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GENE EDITING

Overcoming delivery barriers with LNPs

Nature Materials volume 20, pages 575–577 (2021)Cite this article

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Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.

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Fig. 1: iPhos lipid design directs LNP tissue targeting.

adapted with permission from ref. 6, Springer Nature Ltd.

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Authors and Affiliations

  1. Department of Cellular & Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, CA, USA

    Satish G. Jadhav & Steven F. Dowdy

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  1. Satish G. Jadhav
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  2. Steven F. Dowdy
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Correspondence to Steven F. Dowdy.

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Competing interests

S.F.D. is a member of the scientific advisory board of Generation Bio, a gene therapy biotechnology company.

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Jadhav, S.G., Dowdy, S.F. Overcoming delivery barriers with LNPs. Nat. Mater. 20, 575–577 (2021). https://doi.org/10.1038/s41563-021-00988-3

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