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| Open AccessPrevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism
- Takuya Nagashima
- , Hisashi Shirakawa
- & Shuji Kaneko
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Article
| Open AccessAn in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia
- Yasuhiko Matsumoto
- , Masaki Ishii
- & Kazuhisa Sekimizu
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Article
| Open AccessProteome-wide drug screening using mass spectrometric imaging of bead-arrays
- Ying Zhou
- , Ziying Liu
- & Mark J. Lim
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| Open AccessNovel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune
- Weiguang Sun
- , Xintao Chen
- & Yonghui Zhang
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Article
| Open AccessBioactivity of 2′-deoxyinosine-incorporated aptamer AS1411
- Xinmeng Fan
- , Lidan Sun
- & Zhenjun Yang
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Article
| Open AccessMechanistic insight into cadmium-induced inactivation of the Bloom protein
- Wei Qin
- , Nicolas Bazeille
- & Xu-Guang Xi
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| Open AccessA novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase
- Joosu Kuivanen
- , Maura H. Sugai-Guérios
- & Peter Richard
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| Open AccessMetabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia
- Liang Cui
- , Dahai Zheng
- & Choon Nam Ong
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Article
| Open AccessVisible-light photoredox synthesis of unnatural chiral α-amino acids
- Min Jiang
- , Yunhe Jin
- & Hua Fu
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| Open AccessCombination of deep eutectic solvent and ionic liquid to improve biocatalytic reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cell
- Pei Xu
- , Peng-Xuan Du
- & Wen-Yong Lou
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Article
| Open AccessRegulation of Irregular Neuronal Firing by Autaptic Transmission
- Daqing Guo
- , Shengdun Wu
- & Dezhong Yao
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Article
| Open AccessImaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes
- Shimpei Iikuni
- , Masahiro Ono
- & Hideo Saji
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Article
| Open AccessRinghalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex
- Bhaskar Barnwal
- , Chacko Jobichen
- & R. Manjunatha Kini
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| Open AccessApplication of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform
- Xiangmin Miao
- , Chao Yang
- & Dik-Lung Ma
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Article
| Open AccessStructural investigation into physiological DNA phosphorothioate modification
- Wenxian Lan
- , Zhongpei Hu
- & Chunyang Cao
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Article
| Open AccessMuc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding
- Ana Magalhães
- , Yannick Rossez
- & Celso A. Reis
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Article
| Open AccessBRAID: A Unifying Paradigm for the Analysis of Combined Drug Action
- Nathaniel R. Twarog
- , Elizabeth Stewart
- & Anang A. Shelat
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Article
| Open AccessN6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
- Shui Zou
- , Joel D. W. Toh
- & Esther C. Y. Woon
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Article
| Open AccessInhibition of cyclic diadenylate cyclase, DisA, by polyphenols
- Clement Opoku-Temeng
- & Herman O. Sintim
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Article
| Open AccessA platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors
- Yuming Wei
- , Daniel C. Poon
- & Kenneth K. W. To
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Article
| Open AccessAn Evaluation of Blood Compatibility of Silver Nanoparticles
- He Huang
- , Wenjia Lai
- & Liming Xie
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Article
| Open AccessIdentification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production
- Andy M. Bailey
- , Fabrizio Alberti
- & Gary D. Foster
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Article
| Open AccessSpecific Cues Associated With Honey Bee Social Defence against Varroa destructor Infested Brood
- Fanny Mondet
- , Seo Hyun Kim
- & Alison R. Mercer
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Article
| Open AccessSequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility
- Zhongli Xu
- , Susanne von Grafenstein
- & Michaela Schmidtke
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Article
| Open AccessBufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
- Qiang Xiao
- , Ningning Dong
- & Weiqiang Lu
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Article
| Open AccessEnantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations
- Zhaodi Wu
- , Yongji Lai
- & Yonghui Zhang
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Article
| Open AccessScreening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX
- Yuqian Long
- , Zhiqiang Qin
- & Weihong Tan
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Article
| Open AccessLovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade
- Chia-Sheng Yen
- , Jung-Chien Chen
- & Ming-Jen Hsu
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Article
| Open AccessDiscovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury
- Yali Zhang
- , Jianzhang Wu
- & Guang Liang
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Article
| Open AccessCombining measurements to estimate properties and characterization extent of complex biochemical mixtures; applications to Heparan Sulfate
- Joël R. Pradines
- , Daniela Beccati
- & Ishan Capila
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Article
| Open AccessPlasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2
- Zhong-Hua Gao
- , Yi-Ming Shi
- & Wei-Lie Xiao
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| Open AccessA upconversion luminescene biosensor based on dual-signal amplification for the detection of short DNA species of c-erbB-2 oncogene
- Jianming Lan
- , Yingxin Liu
- & Jinghua Chen
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Article
| Open AccessThioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes
- Shujuan Xu
- , Qian Li
- & Yalin Tang
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Article
| Open AccessYeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore
- Sergio Couoh-Cardel
- , Yi-Ching Hsueh
- & Liviu Movileanu
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| Open AccessOne-pot non-enzymatic formation of firefly luciferin in a neutral buffer from p-benzoquinone and cysteine
- Shusei Kanie
- , Toshio Nishikawa
- & Yuichi Oba
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| Open AccessRegiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum
- Xiaoman Yang
- , Jiali Yang
- & Bao Yang
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Article
| Open AccessIdentification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution
- Terumasa Nakamoto
- , Miki Miyanokoshi
- & Keisuke Wakasugi
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Article
| Open AccessDrug target identification using network analysis: Taking active components in Sini decoction as an example
- Si Chen
- , Hailong Jiang
- & Yifeng Chai
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Article
| Open AccessReceptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
- Vernon Seow
- , Junxian Lim
- & David P. Fairlie
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Article
| Open AccessA MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells
- Kyoung-Jin Kim
- , Hee-Jin Kim
- & Yun-Gon Kim
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Article
| Open AccessGene set of chemosensory receptors in the polyembryonic endoparasitoid Macrocentrus cingulum
- Tofael Ahmed
- , Tiantao Zhang
- & Shuxiong Bai
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Article
| Open AccessConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase
- Maria Agnese Morando
- , Giorgio Saladino
- & Francesco Luigi Gervasio
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Article
| Open AccessDiscovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
- Marwa A. Aziz
- , Rabah A. T. Serya
- & Khaled A. M. Abouzid
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Article
| Open AccessMechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa
- Jianming Zeng
- , Ni Zhang
- & Cha Chen
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Article
| Open Accessp53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation
- Huan Jin
- , Shutao Yin
- & Hongbo Hu
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Article
| Open AccessAn Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase
- Encarna Pucheta-Martínez
- , Giorgio Saladino
- & Francesco Luigi Gervasio
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Article
| Open AccessMitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis
- Santosh Karnewar
- , Sathish Babu Vasamsetti
- & Srigiridhar Kotamraju
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Article
| Open AccessA Tricholoma matsutake Peptide with Angiotensin Converting Enzyme Inhibitory and Antioxidative Activities and Antihypertensive Effects in Spontaneously Hypertensive Rats
- Xueran Geng
- , Guoting Tian
- & Tzi Bun Ng
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Article
| Open AccessAllosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin
- Stephen Verespy III
- , Akul Y. Mehta
- & Umesh R. Desai
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