Browse our September issue

Latest Research

  • Article |

    Cryo-EM data and functional assays reveal how the actin-cross-linking protein filamin A interacts with F-actin, rationalizing human disease mutations in molecular detail.

    • Daniel V. Iwamoto
    • , Andrew Huehn
    • , Bertrand Simon
    • , Clotilde Huet-Calderwood
    • , Massimiliano Baldassarre
    • , Charles V. Sindelar
    •  & David A. Calderwood
  • Article |

    Structural, biochemical, and modeling studies reveal how the non-canonical RNA Pol II subunit Gdown1 precludes general transcription factor interactions with Pol II(G) to repress transcriptional activity in the absence of Mediator.

    • Miki Jishage
    • , Xiaodi Yu
    • , Yi Shi
    • , Sai J. Ganesan
    • , Wei-Yi Chen
    • , Andrej Sali
    • , Brian T. Chait
    • , Francisco J. Asturias
    •  & Robert G. Roeder
  • Article |

    Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress.

    • Mingfeng Zhang
    • , Dali Wang
    • , Yunlu Kang
    • , Jing-Xiang Wu
    • , Fuqiang Yao
    • , Chengfang Pan
    • , Zhiqiang Yan
    • , Chen Song
    •  & Lei Chen
  • Review Article |

    Cramer and colleagues review and discuss how the structural elucidation of transcription factors and functional complexes of human mitochondrial RNA polymerase have informed emerging understanding of the mechanism of mitochondrial gene transcription.

    • Hauke S. Hillen
    • , Dmitry Temiakov
    •  & Patrick Cramer
  • Article |

    Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.

    • Kata Sarlós
    • , Andreas S. Biebricher
    • , Anna H. Bizard
    • , Julia A. M. Bakx
    • , Anna G. Ferreté-Bonastre
    • , Mauro Modesti
    • , Manikandan Paramasivam
    • , Qi Yao
    • , Erwin J. G. Peterman
    • , Gijs J. L. Wuite
    •  & Ian D. Hickson

News & Comment

Series

NSMB 25

We mark the 25th year of NSMB with a special Series of commissioned Reviews and Comments that celebrate exciting research uncovering the fundamental principles behind biological processes.