Targeted biologics delivery requires programming multicomponent protein nanomaterials to enable selective targeting and response to environment changes in a single unified framework. A novel protein nanoparticle platform has been designed to modulate cell-surface target specificity, cargo packaging, and pH-dependent release of encapsulated cargo, providing exciting possibilities in biologics delivery.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Boyken, S. E. et al. De novo design of tunable, pH-driven conformational changes. Science 364, 658–664 (2019). This paper reports the engineering of proteins to respond to changes in pH.
Divine, R. et al. Designed proteins assemble antibodies into modular nanocages. Science 372, eabd9994 (2021). This paper reports the design of antibody-incorporating nanoparticles.
Hsia, Y. et al. Design of multi-scale protein complexes by hierarchical building block fusion. Nat. Commun. 12, 2294 (2021). This paper reports a computational helical fusion method.
Sheffler, W. et al. Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock. PLOS Comput. Biol. 19, e1010680 (2023). This paper reports a computational rigid-body docking method.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Yang, E. C. et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01288-5 (2024).
Rights and permissions
About this article
Cite this article
Custom protein nanoparticles for targeted drug delivery. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01289-4
Published:
DOI: https://doi.org/10.1038/s41594-024-01289-4