Editorial |
Featured
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News & Views |
Overcoming delivery barriers with LNPs
Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.
- Satish G. Jadhav
- & Steven F. Dowdy
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Article |
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
It is now shown that tumour-associated macrophages recruited early during tumour evolution stimulate stromal fibroblasts to express collagen crosslinking enzymes and that the stromal expression, particularly of lysyl hydroxylase 2, can predict survival in a patient cohort.
- Ori Maller
- , Allison P. Drain
- & Valerie M. Weaver
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Article |
Cofactor-free oxidase-mimetic nanomaterials from self-assembled histidine-rich peptides
Self-assembling, histidine-rich peptides with similar catalytic functions as those of haem-dependent peroxidases are reported. These findings may have implications for the design of cofactor-free catalytic nanomaterials.
- Qing Liu
- , Kaiwei Wan
- & Baoquan Ding
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Comment |
Towards data-driven next-generation transmission electron microscopy
Electron microscopy touches on nearly every aspect of modern life, underpinning materials development for quantum computing, energy and medicine. We discuss the open, highly integrated and data-driven microscopy architecture needed to realize transformative discoveries in the coming decade.
- Steven R. Spurgeon
- , Colin Ophus
- & Mitra L. Taheri
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Why it Matters |
Sipping a bit of science
Laura Benzonana and Nikos Sgantzis reflect on their experience as organizers for Pint of Science in Greece.
- Laura Benzonana
- & Nikolaos Sgantzis
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News & Views |
Dynamic mechanics
The discovery of a hypersonic bandgap in spider silk could drive the design of bio-inspired and biocompatible dynamic materials.
- Isabelle Su
- & Markus J. Buehler
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News & Views |
A candidate magnetoreceptor
A protein complex found to align with the direction of a magnetic field could be a key piece in the puzzle of how animals detect magnetic fields.
- Kenneth J. Lohmann
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Article |
A magnetic protein biocompass
A polymeric protein complex consisting of a newly identified magnetoreceptor protein and known magnetoreception-related photoreceptor cryptochromes exhibits spontaneous alignment in magnetic fields.
- Siying Qin
- , Hang Yin
- & Can Xie
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News & Views |
Enzymatically crosslinked scaffolds
Microgel particle precursors bearing peptide substrates for human enzymes crosslink in wound sites to produce bioactive scaffolds in situ that rapidly recruit cells and promote dermal healing.
- David W. Grainger
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News & Views |
Sensing rigidity
Cells use differences in the binding rates between the extracellular matrix and integrin adhesion receptors to sense matrix rigidity.
- José R. García
- & Andrés J. García
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News & Views |
Lighting the way
Advances in photochemistry have profoundly impacted the way in which biology is studied. Now, a photoactivated enzymatic patterning method that offers spatiotemporal control over the presentation of bioactive proteins to direct cells in three-dimensional culture significantly expands the available chemical toolbox.
- Daniel L. Alge
- & Kristi S. Anseth
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News & Views |
Sharing the force
Cells can sense their environment by applying and responding to mechanical forces, yet how these forces are transmitted through the cell's cytoskeleton is largely unknown. Now, a combination of experiments and computer simulations shows how forces applied to the cell cortex are synergistically shared by motor proteins and crosslinkers.
- Andreas R. Bausch
- & Ulrich S. Schwarz
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News & Views |
Know your molecules
A new plasmonic sensing platform that not only allows the detection of ultrasmall quantities of biomolecules, but is also sensitive to their identity and conformational state, represents a significant advance in the study of biomolecular interactions.
- Na Liu
- & Annemarie Pucci
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News & Views |
To knot or not to knot?
A knot-containing protein is found to fold reversibly at biologically relevant timescales despite not having naturally evolved for this ability.
- Eugene Shakhnovich
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Article |
DNA translocation through an array of kinked nanopores
Synthetic solid-state nanopores are of interest at present for their use as single-molecule sensors for characterization and detection of biomolecules. By using self-assembly evaporation and atomic-layer deposition, kinked silica nanopores are shown to exhibit reduction in DNA-translocation velocity and selectivity.
- Zhu Chen
- , Yingbing Jiang
- & C. Jeffrey Brinker
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