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Meiotic recombination

A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

Nature Structural & Molecular Biology volume 31, pages 584–585 (2024)Cite this article

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Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.

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Fig. 1: Protein components of the central element of the synaptonemal complex.

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Acknowledgements

S.A.C. is supported by a US National Science Foundation Graduate Research Fellowship (1746891). R.C.M. is supported by US National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) Award R35GM133747. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Department of Biology, Johns Hopkins University, Baltimore, MD, USA

    Sara A. Carioscia & Rajiv C. McCoy

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  1. Sara A. Carioscia
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  2. Rajiv C. McCoy
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Correspondence to Rajiv C. McCoy.

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The authors declare no competing interests.

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Carioscia, S.A., McCoy, R.C. A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss. Nat Struct Mol Biol 31, 584–585 (2024). https://doi.org/10.1038/s41594-024-01269-8

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