PRPS1 assembles for allosteric activation

PRPS1 assembles for allosteric activation

A series of cryo-EM structures of PRPS1 reveal formation of D3 symmetric hexamers, which assemble into filaments, stabilising allosteric sites within the enzyme and promoting its activation.

  • Kelli L. Hvorecny
  • Kenzee Hargett
  • Justin M. Kollman


  • The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch." Their research identified transient receptor potential (TRP) and PIEZO ion channels as the proteins that sense these ubiquitous stimuli. To celebrate the award Nature Portfolio presents a Collection of articles on the topic.

  • Genome editing has great potential to change how we model, understand, and treat diseases. The Somatic Cell Genome Editing Consortium brings together investigators from 33 institutions to accelerate the development of editing tools, animal models, delivery approaches and therapeutic applications of genome editing.

Nature Structural & Molecular Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

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  • Here, using cryo-EM and biochemical methods, the authors demonstrate that second messenger (p)ppGpp regulates the bacterial RNA polymerase by binding to a site that is functionally relevant during transcriptional elongation but not initiation. Moreover, they demonstrate that binding to that site bears functional implications for nucleotide excision DNA repair and genome stability.

    • Jacob W. Weaver
    • Sergey Proshkin
    • Evgeny Nudler
    Article Open Access
  • Gabapentinoid drugs are widely used for pain, epilepsy and mental disorders. Chen et al. report the structure of a gabapentin-bound brain and heart calcium channel, revealing the gabapentin binding site and isoform-selective binding determinants.

    • Zhou Chen
    • Abhisek Mondal
    • Daniel L. Minor Jr
    Brief Communication
  • Using atomic force microscopy, Pan et al. show that cyclic nucleotide-gated ion channel SthK, which can be differentially activated by cAMP and cGMP, binds both cyclic nucleotides but only cAMP can access a deep-bound state that could be essential for cAMP-dependent channel activation.

    • Yangang Pan
    • Emmi Pohjolainen
    • Simon Scheuring
  • Tsirigotaki et al. unveil how adipokine Leptin induces trimerization of the Leptin receptor to form a cytokine-receptor assembly critical to body weight regulation, immunity, fertility and cancer.

    • Alexandra Tsirigotaki
    • Ann Dansercoer
    • Kenneth Verstraete