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Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials
A modular approach of photoreversible patterning of macromolecules with high spatiotemporal resolution within hydrogels is employed to generate biomaterials with controllable cell activity through site-specific immobilization of proteins.
- Jared A. Shadish
- , Gabrielle M. Benuska
- & Cole A. DeForest
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News & Views |
A candidate magnetoreceptor
A protein complex found to align with the direction of a magnetic field could be a key piece in the puzzle of how animals detect magnetic fields.
- Kenneth J. Lohmann
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News & Views |
Sensing rigidity
Cells use differences in the binding rates between the extracellular matrix and integrin adhesion receptors to sense matrix rigidity.
- José R. García
- & Andrés J. García
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News & Views |
Lighting the way
Advances in photochemistry have profoundly impacted the way in which biology is studied. Now, a photoactivated enzymatic patterning method that offers spatiotemporal control over the presentation of bioactive proteins to direct cells in three-dimensional culture significantly expands the available chemical toolbox.
- Daniel L. Alge
- & Kristi S. Anseth
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News & Views |
Sharing the force
Cells can sense their environment by applying and responding to mechanical forces, yet how these forces are transmitted through the cell's cytoskeleton is largely unknown. Now, a combination of experiments and computer simulations shows how forces applied to the cell cortex are synergistically shared by motor proteins and crosslinkers.
- Andreas R. Bausch
- & Ulrich S. Schwarz
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News & Views |
Functional droplet networks
Tissue-mimicking printed networks of droplets separated by lipid bilayers that can be functionalized with membrane proteins are able to spontaneously fold and transmit electrical currents along predefined paths.
- Naside Gozde Durmus
- , Savas Tasoglu
- & Utkan Demirci
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