Featured
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News |
All eyes on the potato genome
Cracking of tricky genetic code may offer clues to fighting blight.
- Chloe McIvor
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Research Highlights |
RNA scaffolds boost biosynthesis
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Books & Arts |
Stem cells: The clash of hype, hope and stem cells
A revealing book investigates the politicization of regenerative medicine, finds Gilberto Corbellini.
- Gilberto Corbellini
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News & Views |
Muscle for a damaged heart
When cardiac muscle cells die during a heart attack, this can lead to heart failure and even death. It now emerges that stem cells of the 'sheet' enveloping the heart can be coaxed to form new muscle after such an event. See Letter p.640
- Vincent Christoffels
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News Q&A |
Stem-cell boss urges communication
Incoming chairman wants public to know about California stem-cell agency's work.
- Erika Check Hayden
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Letter |
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
- Sayaka Sekiya
- & Atsushi Suzuki
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News |
Stem-cell scientists grapple with clinics
In the absence of regulation, researchers weigh their options for educating patients about unproven treatments.
- Heidi Ledford
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Letter |
In vivo genome editing restores haemostasis in a mouse model of haemophilia
- Hojun Li
- , Virginia Haurigot
- & Katherine A. High
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Outlook |
Algae: The scum solution
The green slime that covers ponds is an efficient factory for turning sunlight into fuel, but growing it on an industrial scale will take ingenuity.
- Neil Savage
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Spotlight |
Spotlight on Biotech / Pharma
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News Q&A |
Vaccines warrant firm focus
Diseases such as malaria and HIV still present a major challenge to vaccine development, says Gates foundation's departing global-health chief.
- Erika Check Hayden
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News |
Nanoparticles hit tumours with one-two punch
Using scout particles to pave the way makes drug delivery more effective.
- Corie Lok
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Letter |
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- Joshua M. Baughman
- , Fabiana Perocchi
- & Vamsi K. Mootha
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News |
Hepatitis C mouse model a major milestone
Development paves the way for testing potential vaccines.
- Virginia Gewin
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News |
Stem cells patch up 'broken' heart
Cell reactivation in mouse hearts repairs muscle after heart attack.
- Marian Turner
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Research Highlights |
Gene repair tool for stem cells
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News & Views |
Mosquitoes bamboozled
Mosquitoes harbouring the malaria parasite follow pulses of carbon dioxide exhaled by their human prey to track them down. A novel set of chemicals can distract these insects by disrupting their sense of smell. See Letter p.87
- Mark Stopfer
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Research Highlights |
Bacterial chemical factories
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News & Views |
Persistence pays off
Developing AIDS vaccines has been a frustrating business. A vaccine that triggers immune responses that effectively control early infection by the simian counterpart of HIV in macaques seems promising. See Letter p.523
- R. Paul Johnson
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News |
Engineered antibodies cross blood–brain barrier
Technique could be used to design therapies for Alzheimer's and other diseases.
- Heidi Ledford
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Feature |
Forensics: The call of the crime lab
Forensic scientists can work in academia, government and the private sector, but the field is competitive.
- Virginia Gewin
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Technology Feature |
The next step for the synthetic genome
Biologists have copied an existing genetic code, but haven't yet commercialized it or written their own. What will it take for a tour de force to reach industrial force?
- Monya Baker
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News |
Reprogrammed cells trigger immune reactions in mice
Medical applications of induced pluripotent stem cells called into question.
- Erika Check Hayden
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Letter |
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
- Pengyu Huang
- , Zhiying He
- & Lijian Hui
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Inside View |
Inside View: CRP-Santé
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Research Highlights |
Patching up the heart
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Books & Arts |
Books in brief
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Research Highlights |
New ways to change fates
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Spotlight |
Spotlight on Biotech/Pharma
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Letter |
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
- Nikolai Windbichler
- , Miriam Menichelli
- & Andrea Crisanti
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News |
Grants aim to fight malnutrition
Cash boost should help bring fortified rice and cassava to market.
- Anjali Nayar
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Books & Arts |
Biotechnology: DIY biology
Bart Penders relishes an account of 'biohackers' who experiment beyond the confines of the lab.
- Bart Penders
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Feature |
California: Safe harbour
San Diego's diverse corporate science portfolio offers opportunities for open-minded scientists hoping to escape stagnation in academia.
- Karen Kaplan
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News |
Stem cells make 'retina in a dish'
Mouse cells have been coaxed into forming a retina, the most complex tissue yet engineered.
- Ewen Callaway
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News |
Antarctic microbes live life to the extreme
Chilean Antarctic survey finds dramatic variety of organisms adapted to unusual conditions.
- Patricio Segura Ortiz
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Letter |
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
- Amar Sahay
- , Kimberly N. Scobie
- & René Hen
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Technology Feature |
A living system on a chip
For years, scientists have struggled to reconstruct tissues and organs by combining cells and nanotechnology. These devices are now edging from cool concept to practical application.
- Monya Baker
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News |
Europe fails to reach deal on cloned meat
EU bodies at odds over the labelling and sale of products from clones and their descendants.
- Barbara Casassus
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Books & Arts |
Biotechnology: Making people
Today's wariness of reproductive technologies stems from myths, legends and Hollywood, finds Chris Mason.
- Chris Mason
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Research Highlights |
Slip and slide pores for sensors
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Q&A |
Turning point: Louise Glass
Microbiologist Louise Glass's new fellowship will help her pursue a longstanding interest in converting fungi to bioenergy.
- Virginia Gewin
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News & Views |
Annelid who's who
The origin of the annelids is buried in distant evolutionary time. A molecular phylogeny resolves their deep family interrelationships and provides a picture of their 'urannelid' ancestor. See Letter p.95
- Detlev Arendt
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Career Brief |
Tax credits help firms
Government programme helped biotechnology companies create and save jobs.
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News |
Genzyme deal set to alter biotech landscape
Maintaining innovative culture will be a key challenge for new owners of industry stalwart.
- Heidi Ledford
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