda
- , Lijiang Song
- & Murray Grant
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Synthesis of two new lipid mediators from docosahexaenoic acid by combinatorial catalysis involving enzymatic and chemical reaction
- Jong-Jae Yi
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- & Jeong-Woo Seo
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Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide
- Radosław Michalski
- , David Thiebaut
- & Adam Sikora
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Simulations on the dual effects of flavonoids as suppressors of Aβ42 fibrillogenesis and destabilizers of mature fibrils
- Sahar Andarzi Gargari
- & Abolfazl Barzegar
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Bardoxolone conjugation enables targeted protein degradation of BRD4
- Bingqi Tong
- , Mai Luo
- & Daniel K. Nomura
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Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii
- Micah Dettweiler
- , Lewis Marquez
- & Cassandra L. Quave
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Effects of time and temperature during melanging on the volatile profile of dark chocolate
- Caitlin Clark
- , Harmonie M. Bettenhausen
- & Martha Stone
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia