The human cytoskeleton consists of three major classes of filaments: microfilaments, microtubules and intermediate filaments. Here, we summarize recent progress in deciphering the structure and function of intermediate filaments and their implications for human disease.
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Acknowledgements
This work was supported by the United States National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases under award number R01 AR079428 (to C.G.B.).
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C.G.B. and M.H. declare patents filed for therapeutic targeting of IFs.
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Lomakin, I.B., Ho, M. & Bunick, C.G. Unveiling the secrets of vimentin filament architecture relevant to human disease. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01301-x
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DOI: https://doi.org/10.1038/s41594-024-01301-x
