Kalienkova et al. report high-resolution structures of an FMRFamide-gated sodium channel in several functional states. This disentangles the molecular basis by which different invertebrate receptors recognize similar neuropeptides and paves the way for studies of channel gating and ion conduction among the degenerin/epithelial sodium channel superfamily.

See Kalienkova et al.

A study by Isaac et al. presents mtFiber-seq, a method that measures individual mitochondrial genome packaging at nucleotide resolution, providing insight into the architecture of mitochondrial DNA packaging.

See Isaac et al.

In this issue, we feature seven studies that progress our understanding of writers and readers of ubiquitylation, in addition to a Historical Perspective and several Comment pieces reflecting on the ever-expanding roles of this critical modification.

See Editorial

To celebrate Nature Structural & Molecular Biology’s 30th anniversary, our cover features original artwork that was submitted by our reader Pedro Rebelo-Guiomar for our cover competition.

See Rebelo-Guiomar and Editorial