Featured
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Genetics and Genomics
| Open AccessGNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi
- M J C Vader
- , M C Madigan
- & P A van der Velden
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Molecular Diagnostics
| Open AccessDiagnostic value of CA19.9, circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours
- David Sefrioui
- , France Blanchard
- & Frédéric Di Fiore
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Genetics and Genomics
| Open AccessEvidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia
- Stephanie A Schubert
- , Dina Ruano
- & Tom van Wezel
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Genetics and Genomics
| Open AccessClinical study of genomic drivers in pancreatic ductal adenocarcinoma
- Michael T Barrett
- , Ray Deiotte
- & Daniel D Von Hoff
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Genetics and Genomics
| Open AccessComprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component
- M Henar Alonso
- , Susanna Aussó
- & Victor Moreno
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Clinical Study
| Open AccessThe role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab
- Laura Demurtas
- , Marco Puzzoni
- & Mario Scartozzi
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Molecular Diagnostics
| Open AccessPrevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer
- Daniel Kazdal
- , Alexander Harms
- & Arne Warth
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Genetics and Genomics
| Open AccessA meta-analysis of CXCL12 expression for cancer prognosis
- Harsh Samarendra
- , Keaton Jones
- & Alex Gordon-Weeks
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Genetics and Genomics
| Open AccessSequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma
- Leanne de Kock
- , Barbara Rivera
- & William D Foulkes
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Molecular Diagnostics
| Open AccessMutation status among patients with sinonasal mucosal melanoma and its impact on survival
- Moran Amit
- , Samantha Tam
- & Ehab Y Hanna
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Genetics and Genomics
| Open AccessThe spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities
- Jonathan Noujaim
- , Robin L Jones
- & Khin Thway
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Review
| Open AccessTissue-based next generation sequencing: application in a universal healthcare system
- Seán O Hynes
- , Brendan Pang
- & Manuel Salto-Tellez
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Genetics and Genomics
| Open AccessEnrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci
- Siddhartha P Kar
- , Emily Adler
- & Kate Lawrenson
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Clinical Study
| Open AccessEGFR mutation detection in circulating cell-free DNA of lung adenocarcinoma patients: analysis of LUX-Lung 3 and 6
- Yi-Long Wu
- , Lecia V Sequist
- & James Chih-Hsin Yang
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Clinical Study
| Open AccessChildhood neuroendocrine tumours: a descriptive study revealing clues for genetic predisposition
- I J Diets
- , I D Nagtegaal
- & M C J Jongmans
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Clinical Study
| Open AccessNon-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment
- J L Kuiper
- , S M S Hashemi
- & E F Smit
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Epidemiology
| Open AccessHeight, height-related SNPs, and risk of non-melanoma skin cancer
- Xin Li
- , Liming Liang
- & Jiali Han
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Short Communication
| Open AccessAn investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer
- Bin Zhu
- , Anwesha Mukherjee
- & Nilanjan Chatterjee
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Letter to the Editor
| Open AccessComment on ‘The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study’
- Bernard Friedenson
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Mini Review
| Open AccessGenetic progression of Barrett’s oesophagus to oesophageal adenocarcinoma
- Eleanor M Gregson
- , Jan Bornschein
- & Rebecca C Fitzgerald
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Molecular Diagnostics
| Open AccessA UK feasibility and validation study of the VE1 monoclonal antibody immunohistochemistry stain for BRAF-V600E mutations in metastatic melanoma
- Michelle Chin I Lo
- , Anna Paterson
- & Laszlo Igali
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Mini Review
| Open AccessMolecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies
- Shivshankari Rajkumar
- & Ian R Watson
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Genetics and Genomics
| Open AccessMendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer
- David Jarvis
- , Jonathan S Mitchell
- & Richard S Houlston
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Molecular Diagnostics
| Open AccessMutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection
- Wulfran Cacheux
- , Etienne Rouleau
- & Astrid Lièvre
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Genetics and Genomics
| Open AccessMED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas
- Kati Kämpjärvi
- , Netta Mäkinen
- & Pia Vahteristo
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Molecular Diagnostics
| Open AccessExpression of two WFDC1/ps20 isoforms in prostate stromal cells induces paracrine apoptosis through regulation of PTGS2/COX-2
- Oliver J Hickman
- , Richard A Smith
- & Christine Galustian
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Genetics and Genomics
| Open AccessCommon genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity
- Mahbubl Ahmed
- , Leila Dorling
- & Catharine M L West
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Mini Review
| Open AccessThe clinical implications of gene mutations in chronic lymphocytic leukaemia
- Davide Rossi
- & Gianluca Gaidano
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Genetics and Genomics
| Open AccessThe incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study
- Javaid Iqbal
- , Andre Nussenzweig
- & Ophira Ginsburg
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Mini Review
| Open AccessInhibition of histone deacetylases in cancer therapy: lessons from leukaemia
- Elena Ceccacci
- & Saverio Minucci
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Clinical Study
| Open AccessClinical impact of mutation fraction in epidermal growth factor receptor mutation positive NSCLC patients
- Petra Martin
- , Carolyn J Shiau
- & Natasha B Leighl
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Mini Review |
PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions
- Jonathan A Ledermann
- & Fatima El-Khouly
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Molecular Diagnostics
| Open AccessMutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group
- Claudia Vollbrecht
- , Robert Werner
- & Fabian Dominik Mairinger
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Short Communication
| Open AccessNovel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer
- Alessio Amatu
- , Alessio Somaschini
- & Salvatore Siena
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Clinical Study
| Open AccessHistopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort
- Tetiana I Bogdanova
- , Liudmyla Yu Zurnadzhy
- & Alina V Brenner
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Clinical Study
| Open AccessClinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer
- Fotios Loupakis
- , Roberto Moretto
- & Emilio Bria
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Genetics and Genomics
| Open AccessOverexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma
- Chao Fan
- , Lu Chen
- & Jie Wu
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Mini Review
| Open AccessUpcoming translational challenges for uveal melanoma
- Amirouchene-Angelozzi Nabil
- , Schoumacher Marie
- & Roman-Roman Sergio
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Short Communication
| Open AccessImpact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
- David M Gershenson
- , Charlotte C Sun
- & Kwong-Kwok Wong
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Genetics and Genomics
| Open AccessOverall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis
- Feng-Che Kuan
- , Liang-Tseng Kuo
- & Kuan-Der Lee
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Genetics and Genomics
| Open AccessPolygenic susceptibility to testicular cancer: implications for personalised health care
- Kevin Litchfield
- , Jonathan S Mitchell
- & Clare Turnbull
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Molecular Diagnostics
| Open AccessPTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients
- Elizabeth A Punnoose
- , Roberta Ferraldeschi
- & Johann de Bono
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Letter to the Editor
| Open AccessBRAF-mutated metastatic colorectal cancer between past and future
- Chiara Cremolini
- , Massimo Di Maio
- & Filippo Pietrantonio
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Genetics and Genomics
| Open AccessTERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast
- Masayuki Yoshida
- , Reiko Ogawa
- & Shigeki Sekine
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Molecular Diagnostics
| Open AccessPotential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers
- Ruth Exner
- , Walter Pulverer
- & Gerda Egger
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Genetics and Genomics
| Open AccessIdentification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
- K O’Leary
- , A Shia
- & P Schmid
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Translational Therapeutics
| Open AccessPIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas
- Jonathan D Black
- , Salvatore Lopez
- & Alessandro D Santin
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Genetics and Genomics
| Open AccessWild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer
- Robert N Jorissen
- , Michael Christie
- & Oliver M Sieber