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| Open AccessRisk-adapted locoregional radiotherapy strategies based on a prognostic nomogram for de novo metastatic nasopharyngeal carcinoma patients treated with chemoimmunotherapy
- Yuebing Chen
- , Chuying Chen
- & Cheng Lin
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| Open AccessBAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health
- Hien Thi Tran
- , Murphy Lam Yim Wan
- & Catharina Svanborg
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| Open AccessAn inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer
- Mauricio Jacobo Jacobo
- , Hayley J. Donnella
- & Sourav Bandyopadhyay
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| Open AccessDistinguishing recurrence from radiation-induced lung injury at the time of RECIST progressive disease on post-SABR CT scans using radiomics
- Salma Dammak
- , Stephanie Gulstene
- & Aaron D. Ward
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| Open AccessThe Temozolomide–Doxorubicin paradox in Glioblastoma in vitro–in silico preclinical drug-screening
- Mariam-Eleni Oraiopoulou
- , Eleftheria Tzamali
- & Vangelis Sakkalis
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| Open AccessComparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study
- Mahdiyeh Bakhtiyari-Ramezani
- , Mojtaba Nohekhan
- & Meysam Nasiri
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| Open AccessNavigating the nuances: comparative analysis and hyperparameter optimisation of neural architectures on contrast-enhanced MRI for liver and liver tumour segmentation
- Felix Quinton
- , Benoit Presles
- & Jean-Louis Alberini
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| Open AccessA TME-activated nano-catalyst for triple synergistic therapy of colorectal cancer
- Qiang Liu
- , Yurong Xiang
- & Zheng Xiang
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| Open AccessComparative overall survival of CDK4/6 inhibitors in combination with endocrine therapy in advanced breast cancer
- Coralea Kappel
- , Mitchell J. Elliott
- & Eitan Amir
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| Open AccessMolecular crosstalk between MUC1 and STAT3 influences the anti-proliferative effect of Napabucasin in epithelial cancers
- Mukulika Bose
- , Alexa Sanders
- & Pinku Mukherjee
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| Open AccessZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells
- David Mai
- , Tifara Boyce
- & Carl H. June
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| Open AccessExtending deterministic transport capabilities for very-high and ultra-high energy electron beams
- Ahmed Naceur
- , Charles Bienvenue
- & Jean-François Carrier
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| Open AccessA novel exosome based therapeutic intervention against neuroendocrine prostate cancer
- Sharanjot Saini
- , Amritha Sreekumar
- & Matthew N. Simmons
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| Open AccessIn vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- Shaimaa E. Diab
- , Nourhan A. Tayea
- & Zakia A. Olama
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| Open AccessSingle-cell analysis reveals ADGRL4+ renal tubule cells as a highly aggressive cell type in clear cell renal cell carcinoma
- Zehua Wang
- & Zhongxiao Zhang
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| Open AccessThe boundary of posterior to level V region and the theoretical feasibility of irradiation dose reduction of level Va in nasopharyngeal carcinoma
- Chaoyang Jiang
- , Xiaokai Li
- & Juan Wang
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| Open AccessA novel CT-based radiomics model for predicting response and prognosis of chemoradiotherapy in esophageal squamous cell carcinoma
- Akinari Kasai
- , Jinsei Miyoshi
- & Tetsuji Takayama
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| Open AccessTranscriptomic and proteomic analysis of tumor suppressive effects of GZ17-6.02 against mycosis fungoides
- Zachary A. Bordeaux
- , Sriya V. Reddy
- & Madan M. Kwatra
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| Open AccessTherapy-induced modulation of tumor vasculature and oxygenation in a murine glioblastoma model quantified by deep learning-based feature extraction
- Nadine Bauer
- , Daniel Beckmann
- & Friedemann Kiefer
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Article
| Open AccessImpact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells
- Sua Cho
- , Wonjin Kim
- & Misu Lee
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Article
| Open AccessA new (T-X\(^\theta\)) family of distributions: properties, discretization and estimation with applications
- Rasha M. Mandouh
- , Mahmoud R. Mahmoud
- & Rasha E. Abdelatty
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Article
| Open AccessDevelopment of a claims-based risk-scoring model to predict emergency department visits in older patients receiving anti-neoplastic therapy
- Yewon Suh
- , Jonghyun Jeong
- & Ju-Yeun Lee
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| Open AccessPrognostic significance of pretreatment albumin–bilirubin (ALBI) grade and platelet–albumin–bilirubin (PALBI) grade in patients with small cell lung cancer
- Engin Kut
- & Serkan Menekse
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Article
| Open AccessPreparation of stable colloidal dispersion of surface modified Fe3O4 nanoparticles for magnetic heating applications
- Behnam Sabzi Dizajyekan
- , Arezou Jafari
- & Zahra Fakhroueian
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Editorial
| Open AccessAdvancing cancer immunotherapy: from innovative preclinical models to clinical insights
The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some cancer types. Many gaps still exist, however, in the scientific knowledge of immune dysfunction in the tumour microenvironment and predicting clinical immunotherapy response to allow more cancer patients to benefit from immunotherapy. The Cancer Immunotherapy Collection within Scientific Reports describes pioneering preclinical and clinical studies addressing these concepts, representing significant insights and breakthroughs in the field.
- Andrew W. Craig
- , Hermann B. Frieboes
- & Paula A. Videira
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| Open AccessChemotherapy is of prognostic significance to metaplastic breast cancer
- Meilin Zhang
- , Jingjing Yuan
- & Hongliang Chen
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| Open AccessEffectiveness of adjuvant systemic therapy following complete cytoreductive surgery in patients with recurrent granulosa cell tumours of the ovary
- Harika Yumru Celiksoy
- , Catriona Dickie
- & Christina Fotopoulou
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| Open AccessPaclitaxel-induced inhibition of NSCLC invasion and migration via RBFOX3-mediated circIGF1R biogenesis
- Zhanyu Xu
- , Liping Zheng
- & Shikang Li
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Article
| Open AccessRadiation-induced changes in energy metabolism result in mitochondrial dysfunction in salivary glands
- Lauren G. Buss
- , Brenna A. Rheinheimer
- & Kirsten H. Limesand
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Article
| Open AccessFGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models
- Kristianne J. C. Galpin
- , Galaxia M. Rodriguez
- & Barbara C. Vanderhyden
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Article
| Open AccessDosimetric characterization of a novel UHDR megavoltage X-ray source for FLASH radiobiological experiments
- Nolan Esplen
- , Luca Egoriti
- & Magdalena Bazalova-Carter
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Article
| Open AccessStructural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab
- Nicholas Lorig-Roach
- , Nina M. Harpell
- & Rebecca M. DuBois
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Article
| Open AccessApalutamide versus bicalutamide in combination with androgen deprivation therapy for metastatic hormone sensitive prostate cancer
- Takashi Ueda
- , Takumi Shiraishi
- & Osamu Ukimura
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Article
| Open AccessSerine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer
- Tao He
- , Nan-Xing Li
- & Jun Zou
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Article
| Open AccessITGB1 and DDR activation as novel mediators in acquired resistance to osimertinib and MEK inhibitors in EGFR-mutant NSCLC
- Caterina De Rosa
- , Viviana De Rosa
- & Carminia Maria Della Corte
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| Open AccessImmune, metabolic landscapes of prognostic signatures for lung adenocarcinoma based on a novel deep learning framework
- Shimei Qin
- , Shibin Sun
- & Lina Chen
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Article
| Open AccessPRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo
- Elizabeth J. Brown
- , Leire Balaguer-Lluna
- & Gillian Farnie
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Article
| Open AccessClass II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer
- Cindy Y. Jiang
- , Lili Zhao
- & Nithya Ramnath
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Article
| Open AccessUsing the photon isoeffective dose formalism to compare and combine BNCT and CIRT in a head and neck tumour
- Ian Postuma
- , Chiara Magni
- & Silva Bortolussi
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Article
| Open AccessImpact of radiation doses on clinical relapse of biochemically recurrent prostate cancer after prostatectomy
- Seiya Takano
- , Natsuo Tomita
- & Akio Hiwatashi
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Article
| Open AccessInhibition of DNMT3B expression in activated hepatic stellate cells overcomes chemoresistance in the tumor microenvironment of hepatocellular carcinoma
- Yeonhwa Song
- , Namjeong Kim
- & Haeng Ran Seo
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Article
| Open AccessEstablishment and validation of nomogram models for overall survival and cancer-specific survival in spindle cell sarcoma patients
- Weihui Qi
- , Yanyun Ren
- & Hao Pan
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Article
| Open AccessTargeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2MUT ovarian cancer cells
- Łukasz Biegała
- , Arkadiusz Gajek
- & Aneta Rogalska
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Article
| Open AccessExperimental study on Compton camera for boron neutron capture therapy applications
- M. Sakai
- , S. Tamaki
- & M. Tashiro
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Article
| Open AccessArtesunate acts through cytochrome c to inhibit growth of pediatric AML cells
- Kristen S. Hill
- , Erin E. Schuler
- & Jill M. Kolesar
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Article
| Open AccessA three-gene signature reveals changes in the tumor immune microenvironment in the progression from NAFLD to HCC
- Lijuan Liu
- , Haonan Tang
- & Guanqiao Jin
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Article
| Open AccessKTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line
- Nguyen Huy Du
- , Truong Thi Bich Ngoc
- & Dang Thi Phuong Thao
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Article
| Open AccessLong-term findings of rectal endoscopy and rectal bleeding after moderately hypofractionated, intensity-modulated radiotherapy for prostate cancer
- Bong Kyung Bae
- , Ji Eun Kim
- & Won Park
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Article
| Open AccessInfluence of pneumatic transportation on the stability of monoclonal antibodies
- Pierre Coliat
- , Stéphane Erb
- & Xavier Pivot