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News & Views |
Moving hydrogels to the fourth dimension
Materials that permit spatiotemporal control of biomolecule presentation have long been a challenge in the field. A method has now been developed to reversibly pattern cell-laden hydrogels with site-specifically immobilized proteins using sortase-mediated transpeptidation without compromising bioactivity.
- Jonathan H. Galarraga
- & Jason A. Burdick
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Article |
Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials
A modular approach of photoreversible patterning of macromolecules with high spatiotemporal resolution within hydrogels is employed to generate biomaterials with controllable cell activity through site-specific immobilization of proteins.
- Jared A. Shadish
- , Gabrielle M. Benuska
- & Cole A. DeForest
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