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| Open AccessA platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors
- Yuming Wei
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| Open AccessAn Evaluation of Blood Compatibility of Silver Nanoparticles
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| Open AccessIdentification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production
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| Open AccessSpecific Cues Associated With Honey Bee Social Defence against Varroa destructor Infested Brood
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| Open AccessSequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility
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| Open AccessBufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
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| Open AccessEnantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations
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| Open AccessScreening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX
- Yuqian Long
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| Open AccessLovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade
- Chia-Sheng Yen
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| Open AccessDiscovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury
- Yali Zhang
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- & Guang Liang
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| Open AccessCombining measurements to estimate properties and characterization extent of complex biochemical mixtures; applications to Heparan Sulfate
- Joël R. Pradines
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| Open AccessPlasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2
- Zhong-Hua Gao
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| Open AccessA upconversion luminescene biosensor based on dual-signal amplification for the detection of short DNA species of c-erbB-2 oncogene
- Jianming Lan
- , Yingxin Liu
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| Open AccessThioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes
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| Open AccessYeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore
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| Open AccessOne-pot non-enzymatic formation of firefly luciferin in a neutral buffer from p-benzoquinone and cysteine
- Shusei Kanie
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- & Yuichi Oba
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| Open AccessRegiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum
- Xiaoman Yang
- , Jiali Yang
- & Bao Yang
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| Open AccessIdentification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution
- Terumasa Nakamoto
- , Miki Miyanokoshi
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| Open AccessDrug target identification using network analysis: Taking active components in Sini decoction as an example
- Si Chen
- , Hailong Jiang
- & Yifeng Chai
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| Open AccessReceptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
- Vernon Seow
- , Junxian Lim
- & David P. Fairlie
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| Open AccessA MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells
- Kyoung-Jin Kim
- , Hee-Jin Kim
- & Yun-Gon Kim
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| Open AccessGene set of chemosensory receptors in the polyembryonic endoparasitoid Macrocentrus cingulum
- Tofael Ahmed
- , Tiantao Zhang
- & Shuxiong Bai
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| Open AccessConformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase
- Maria Agnese Morando
- , Giorgio Saladino
- & Francesco Luigi Gervasio
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| Open AccessDiscovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
- Marwa A. Aziz
- , Rabah A. T. Serya
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| Open AccessMechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa
- Jianming Zeng
- , Ni Zhang
- & Cha Chen
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| Open Accessp53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation
- Huan Jin
- , Shutao Yin
- & Hongbo Hu
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| Open AccessAn Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase
- Encarna Pucheta-Martínez
- , Giorgio Saladino
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| Open AccessMitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis
- Santosh Karnewar
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- & Srigiridhar Kotamraju
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| Open AccessA Tricholoma matsutake Peptide with Angiotensin Converting Enzyme Inhibitory and Antioxidative Activities and Antihypertensive Effects in Spontaneously Hypertensive Rats
- Xueran Geng
- , Guoting Tian
- & Tzi Bun Ng
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| Open AccessAllosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin
- Stephen Verespy III
- , Akul Y. Mehta
- & Umesh R. Desai
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| Open AccessIntegrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows
- He Tian
- , Nan Zheng
- & Jiaqi Wang
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| Open AccessSurface energetics and protein-protein interactions: analysis and mechanistic implications
- Claudio Peri
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| Open AccessDiscovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
- Anasuya Chattopadhyay
- , Cornelius J. O’Connor
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| Open AccessRevealing a new activity of the human Dicer DUF283 domain in vitro
- Anna Kurzynska-Kokorniak
- , Maria Pokornowska
- & Marek Figlerowicz
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| Open AccessA novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis
- Wei Xu
- , Yangli Xie
- & Lin Chen
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| Open AccessMolecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands
- Gerolamo Vettoretti
- , Elisabetta Moroni
- & Giorgio Colombo
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| Open AccessImbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors
- Mélaine A. Kuenemann
- , Céline M. Labbé
- & Olivier Sperandio
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| Open AccessStructure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs
- Thommas M. Musyoka
- , Aquillah M. Kanzi
- & Özlem Tastan Bishop
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| Open AccessDesign, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
- Santiago Schiaffino-Ortega
- , Eleonora Baglioni
- & Luisa Carlota López-Cara
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| Open AccessA chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines
- Hui-Peng Song
- , Si-Qi Wu
- & Hua Yang
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| Open AccessSubstrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition
- Prashant Kumar
- , Viktoria Reithofer
- & Karl Gruber
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| Open AccessApplicability of the Rayleigh equation for enantioselective metabolism of chiral xenobiotics by microsomes, hepatocytes and in-vivo retention in rabbit tissues
- Shifra Jammer
- , Faina Gelman
- & Ovadia Lev
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| Open AccessThe Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation
- Manish Dwivedi
- , Shahar Sukenik
- & Etana Padan
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| Open AccessCoupling a DNA-Based Machine with Glucometer Readouts for Amplified Detection of Telomerase Activity in Cancer Cells
- Wenjing Wang
- , Shan Huang
- & Jun-Jie Zhu
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Article
| Open AccessAmyloid-like ribbons of amelogenins in enamel mineralization
- Karina M. M. Carneiro
- , Halei Zhai
- & Stefan Habelitz
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| Open AccessSmall molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury
- Se-Yeon Lee
- , Seahyoung Lee
- & Ki-Chul Hwang
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Article
| Open AccessExtract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse
- Elizabeth Thomas
- , Vidya Gopalakrishnan
- & Sathees C. Raghavan
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Article
| Open AccessThe antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes
- Kantaraja Chindera
- , Manohar Mahato
- & Liam Good
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| Open AccessThe conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria
- Maria Sofia Costa
- , Adriana Rego
- & Pedro N. Leão
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