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Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity
- Masaaki Akai
- , Kazuhiro Noma
- & Toshiyoshi Fujiwara
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Platelets induce CD39 expression in tumor cells to facilitate tumor metastasis
- Zhaochen Ning
- , Keyan Liu
- & Huabao Xiong
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Pirfenidone alleviates fibrosis by acting on tumour–stroma interplay in pancreatic cancer
- Yalan Lei
- , Jin Xu
- & Si Shi
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Article
| Open Access
Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma
- Yusuke Matoba
- , Dominique T. Zarrella
- & Bo R. Rueda
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Article
| Open Access
Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy
- Hye Hyeon Eum
- , Dasom Jeong
- & Hae-Ock Lee
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Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients
- Don Pietro Saldajeno
- , Shinpei Kawaoka
- & Masakazu Toi
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Article
| Open Access
Integrative score based on CDK6, PD-L1 and TMB predicts response to platinum-based chemotherapy and PD-1/PD-L1 blockade in muscle-invasive bladder cancer
- Xiaohe Su
- , Kaifeng Jin
- & Jiejie Xu
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Article
| Open Access
Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis
- Xiaobo Fu
- , Siming Liu
- & Gang Wang
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PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells
- Sarah Wang
- , Caroline P. Riedstra
- & Andrew C. Dudley
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Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma
- Bin Zhang
- , Xiaofeng Guo
- & Quanbo Zhou
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Periostin–TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer
- Bin Liu
- , Tiantian Wu
- & Gaoliang Ouyang
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Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
- Emre Küçükköse
- , Matthijs J. D. Baars
- & Yvonne Vercoulen
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Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancer
- Xu Guan
- , Pu Cheng
- & Xishan Wang
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Review Article
| Open Access
The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control
- Jinhai Deng
- , Teng Pan
- & Tony Ng
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Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer
- Masayuki Shirasawa
- , Tatsuya Yoshida
- & Yuichiro Ohe
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The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer
- Jie Mei
- , Yun Cai
- & Yan Zhang
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Blocking of oestrogen signals improves anti-tumour effect regardless of oestrogen receptor alpha expression in cancer cells
- Nabeel Kajihara
- , Yunqi Ge
- & Ken-ichiro Seino
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Immune microenvironment and lymph node yield in colorectal cancer
- Soo Hyun Lee
- , Amaya Pankaj
- & Osman Yılmaz
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Article
| Open Access
C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer
- Xin Liu
- , Kunpeng Lv
- & Jiejie Xu
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Ponatinib delays the growth of solid tumours by remodelling immunosuppressive tumour microenvironment through the inhibition of induced PD-L1 expression
- Anjali Barnwal
- , Rohini Tamang
- & Jayanta Bhattacharyya
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Article
| Open Access
Technical development and validation of a clinically applicable microenvironment classifier as a biomarker of tumour hypoxia for soft tissue sarcoma
- Laura J. Forker
- , Becky Bibby
- & Catharine West
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Review Article |
HIF2α, Hepcidin and their crosstalk as tumour-promoting signalling
- Vincenzo Formica
- , Silvia Riondino
- & Mario Roselli
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Article
| Open Access
Irradiation plus myeloid-derived suppressor cell-targeted therapy for overcoming treatment resistance in immunologically cold urothelial carcinoma
- Shoma Yamamoto
- , Minoru Kato
- & Junji Uchida
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Article
| Open Access
Immunological and prognostic significance of tumour necrosis in colorectal cancer
- Meeri Kastinen
- , Päivi Sirniö
- & Juha P. Väyrynen
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Tumour infiltrating lymphocytes and survival after adjuvant chemotherapy in patients with gastric cancer: post-hoc analysis of the CLASSIC trial
- Drolaiz H. W. Liu
- , Young-Woo Kim
- & Heike I. Grabsch
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Article
| Open Access
Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors
- Yoshinori Hayashi
- , Tomoki Makino
- & Yuichiro Doki
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A multimodal imaging study to highlight elastin-derived peptide pro-tumoral effect in a pancreatic xenograft model
- Lise Nannan
- , Willy Gsell
- & Bertrand Brassart
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Article
| Open Access
Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
- Hanna Elomaa
- , Maarit Ahtiainen
- & Juha P. Väyrynen
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Article
| Open Access
Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
- Masatoshi Kitakaze
- , Mamoru Uemura
- & Hideshi Ishii
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Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome
- Quan Zhou
- , Yuxi Ou
- & Haowen Jiang
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Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment
- Zhimin Du
- , Hui Zhang
- & Jinheng Wang
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Correspondence |
Comment on ‘Use the term “infiltrative” instead of “replacement” when defining histopathological growth pattern in patients with liver cancer’ by Kong B et al.
- Peter Vermeulen
- , Emily Latacz
- & Luc Dirix
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Comment
| Open Access
Thinking inside the box: intracellular roles for complement system proteins come into focus
- Rebecca M. O’Brien
- , Niamh Lynam-Lennon
- & Monica M. Olcina
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Single-cell sequencing of PIT1-positive pituitary adenoma highlights the pro-tumour microenvironment mediated by IFN-γ-induced tumour-associated fibroblasts remodelling
- Liang Lyu
- , Yong Jiang
- & Senlin Yin
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Correspondence |
Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”
- Pavel Nesmiyanov
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Article
| Open Access
3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma
- Yago Juste-Lanas
- , Natalia Díaz-Valdivia
- & Jordi Alcaraz
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Perspective |
Cell proliferation, drug distribution and therapeutic effects in relation to the vascular system of solid tumours
- Ian F. Tannock
- & G. Gordon Steel
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Review Article |
Reprogramming immune cells activity by furin-like enzymes as emerging strategy for enhanced immunotherapy in cancer
- Alexia François
- , Jean Descarpentrie
- & Abdel-Majid Khatib
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Article
| Open Access
Impact of adjuvant chemotherapy and radiotherapy on tumour-infiltrating lymphocytes and PD-L1 expression in metastatic breast cancer
- Shu Yazaki
- , Roberto Salgado
- & Kan Yonemori
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Review Article
| Open Access
“Stromal cells in prostate cancer pathobiology: friends or foes?”
- Filippo Pederzoli
- , Massimiliano Raffo
- & Massimo Loda
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Review Article
| Open Access
Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect
- Senbo Liu
- , Yan Zhang
- & Chengzeng Wang
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IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma
- Mengxiang Zhao
- , Yijia He
- & Liang Ding
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Review Article |
Evolving roles of CD38 metabolism in solid tumour microenvironment
- Long Gao
- , Xiaohong Du
- & F. Xiao-Feng Qin
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Perspective
| Open Access
How the histological structure of some lung cancers shaped almost 70 years of radiobiology
- Katja R. Worth
- , Ioanna Papandreou
- & Ester M. Hammond
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Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer
- Kuo-Hsing Chen
- , Chia-Lang Hsu
- & Kun-Huei Yeh
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Article
| Open Access
Integrative immune transcriptomic classification improves patient selection for precision immunotherapy in advanced gastro-oesophageal adenocarcinoma
- Manuel Cabeza-Segura
- , Valentina Gambardella
- & Tania Fleitas
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Comment |
Intratumour heterogeneity, from hypothesis to the clinic
- Naing Lin Shan
- , Adriana Kahn
- & Lajos Pusztai
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Article
| Open Access
FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
- Catherine Davidson
- , David Taggart
- & Alan Serrels
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
The tumour-associated stroma correlates with poor clinical outcomes and immunoevasive contexture in patients with upper tract urothelial carcinoma: results from a multicenter real-world study (TSU-01 Study)